Echinococcosis of dogs in the North Caucasian Subjects (infrastructural, epizootological and sanitary-hygienic analysis)

Based on the official statistics the situation of parasitic diseases in the Russian Federation is still quite unfavorable. The issues of soil contamination with Echinococcus granulosus eggs are understudied that’s why the objective of the research was to study canine echinococcosis which poses a threat to animal and human disease freedom in the North Caucasian countries. Helminthological tests of the guardian dog feces were performed in seven North Caucasian Subjects: the Stavropol Krai, the Karachay-Cherkessia Republic, the Kabardino-Balkaria Republic, Republic of North Ossetia −Alania, Republic of Ingushetia, the Chechen Republic, and the Republic of Dagestan. As a result, it was determined that the average frequency index of echinococcosis occurrence was 85.07%. The moderate fecal egg count in 1,400 samples was 22.73 ± 1.49 eggs per 10 grams of dog feces. The data obtained are indicative of the disease unfavourable situation in the Subjects and the zoonosis spread at the regional level. Helminthological tests of 14,000 soil samples from near-village pastures for contamination with tapeworm eggs, including Echinococcus granulosus, showed that the invasion rate in the Stavropol Krai was 65.80%, in Karachay-Cherkessia republic − 79.00%, in Kabardino-Balkaria − 82.60%, in North Ossetia − Alania − 74.65%, in Ingushetia − 88.20%, in Chechnya − 83.75%, in Dagestan − 79.85%. The results obtained testify to the high level of soil contamination with the infective eggs. It was demonstrated that there is a relationship between the distribution of viable Echinococcus granulosus eggs in pasture soils and ecological characteristics of the Subject: the largest number of viable Echinococcus granulosus eggs was observed in submountain areas, fewer eggs were observed in flatlands, and the least number of eggs – in the mountain areas. The number of eggs detected in the soil samples from pastures is indicative of the disease persistence in humans and animals. Results of the helminthological tests of 7,500 soil samples from 119 cattle-driving routes of the North Caucasus demonstrate 100% contamination with parasitic agents which poses a threat of epidemiological and epizootological situation of echinococcosis in the Subject

Analysis of the Causes for Renal Dysfunction during Antibiotic Therapy in a Patient with Lyme Disease

Adverse drug reactions (ADRs) are recorded throughout the lifecycle of a medicinal product. In the post-marketing period, new ADRs are primarily identified via drug safety signals. In order to assess a signal and establish causality between an adverse drug reaction and a suspected medicinal product, it is necessary to evaluate the signal strength and quality.The aim of the study was to analyse the information submitted to Russian regulatory authorities by a patient and check it for a potential causal association of acute tubulointerstitial nephritis (ATIN) with the use of ceftriaxone and with the patient’s principal diagnosis, Lyme disease.Materials and methods: the authors analysed the patient’s submission received by the Ministry of Health of the Russian Federation in 2022 with a complaint that the treatment of Lyme disease with ceftriaxone had caused ATIN. The probability of a causal relationship between the medicinal product and the ADR was evaluated using the Naranjo algorithm.Results: according to the review of literature and the spontaneous reports collected in Pharmacovigilance 2.0, the database in the Automated Information System of the Russian Federal Service for Surveillance in Healthcare, both ceftriaxone and the underlying condition (Lyme disease) may cause renal abnormalities. Ceftriaxone is potentially nephrotoxic; it mainly affects the tubular system of the kidneys. Borreliosis may cause kidney damage as well; such damage manifests clinically as rapidly progressing and fatal damage to the glomeruli.Conclusions: the probability of a causal relationship between the development of ATIN in the complainant and the use of ceftriaxone was categorised as “possible”. However, the information available did not allow for establishing a definite relationship between kidney damage and the use of the medicinal product. Further monitoring of similar cases is necessary to minimise the risks of developing this pathology during treatment with ceftriaxone