Análise multivariada do efeito de diferentes densidades de alojamento sobre lesões podais em frangos de corte.

Este trabalho objetivou avaliar a utilização de estatísticas multivariadas para análise de um conjunto de dados com diferentes densidades de alojamento em frangos de corte. Foi conduzido um experimento com duas densidades de alojamento (11,07 e 13,21 aves/m²), e mensuradas variáveis de desempenho, qualidade de cama e incidência de lesões podais. A análise de fatores gerou 3 autovalores que acumularam 80,4% variância total dos dados. O Fator 1 (41,6% da variância) foi o único estatisticamente significativo pela análise de variância, e agrupou todas as variáveis relacionadas com umidade de cama e graus de lesão podal, mostrando haver uma inter-relação entre as mesmas. Estes dois grupos de variáveis foram utilizados na análise de componentes principais. Os dois primeiros componentes principais gerados acumularam 86,5% da variância total dos dados, e sua epresentação gráfica agrupou variáveis de umidade de cama e os graus mais severos de lesão podal com a maior densidade de alojamento. A análise multivariada utilizada foi eficiente no desdobramento das inter-relações entre as variáveis e demonstrou que o aumento da densidade de alojamento foi determinante na maior incidência de lesões por pododermatite e sua relação com a maior umidade da cama. This study aimed to evaluate the use of multivariate statistics to analyze a data set of different animal densities in broiler chickens. Was conducted an experiment with two animal densities (11.07 and 13.21 birds/m²); the variables measured were performance, litter quality and incidence of foot pad dermatitis. Factor analysis generated three eigenvalues which accumulated 80.4% of the total variance. Factor 1 (41.6 % of variance) was the only statistically significant by analysis of variance, and grouped all variables related to litter moisture and degrees of foot pad dermatitis, showing that there is a relationship between them. These two groups of variables wereused in the principal components analysis. The first two principal components generated accumulated 86.5% of the total variance of the data and their graphical representation grouped variables related to litter moisture and the most severe degrees of foot pad dermatitis with the highest density of housing. The multivariate analysis used was efficient in the deployment of inter-relationships between variab les and showed that increased housing density was determinant in the increased incidence of pododermatitis injuries and its relation to higher litter moisture

Open surgical partial nephrectomy for upper tract urothelial carcinoma

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/106973/1/iju12301.pd

Gross Motor Development, Movement Abnormalities, and Early Identification of Autism

Gross motor development (supine, prone, rolling, sitting, crawling, walking) and movement abnormalities were examined in the home videos of infants later diagnosed with autism (regression and no regression subgroups), developmental delays (DD), or typical development. Group differences in maturity were found for walking, prone, and supine, with the DD and Autism-No Regression groups both showing later developing motor maturity than typical children. The only statistically significant differences in movement abnormalities were in the DD group; the two autism groups did not differ from the typical group in rates of movement abnormalities or lack of protective responses. These findings do not replicate previous investigations suggesting that early motor abnormalities seen on home video can assist in early identification of autism

Diagnostic stability in young children at risk for autism spectrum disorder:A baby siblings research consortium study

BACKGROUND: The diagnosis of autism spectrum disorder (ASD) made before age 3 has been found to be remarkably stable in clinic- and community-ascertained samples. The stability of an ASD diagnosis in prospectively ascertained samples of infants at risk for ASD due to familial factors has not yet been studied, however. The American Academy of Pediatrics recommends intensive surveillance and screening for this high-risk group, which may afford earlier identification. Therefore, it is critical to understand the stability of an ASD diagnosis made before age 3 in young children at familial risk. METHODS: Data were pooled across 7 sites of the Baby Siblings Research Consortium. Evaluations of 418 later-born siblings of children with ASD were conducted at 18, 24, and 36 months of age and a clinical diagnosis of ASD or Not ASD was made at each age. RESULTS: The stability of an ASD diagnosis at 18 months was 93% and at 24 months was 82%. There were relatively few children diagnosed with ASD at 18 or 24 months whose diagnosis was not confirmed at 36 months. There were, however, many children with ASD outcomes at 36 months who had not yet been diagnosed at 18 months (63%) or 24 months (41%). CONCLUSIONS: The stability of an ASD diagnosis in this familial-risk sample was high at both 18 and 24 months of age and comparable with previous data from clinic- and community-ascertained samples. However, almost half of children with ASD outcomes were not identified as being on the spectrum at 24 months and did not receive an ASD diagnosis until 36 months. Thus, longitudinal follow-up is critical for children with early signs of social-communication difficulties, even if they do not meet diagnostic criteria at initial assessment. A public health implication of these data is that screening for ASD may need to be repeated multiple times in the first years of life. These data also suggest that there is a period of early development in which ASD features unfold and emerge but have not yet reached levels supportive of a diagnosis

Insulin-degrading enzyme Is a non proteasomal target of carfilzomib and affects the 20S proteasome inhibition by the drug

Carfilzomib is a last generation proteasome inhibitor (PI) with proven clinical efficacy in the treatment of relapsed/refractory multiple myeloma. This drug is considered to be extremely specific in inhibiting the chymotrypsin-like activity of the 20S proteasome, encoded by the β5 subunit, overcoming some bortezomib limitations, the first PI approved for multiple myeloma therapy which is however burdened by a significant toxicity profile, due also to its off-target effects. Here, molecular approaches coupled with molecular docking studies have been used to unveil that the Insulin-Degrading Enzyme, a ubiquitous and highly conserved Zn2+ peptidase, often found to associate with proteasome in cell-based models, is targeted by carfilzomib in vitro. The drug behaves as a modulator of IDE activity, displaying an inhibitory effect over 10-fold lower than for the 20S. Notably, the interaction of IDE with the 20S enhances in vitro the inhibitory power of carfilzomib on proteasome, so that the IDE-20S complex is an even better target of carfilzomib than the 20S alone. Furthermore, IDE gene silencing after delivery of antisense oligonucleotides (siRNA) significantly reduced carfilzomib cytotoxicity in rMC1 cells, a validated model of Muller glia, suggesting that, in cells, the inhibitory activity of this drug on cell proliferation is somewhat linked to IDE and, possibly, also to its interaction with proteasome

Acute presentation of a solitary caecal diverticulum: a case report

which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Introduction: Solitary caecal diverticulitis is a rare cause of abdominal pain in Caucasian patients. The condition is often misdiagnosed and only correctly identified on exploration for suspected acute appendicitis. Our aim is to improve awareness of this condition amongst surgical trainees to ensure that its first encounter is not in the operating theatre. We review the role of pre-operative radiological imaging in this condition and the wide and controversial management options are als

Desempenho de um sistema integrado de produção agropecuária sobre pastagem de inverno.

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CT colonography reporting and data system: A consensus proposal

We have proposed a practical reporting scheme that includes recommendations for the follow-up of colonic polyps that are based on currently available published assessments of the clinical importance and expected growth potential of these lesions. © RSNA, 2005

Nuclear factor erythroid 2-related factor 2 nuclear translocation induces myofibroblastic dedifferentiation in idiopathic pulmonary fibrosis

AIMS: Oxidants have been implicated in the pathophysiology of idiopathic pulmonary fibrosis (IPF), especially in myofibroblastic differentiation. We aimed at testing the hypothesis that nuclear factor erythroid 2-related factor 2 (Nrf2), the main regulator of endogenous antioxidant enzymes, is involved in fibrogenesis via myofibroblastic differentiation. Fibroblasts were cultured from the lungs of eight controls and eight IPF patients. Oxidants-antioxidants balance, nuclear Nrf2 expression, and fibroblast phenotype (α-smooth muscle actin and collagen I expression, proliferation, migration, and contraction) were studied under basal conditions and after Nrf2 knockdown or activation by Nrf2 or Keap1 siRNA transfection. The effects of sulforaphane (SFN), an Nrf2 activator, on the fibroblast phenotype were tested under basal and pro-fibrosis conditions (transforming growth factor β [TGF-β]). RESULTS: Decreased Nrf2 expression was associated with a myofibroblast phenotype in IPF compared with control fibroblasts. Nrf2 knockdown induced oxidative stress and myofibroblastic differentiation in control fibroblasts. Conversely, Nrf2 activation increased antioxidant defences and myofibroblastic dedifferentation in IPF fibroblasts. SFN treatment decreased oxidants, and induced Nrf2 expression, antioxidants, and myofibroblastic dedifferentiation in IPF fibroblasts. SFN inhibited TGF-β profibrotic deleterious effects in IPF and control fibroblasts and restored antioxidant defences. Nrf2 knockdown abolished SFN antifibrosis effects, suggesting that they were Nrf2 mediated. INNOVATION AND CONCLUSION: Our findings confirm that decreased nuclear Nrf2 plays a role in myofibroblastic differentiation and that SFN induces human pulmonary fibroblast dedifferentiation in vitro via Nrf2 activation. Thus, Nrf2 could be a novel therapeutic target in IPF