253 research outputs found

    Chameleon-like elastomers with molecularly encoded strain-adaptive stiffening and coloration

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    Active camouflage is widely recognized as a soft-tissue feature, and yet the ability to integrate adaptive coloration and tissuelike mechanical properties into synthetic materials remains elusive. We provide a solution to this problem by uniting these functions in moldable elastomers through the self-assembly of linear-bottlebrush-linear triblock copolymers. Microphase separation of the architecturally distinct blocks results in physically cross-linked networks that display vibrant color, extreme softness, and intense strain stiffening on par with that of skin tissue. Each of these functional properties is regulated by the structure of one macromolecule, without the need for chemical cross-linking or additives. These materials remain stable under conditions characteristic of internal bodily environments and under ambient conditions, neither swelling in bodily fluids nor drying when exposed to air

    ΠœΠ•Π–Π”Π˜Π‘Π¦Π˜ΠŸΠ›Π˜ΠΠΠ ΠΠ«Π™ ΠŸΠ•Π Π‘ΠžΠΠΠ›Π˜Π—Π˜Π ΠžΠ’ΠΠΠΠ«Π™ ΠŸΠžΠ”Π₯ΠžΠ” И Π’Π•Π₯ΠΠžΠ›ΠžΠ“Π˜Π˜ Π˜Π—Π£Π§Π•ΠΠ˜Π― Π“ΠžΠ›ΠžΠ’ΠΠžΠ“Πž ΠœΠžΠ—Π“Π ПРИ Π’Π˜Π§Π˜ΠΠ€Π•ΠšΠ¦Π˜Π˜

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    There was made an attempt to link interdisciplinary research methodically, from clinical diagnostic techniques, modern instrumental, laboratory and basic research to their implementation in practice. The experience of several partner groups studying the brainΒ in HIV infection was analyzed and summarized. It was based on an interdisciplinary approach, the goals and authorities of infectious disease specialists,Β  psychiatrists, neurologists, radiologists, laboratory doctors, clinical examination algorithm, the role ofΒ history and interview, express-diagnostic of cognitive functions, specialized psychiatric, neurologicalΒ  diagnosis, conclusion of clinical psychologists, indications for radiology methods. The choice and analysis of radiological and instrumental methods, the volumeΒ and structure of laboratory methods of central nervous system study were justified. The role of molecular genetic studies of HIV inΒ blood and cerebrospinal fluid, the identification of drug-resistant forms of the virus was determined when choosing the therapy.Π‘Π΄Π΅Π»Π°Π½Π° ΠΏΠΎΠΏΡ‹Ρ‚ΠΊΠ° мСтодичСски ΡΠ²ΡΠ·Π°Ρ‚ΡŒ мСТдисциплинарныС исслСдования, начиная с клиничСских диагностичСских ΠΏΡ€ΠΈΠ΅ΠΌΠΎΠ², соврСмСнных ΠΈΠ½ΡΡ‚Ρ€ΡƒΠΌΠ΅Π½Ρ‚Π°Π»ΡŒΠ½Ρ‹Ρ…, Π»Π°Π±ΠΎΡ€Π°Ρ‚ΠΎΡ€Π½Ρ‹Ρ… ΠΈ Ρ„ΡƒΠ½Π΄Π°ΠΌΠ΅Π½Ρ‚Π°Π»ΡŒΠ½Ρ‹Ρ… исслСдований Π΄ΠΎ ΠΈΡ… Ρ€Π΅Π°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ Π² ΠΏΡ€Π°ΠΊΡ‚ΠΈΠΊΠ΅. ΠŸΡ€ΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡ€ΠΎΠ²Π°Π½Β ΠΈ ΠΎΠ±ΠΎΠ±Ρ‰Π΅Π½ ΠΎΠΏΡ‹Ρ‚ Π½Π΅ΡΠΊΠΎΠ»ΡŒΠΊΠΈΡ… партнСрских ΠΊΠΎΠ»Π»Π΅ΠΊΡ‚ΠΈΠ²ΠΎΠ² ΠΏΠΎ ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠ»ΠΎΠ³ΠΈΠΈ изучСния Π³ΠΎΠ»ΠΎΠ²Π½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π° ΠΏΡ€ΠΈ Π’Π˜Π§-ΠΈΠ½Ρ„Π΅ΠΊΡ†ΠΈΠΈ. Π’ основу лСгли мСТдисциплинарный ΠΏΠΎΠ΄Ρ…ΠΎΠ΄, Π·Π°Π΄Π°Ρ‡ΠΈ ΠΈ полномочия инфСкционистов, Π½Π°Ρ€ΠΊΠΎΠ»ΠΎΠ³ΠΎΠ²-психиатров, Π½Π΅Π²Ρ€ΠΎΠ»ΠΎΠ³ΠΎΠ², Ρ€Π°Π΄ΠΈΠΎΠ»ΠΎΠ³ΠΎΠ², Π²Ρ€Π°Ρ‡Π΅ΠΉ Π»Π°Π±ΠΎΡ€Π°Ρ‚ΠΎΡ€Π½ΠΎΠΉ слуТбы, Π°Π»Π³ΠΎΡ€ΠΈΡ‚ΠΌ клиничСского обслСдования, Ρ€ΠΎΠ»ΡŒ Π°Π½Π°ΠΌΠ½Π΅Π·Π° ΠΈ опроса, экспрСсс-диагностики ΠΊΠΎΠ³Π½ΠΈΡ‚ΠΈΠ²Π½Ρ‹Ρ…Β Ρ„ΡƒΠ½ΠΊΡ†ΠΈΠΉ, спСциализированный Π΄ΠΈΠ°Π³Π½ΠΎΠ· психиатричСский, нСврологичСский, Π·Π°ΠΊΠ»ΡŽΡ‡Π΅Π½ΠΈΠ΅ клиничСских психологов, показания для радиологичСских исслСдований. ΠžΠ±ΠΎΡΠ½ΠΎΠ²Π°Π½Ρ‹ Π²Ρ‹Π±ΠΎΡ€ ΠΈ Π°Π½Π°Π»ΠΈΠ· радиологичСских ΠΈ ΠΈΠ½ΡΡ‚Ρ€ΡƒΠΌΠ΅Π½Ρ‚Π°Π»ΡŒΠ½Ρ‹Ρ… ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠ² ΠΎΡ†Π΅Π½ΠΊΠΈ ЦНБ, объСм и структура Π»Π°Π±ΠΎΡ€Π°Ρ‚ΠΎΡ€Π½Ρ‹Ρ… ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠ² для ΠΎΡ†Π΅Π½ΠΊΠΈ процСссов Π² ЦНБ. ΠžΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½Π° Ρ€ΠΎΠ»ΡŒ молСкулярно-гСнСтичСских исслСдований Π’Π˜Π§Β Π² ΠΊΡ€ΠΎΠ²ΠΈ ΠΈ спинномозговой Тидкости, выявлСния фармакорСзистСнтных Ρ„ΠΎΡ€ΠΌ вируса, ΡƒΡ‡Π΅Ρ‚ ΠΏΡ€ΠΈ Π²Ρ‹Π±ΠΎΡ€Π΅ Ρ‚Π΅Ρ€Π°ΠΏΠΈΠΈ
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