Therapeutic potentials of curcumin in the treatment of glioblstoma

Glioblastoma multiforme (GBM), a greatly aggressive malignancy of the brain, is correlated with a poor prognosis and low rate of survival. Up to now, chemotherapy and radiation therapy after surgical approaches have been the treatments increasing the survival rates. The low efficacy of mentioned therapies as well as their side-effects has forced researchers to explore an appropriate alternative or complementary treatment for glioblastoma. In experimental models, it has been shown that curcumin has therapeutic potentials to fight against GBM. Given that curcumin has pharmacological effects against cancer stem cells, as major causes of resistance to therapy in glioblastoma cells. Moreover, it has been showed that curcumin exerts its therapeutic effects on GBM cells via affecting on apoptosis, oxidant system, and inflammatory pathways. Curcumin would possess a synergistic impact with chemotherapeutic agents. Herein, we summarized the current findings on curcumin as therapeutic agent in the treatment of GBM. © 2020 Elsevier Masson SA

Performance, kinetic, and biodegradation pathway evaluation of anaerobic fixed film fixed bed reactor in removing phthalic acid esters from wastewater

Emerging and hazardous environmental pollutants like phthalic acid esters (PAEs) are one of the recent concerns worldwide. PAEs are considered to have diverse endocrine disrupting effects on human health. Industrial wastewater has been reported as an important environment with high concentrations of PAEs. In the present study, four short-chain PAEs including diallyl phthalate (DAP), diethyl phthalate (DEP), dimethyl phthalate (DMP), and phthalic acid (PA) were selected as a substrate for anaerobic fixed film fixed bed reactor (AnFFFBR). The process performances of AnFFFBR, and also its kinetic behavior, were evaluated to find the best eco-friendly phthalate from the biodegradability point of view. According to the results and kinetic coefficients, removing and mineralizing of DMP occurred at a higher rate than other phthalates. In optimum conditions 92.5, 84.41, and 80.39% of DMP, COD, and TOC were removed. DAP was found as the most bio-refractory phthalate. The second-order (Grau) model was selected as the best model for describing phthalates removal

Protecting and comparing entanglement, quantum discord and quantum coherence between two moving qubits inside leaky cavities

In this study, we consider a composed system consisting of two identical non-interacting subsystems. Each sub-system is made of a moving qubit into a leaky cavity. The study of the dynamic of the composed system revealed that compared with the stationary qubits, entanglement, quantum discord and coherence between two moving qubits remained close to their initial values as time went by. In particular, we show that the entanglement, quantum discord and the initial coherence between the two qubits could be strongly protected from decay by increasing the velocity of the qubits. Furthermore, based on such results, we have drawn a comparison between the three quantum resources (entanglement, quantum discord and coherence), demonstrating that the coherence of a bipartite system could be more robust than the two other quantum resources

An Investigation into Separation of Impurity from Saffron Stigma Using an Electrostatic Separator

In the present study, a laboratory electrostatic separator was constructed and its separation potential of white saffron impurities from stigma was investigated. The device was comprised of a nylon ribbon which moves in contact with a woolen brush and was charged by the triboelectric effect. The charged ribbon, then, moved over the material pan. Since the electrostatic behavior vary from various materials, their attraction to the ribbon differ. The separation tests were conducted at three levels of ribbon position (with 1.5, 2.5 and 3.5 cm from the material pan), three drum speeds (50, 60 and 70 rpm) and three working times (120, 18 and 240 seconds). The results showed that material absorption increased as working time increased and the ribbon distance decreased. Meanwhile, rising the speed from 50 to 60 rpm improved material absorption while, more increasing from 60 to 70 rpm reduced the absorption. A maximum impurity separation of 97% was observed with ribbon distance of 1.5 cm, ribbon speed of 60 rpm and working for 240 seconds. The minimum stigma losses were found to be about 2% when the ribbon distance and speed were 3.5 cm and 70 rpm, respectively, and the separator worked for 120 seconds

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would like to thank the reviewers for their comments to improve the quality of this publication