Estimation of energy and material use of sintering-based construction for a lunar outpost - with the example of SinterHab module design

In this paper, we would revisit the usability of microwave for lunar regolith sintering through an in-depth experiment, and examine the minimum materials and energy required for sintering based on the SinterHab design. This will include the minimum layers to print, estimated printing time, minimum energy required for the sintering process and the potential energy sources

A variety of lepton number violating processes related to Majorana neutrino masses

A Majorana type of the neutrino mass matrix induces a class of lepton number violating processes. Cross sections of these reactions are given in terms of the neutrino mass matrix element, and a semi-realistic event rate is estimated. These processes provide mass and mixing parameters not directly accessible by the neutrino oscillation experiments. If these processes are discovered with a larger rate than given here, it would imply a new physics of the lepton number violation not directly related to the Majorana neutrino mass, such as R-parity violating operators in SUSY models.Comment: 15 pages, 1 figur

Kinetics and moving species during Co2Si formation by rapid thermal annealing

We have investigated the growth kinetics and identified the moving species during Co2Si formation by rapid thermal annealing (RTA). For the kinetics study, samples which consisted of a thin Co film on an evaporated Si substrate were used. To study which species moves, samples imbedded with two very thin Ta markers were employed. Upon RTA, only one silicide phase, Co2Si, was observed to grow before all Co was consumed. The square root of time dependence and the activation energy of about 2.1±0.2 eV were observed during the Co2Si formation up to 680 °C. The marker study indicated that Co is the dominant mobile species during Co2Si formation by RTA. We conclude that Co2Si grows by the same mechanisms during RTA and conventional thermal annealing

Silicon resistor to measure temperature during rapid thermal annealing

A resistor composed of a piece of Si wafer and two thin silver wires attached to it, can reliably sense the temperature during rapid thermal annealing (RTA). As constant electric current passes through the Si piece, the resistivity change of Si with temperature produces a voltage signal that can be readily calibrated and converted to an actual temperature of the samples. An accuracy better than ±10 °C is achieved between 300° and 600 °C

Supporting memory and identity in older people: findings from a ‘Sandpit’ process

Identity in old age is challenged by physical changes, evolving roles within the family, and life transitions such as retirement. Supporting identity is therefore important in later life, and might be assisted by media technologies which allow people to reflect on their lives, record their personal histories and share these with family, friends and caregivers. This possibility was explored in two creative ‘Sandpits’ with older people as part of the SUS-IT project, funded by the New Dynamics of Ageing programme in the UK. Discussions were held with PC and non-PC user groups of retirement age to understand memory and identity practices and elicit reactions to three novel product concepts. These included a Reminiscing Radio for life review, a Story Lamp for associating spoken stories with photographs and memorabilia, and a pair of virtual reality Travel Glasses for transporting you back to a special place in the past. The main findings of these discussions will be presented, along with concepts generated by the participants in a re-design exercise. This paper will also show how the sandpits enabled older people to be involved in the design process by allowing them to shape early design concepts through exploring their own ideas and motivations

Mechanical compatibility of sol–gel annealing with titanium for orthopaedic prostheses

Sol–gel processing is an attractive method for large-scale surface coating due to its facile and inexpensive preparation, even with the inclusion of precision nanotopographies. These are desirable traits for metal orthopaedic prostheses where ceramic coatings are known to be osteoinductive and the effects may be amplified through nanotexturing. However there are a few concerns associated with the application of sol–gel technology to orthopaedics. Primarily, the annealing stage required to transform the sol–gel into a ceramic may compromise the physical integrity of the underlying metal. Secondly, loose particles on medical implants can be carcinogenic and cause inflammation so the coating needs to be strongly bonded to the implant. These concerns are addressed in this paper. Titanium, the dominant material for orthopaedics at present, is examined before and after sol–gel processing for changes in hardness and flexural modulus. Wear resistance, bending and pull tests are also performed to evaluate the ceramic coating. The findings suggest that sol–gel coatings will be compatible with titanium implants for an optimum temperature of 500 °C

Free Form Lensing Implications for the Collision of Dark Matter and Gas in the Frontier Fields Cluster MACSJ0416.1-2403

We present a free form mass reconstruction of the massive lensing cluster MACSJ0416.1-2403 using the latest Hubble Frontier Fields data. Our model independent method finds that the extended lensing pattern is generated by two elongated, closely projected clusters of similar mass. Our lens model identifies new lensed images with which we improve the accuracy of the dark matter distribution. We find that the bimodal mass distribution is nearly coincident with the bimodal X-ray emission, but with the two dark matter peaks lying closer together than the centroids of the X-ray emisison. We show this can be achieved if the collision has occurred close to the plane and such that the cores are deflected around each other. The projected mass profiles of both clusters are well constrained because of the many interior lensed images, leading to surprisingly flat mass profiles of both components in the region 15-100 kpc. We discuss the extent to which this may be generated by tidal forces in our dynamical model which are large during an encounter of this type as the cores "graze" each other. The relative velocity between the two cores is estimated to be about 1200 km/s and mostly along the line of sight so that our model is consistent with the relative redshift difference between the two cD galaxies (dz = 0.04).Comment: 22 pages, 18 figures, 2 table

The clinical effectiveness and cost-effectiveness of inhaler devices used in the routine management of chronic asthma in older children: a systematic review and economic evaluation

Background: This review examines the clinical effectiveness and cost-effectiveness of hand-held inhalers to deliver medication for the routine management of chronic asthma in children aged between 5 and 15 years. Asthma is a common disease of the airways, with a prevalence of treated asthma in 5–15-year-olds of around 12% and an actual prevalence in the community as high as 23%. Treatment for the condition is predominantly by inhalation of medication. There are three main types of inhaler device, pressurised metered dose, breath actuated, and dry powder, with the option of the attachment of a spacer to the first two devices under some prescribed circumstances. Two recent reviews have examined the clinical and cost-effectiveness evidence on inhaler devices, but one was for children aged under 5 years and the comparison in the second was made between pressurised metered dose inhalers and other types only. Objectives: This review examines the clinical effectiveness and cost-effectiveness of manual pressurised metered dose inhalers, breath-actuated metered dose inhalers, and breath-actuated dry powder inhalers, with and without spacers as appropriate, to deliver medication for the routine management of chronic asthma in children aged between 5 and 15 years. Methods: Two previous HTA reviews have compared the effectiveness of inhaler devices, one focusing on asthma in children aged under 5 years and the other on asthma and chronic obstructive airways disease in all age groups. For the current review, a literature search was carried out to identify all evidence relating to the use of inhalers in older children with chronic asthma. A search of in-vitro studies undertaken for one of the previous reviews was also updated. The data sources used were: 15 electronic bibliographic databases; the reference lists of one of the previous HTA reports and other relevant articles; health services research-related internet resources; and all sponsor submissions. Studies were selected according to strict inclusion and exclusion criteria, and relevant information concerning effectiveness and patient compliance and preference was extracted directly on to an extraction/evidence table. Quality assurance was monitored. Economic evaluation was undertaken by reviewing existing cost-effective evidence. Further economic modelling was carried out, and tables constructed to determine device cost-minimisation and incremental quality-adjusted life-year (QALY) thresholds between devices. Results: Number and quality of studies, and direction of evidence: Fourteen randomised controlled studies were identified relating to the clinical effectiveness of inhaler devices for delivering β2-agonists. A further five were on devices delivering corticosteroids and one concerned the delivery of cromoglicate. Overall, there were no differences in clinical efficacy between inhaler devices, but a pressurised metered dose inhaler with a spacer would appear to be more effective than one without. These findings endorse those of a previous HTA review but extend them to other inhaler devices. Seven randomised controlled trials examined the impact on clinical effectiveness of using a nonchlorofluorocarbon (CFC) propellant in place of a CFC propellant in metered dose inhalers, both pressurised and breath activated, although only one study considered the latter type. No differences were found between inhalers containing either propellant. A further 30 studies of varying quality, from 12 randomised controlled trials to non-controlled studies, were identified that concerned the impact of use by, and preference for, inhaler type, and treatment adherence in children. Differences between the studies, and limitations in comparative data between various inhaler device types, make it difficult to draw any firm conclusions from this evidence. Summary of benefits: No obvious benefits for one inhaler device type over another for use in children aged 5–15 years were identified. Costs and cost per quality-adjusted life-year: Two approaches have been taken: cost-minimisation and QALY threshold. In the QALY threshold approach, additional QALYs that each device must produce compared with a cheaper device to achieve an acceptable cost per QALY were calculated. Using the cheapest and most expensive devices for delivering 200 μg of beclometasone per day, assuming no cost offset for any device, and a threshold of £5000, the largest QALY needed was 0.00807. With such a small QALY increase, no intervention can be categorically rejected as not cost-effective. Conclusions: Generalisability of findings: On the available evidence there are no obvious benefits for one inhaler device over another when used by children aged 5–15 years with chronic asthma. However, the evidence, in the majority of cases, was compiled on children with mild to moderate asthma and restricted to a limited number of drugs. Therefore the findings may not be generalisable to those at the more severe end of the spectrum of the disease or to inhaler devices delivering some of the drugs used in the management of asthma. Need for further research: Many of the previous studies are likely to have been underpowered. Further clinical trials with a robust methodology, sufficient power and qualitative components are needed to demonstrate any differences in clinical resource use and patients’ asthma symptoms. Further studies should also include the behavioural aspects of patients towards their medication and its delivery mechanisms. It is acknowledged that sufficient power may prove impractical owing to the large numbers of patients required

Millimeter and hard x ray/gamma ray observations of solar flares during the June 1991 GRO campaign

We have carried out high-spatial-resolution millimeter observations of solar flares using the Berkeley-Illinois-Maryland Array (BIMA). At the present time, BIMA consists of only three elements, which is not adequate for mapping highly variable solar phenomena, but is excellent for studies of the temporal structure of flares at millimeter wavelengths at several different spatial scales. We present BIMA observations made during the Gamma Ray Observatories (GRO)/Solar Max 1991 campaign in Jun. 1991 when solar activity was unusually high. Our observations covered the period 8-9 Jun. 1991; this period overlapped the period 4-15 Jun. when the Compton Telescope made the Sun a target of opportunity because of the high level of solar activity

Resolving Structure in Human Brain Organization: Identifying Mesoscale Organization in Weighted Network Representations

Human brain anatomy and function display a combination of modular and hierarchical organization, suggesting the importance of both cohesive structures and variable resolutions in the facilitation of healthy cognitive processes. However, tools to simultaneously probe these features of brain architecture require further development. We propose and apply a set of methods to extract cohesive structures in network representations of brain connectivity using multi-resolution techniques. We employ a combination of soft thresholding, windowed thresholding, and resolution in community detection, that enable us to identify and isolate structures associated with different weights. One such mesoscale structure is bipartivity, which quantifies the extent to which the brain is divided into two partitions with high connectivity between partitions and low connectivity within partitions. A second, complementary mesoscale structure is modularity, which quantifies the extent to which the brain is divided into multiple communities with strong connectivity within each community and weak connectivity between communities. Our methods lead to multi-resolution curves of these network diagnostics over a range of spatial, geometric, and structural scales. For statistical comparison, we contrast our results with those obtained for several benchmark null models. Our work demonstrates that multi-resolution diagnostic curves capture complex organizational profiles in weighted graphs. We apply these methods to the identification of resolution-specific characteristics of healthy weighted graph architecture and altered connectivity profiles in psychiatric disease.Comment: Comments welcom