3 research outputs found
An antiproliferative norditerpene dilactone, Nagilactone C, from Podocarpus neriifolius
No full textAn ethanolic extract of Podocarpus neriifolius D. Don (Podocarpaceae) showed antiproliferative activity against two major tumor cell lines, viz. human HT-1080 fibrosarcoma and murine color 26-L5 carcinoma. Bioassay guided fractionation showed the highest antiproliferative activity in chloroform\u2013soluble fraction. Nagilactone C, the major constituent of this fraction was isolated and characterized by using NMR, IR and FAB-MS spectroscopic methods. Nagilactone C possessed potent antiproliferative activity against human fibrosarcoma and murine colon carcinoma tumor cell lines exhibiting ED50 values of 2.3 and 1.2 \u3bcg/ml, respectively. Hence, nagilactone C could be the active constituent present in this plant.Peer reviewed: YesNRC publication: N
