PRICKLE1-related early onset epileptic encephalopathy

The PRICKLE1 (Prickle Planar Cell Polarity Protein 1-MIM 608500) gene is involved in different phases of human development. The related diseases include autosomal recessive progressive myoclonus epilepsy - ataxia syndrome, neural tube defects associated with heterozygous mutations, agenesis of corpus callosum, polymicrogyria, and autistic spectrum disorder. Reported here is a young boy with a new variant (NM_153026.2:c.820G>A, p.Ala274Thr) presenting with an early infantile epileptic encephalopathy with developmental arrest

Body, Sign and Double: a Parallel Analysis of Elaine Shemilt’s Doppelganger, Federica Marangoni’s The Box of Life and Sanja Ivekovic ́’s Instructions N°1 and Make up - Make down

Body, identity, self-representation, sexuality, stereotypical images of women portrayed by the society and the media, and the condition of female professional artists: these themes were expressed and developed in several early video works in the 70s and early 80s by women artists that didn’t have direct knowledge or contact between each other. This simultaneity of thematic is an unusual phenomenon that reveals common, contemporary sensibilities within both Europe and the USA

Approaches, Strategies and Theoretical and Practice-Based Research Methods to investigate and archive video art:Some reflections from the REWIND projects

This paper will discuss methodologies, approaches and issues, emerging out of three major research projects that have investigated early histories of video art in Europe: REWIND (2004 ongoing), REWINDItalia (2011-2014) and EWVA (2015-2018). The paper will discuss how the projects have engaged with the history of the apparatus, the identity and status of the artworks, preservation methods, and the legacy of these video artworks today. A particular focus will be on semi-structured questionnaires for interviews structured to capture oral histories, memories and recollections, that in some cases would have been otherwise lost to future knowledge and the uncovering of lost artworks and their available documentation. The speakers directly involved in the projects - will discuss solutions, risks and experiences encountered in the projects and future research perspectives for re-covering, collecting, archiving and narrating the histories of early video art in Europe. The paper will discuss also different practice-based research methods, platforms and engagement strategies, including re-installation and re-enactment

Dynamic Response of Cantilever Retaining Walls Considering Soil Non-Linearity

For many decades the analysis of earth retaining structures under dynamic or seismic conditions has been carried out by means of standard limit equilibrium (Coulomb, M-O) or elastic methods (Wood, Veletsos and Younan). These approaches are simplified, as they make use of considerable approximations which are often applicable only under particular conditions. A different and perhaps more realistic approach is possible using established computer codes, which integrate numerically the governing equations of the soil and wall media. Since these problems may involve significant levels of strain in the backfill, material non-linearity should be taken into account to realistically simulate the response of the system. In the herein-reported study, a parametric analysis is carried out through the finite-difference code FLAC 5.0. Starting from simple cases involving elastic response, and moving gradually towards more realistic conditions, salient features of the dynamic wall-soil interaction problem are addressed. The case of non-linear hysteretic behaviour of soil and flexibility of wall is considered at a second stage. Results indicate that with increasing levels of acceleration, there is a clear transition from elastic behaviour (in which the aforementioned V-Y type methods are applicable), to plastic behaviour in which M-O methods are thought to be more suitable under pseudo-static conditions. The results of the parametric analyses are reported in terms of pertinent normalized parameters, to provide a general framework for the assessment of wall-soil dynamic interaction under strong seismic excitation

Talc pleurodesis by flexi-rigid thoracoscope under local anaesthesia: visual talc slurry?

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Primary palmar hyperhidrosis: double-stage three levels clipping

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The spherical 2+p spin glass model: an analytically solvable model with a glass-to-glass transition

We present the detailed analysis of the spherical s+p spin glass model with two competing interactions: among p spins and among s spins. The most interesting case is the 2+p model with p > 3 for which a very rich phase diagram occurs, including, next to the paramagnetic and the glassy phase represented by the one step replica symmetry breaking ansatz typical of the spherical p-spin model, other two amorphous phases. Transitions between two contiguous phases can also be of different kind. The model can thus serve as mean-field representation of amorphous-amorphous transitions (or transitions between undercooled liquids of different structure). The model is analytically solvable everywhere in the phase space, even in the limit where the infinite replica symmetry breaking ansatz is required to yield a thermodynamically stable phase.Comment: 21 pages, 18 figure

Statistical mechanics of glass transition in lattice molecule models

Lattice molecule models are proposed in order to study statistical mechanics of glass transition in finite dimensions. Molecules in the models are represented by hard Wang tiles and their density is controlled by a chemical potential. An infinite series of irregular ground states are constructed theoretically. By defining a glass order parameter as a collection of the overlap with each ground state, a thermodynamic transition to a glass phase is found in a stratified Wang tiles model on a cubic lattice.Comment: 18 pages, 8 figure