638 research outputs found
Barriers to using a polypill in the secondary prevention of stroke: A qualitative interview based study
Simulation Study of Sulfonate Cluster Swelling in Ionomers
We have performed simulations to study how increasing humidity affects the
structure of Nafion-like ionomers under conditions of low sulfonate
concentration and low humidity. At the onset of membrane hydration, the
clusters split into smaller parts. These subsequently swell, but then maintain
constant the number of sulfonates per cluster. We find that the distribution of
water in low-sulfonate membranes depends strongly on the sulfonate
concentration. For a relatively low sulfonate concentration, nearly all the
side-chain terminal groups are within cluster formations, and the average water
loading per cluster matches the water content of membrane. However, for a
relatively higher sulfonate concentration the water-to-sulfonate ratio becomes
non-uniform. The clusters become wetter, while the inter-cluster bridges become
drier. We note the formation of unusual shells of water-rich material that
surround the sulfonate clusters.Comment: 24 pages, 15 figure
The effects of FES cycling combined with virtual reality racing biofeedback on voluntary function after incomplete SCI: a pilot study
BACKGROUND: Functional Electrical Stimulation (FES) cycling can benefit health and may lead to neuroplastic changes following incomplete spinal cord injury (SCI). Our theory is that greater neurological recovery occurs when electrical stimulation of peripheral nerves is combined with voluntary effort. In this pilot study, we investigated the effects of a one-month training programme using a novel device, the iCycle, in which voluntary effort is encouraged by virtual reality biofeedback during FES cycling. METHODS: Eleven participants (C1-T12) with incomplete SCI (5 sub-acute; 6 chronic) were recruited and completed 12-sessions of iCycle training. Function was assessed before and after training using the bilateral International Standards for Neurological Classification of SCI (ISNC-SCI) motor score, Oxford power grading, Modified Ashworth Score, Spinal Cord Independence Measure, the Walking Index for Spinal Cord Injury and 10 m-walk test. Power output (PO) was measured during all training sessions. RESULTS: Two of the 6 participants with chronic injuries, and 4 of the 5 participants with sub-acute injuries, showed improvements in ISNC-SCI motor score > 8 points. Median (IQR) improvements were 3.5 (6.8) points for participants with a chronic SCI, and 8.0 (6.0) points for those with sub-acute SCI. Improvements were unrelated to other measured variables (age, time since injury, baseline ISNC-SCI motor score, baseline voluntary PO, time spent training and stimulation amplitude; p > 0.05 for all variables). Five out of 11 participants showed moderate improvements in voluntary cycling PO, which did not correlate with changes in ISNC-SCI motor score. Improvement in PO during cycling was positively correlated with baseline voluntary PO (R2 = 0.50; p 0.05). The iCycle was not suitable for participants who were too weak to generate a detectable voluntary torque or whose effort resulted in a negative torque. CONCLUSIONS: Improved ISNC-SCI motor scores in chronic participants may be attributable to the iCycle training. In sub-acute participants, early spontaneous recovery and changes due to iCycle training could not be distinguished. The iCycle is an innovative progression from existing FES cycling systems, and positive results should be verified in an adequately powered controlled trial. TRIAL REGISTRATION: ClinicalTrials.gov, NCT03834324. Registered 06 February 2019 - Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT03834324. Protocol V03, dated 06.08.2015
Optimised configuration of sensors for fault tolerant control of an electro-magnetic suspension system
For any given system the number and location of sensors can affect the closed-loop performance as well as the reliability of the system. Hence, one problem in control system design is the selection of the sensors in some optimum sense that considers both the system performance and reliability. Although some methods have been proposed that deal with some of the aforementioned aspects, in this work, a design framework dealing with both control and reliability aspects is presented. The proposed framework is able to identify the best sensor set for which optimum performance is achieved even under single or multiple sensor failures with minimum sensor redundancy. The proposed systematic framework combines linear quadratic Gaussian control, fault tolerant control and multiobjective optimisation. The efficacy of the proposed framework is shown via appropriate simulations on an electro-magnetic suspension system
Sustaining municipal parks in an era of neoliberal austerity: The contested commercialisation of Gunnersbury Park
This paper analyses a potentially path shaping moment for the UK’s public parks by analysing a pivotal case study of park neoliberalisation. Like many municipal parks, Gunnersbury Park in West London is experiencing the effects of local government budget cuts. Governance, policy and physical changes have been introduced to reduce dependence on public funding and the result is a more commercially oriented park. This case is used to better understand how the period of neoliberal austerity 2010-2020 reshaped municipal parks. The paper highlights concerns over the transparency and accountability of the social enterprise that now manages Gunnersbury Park. It also shows how neoliberalisation and commercialisation are manifested in the park landscape: free events are replaced with ticketed ones, spaces for sport are transformed into bookable facilities, cafes are taken over by corporate chains and playgrounds are supplemented with paid entry alternatives. One of the main consequences is the financial and symbolic exclusion of those unable or unwilling to pay. The paper explores who has contested the recent changes, and why. Opponents are dismissed as idealistic NIMBYs but, by refusing to accept the post-political inevitability of park neoliberalisation, they are helping to ensure Gunnersbury Park’s remains a public and open space. The case is contextualised by situating it within a review of new park governance arrangements across London, and by comparing neoliberalisation processes here with those affecting New York parks. Ultimately, the research highlights the pitfalls of shifting away from the public funding and public management of municipal parks.
Multiple Incommensurate Magnetic States in the Kagome Antiferromagnet Na2Mn3Cl8
The kagome lattice can host exotic magnetic phases arising from frustrated
and competing magnetic interactions. However, relatively few insulating kagome
materials exhibit incommensurate magnetic ordering. Here, we present a study of
the magnetic structures and interactions of antiferromagnetic
NaMnCl with an undistorted Mn kagome network. Using
neutron-diffraction and bulk magnetic measurements, we show that
NaMnCl hosts two different incommensurate magnetic states, which
develop at K and K. Magnetic Rietveld refinements
indicate magnetic propagation vectors of the form , and our neutron-diffraction data can be well
described by cycloidal magnetic structures. By optimizing exchange parameters
against magnetic diffuse-scattering data, we show that the spin Hamiltonian
contains ferromagnetic nearest-neighbor and antiferromagnetic third-neighbor
Heisenberg interactions, with a significant contribution from long-ranged
dipolar coupling. This experimentally-determined interaction model is compared
with density-functional-theory simulations. Using classical Monte Carlo
simulations, we show that these competing interactions explain the experimental
observation of multiple incommensurate magnetic phases and may stabilize
multi- states. Our results expand the known range of magnetic
behavior on the kagome lattice.Comment: 13 pages, 8 figure
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