Léiomyosarcome de la veine rénale gauche dans un contexte de polyarthrite rhumatoïde sous méthotrexate

RésuméLe léiomyosarcome de la veine rénale est une tumeur maligne exceptionnelle dont la détection est délicate, le traitement mal codifié et le pronostic sombre. Nous décrivons le cas d’une patiente de 68 ans atteinte de polyarthrite rhumatoïde et développant un léiomyosarcome de la veine rénale gauche avec une issue fatale en moins d’un an. L’association à une polyarthrite rhumatoïde traitée par méthotrexate pose donc la question d’une combinaison fortuite ou d’un terrain favorisant compte tenu des études récentes qui tendent à prouver l’association entre ce rhumatisme et certains cancers

In vivo measurements of atrial repolarization alternans based on standard pacemaker technology

It has been shown that repolarization alternans, a beat-to-beat alternation in action potential duration, enhances dispersion of repolarization above a critical heart rate and promotes susceptibility to ventricular arrhythmias. It is unknown whether repolarization alternans is measurable in the atria using standard pacemakers and whether it plays a role in promoting atrial fibrillation. In this work, atrial repolarization alternans amplitude and periodicity are studied in a sheep model of pacing-induced atrial fibrillation. Two pacemakers, each with one right atrial and ventricular lead, were implanted in 4 male sheep after ablation of the atrioventricular junction. The first one was used to deliver rapid pacing for measurements of right atrial repolarization alternans and the second one to record a unipolar electrogram. Atrial repolarization alternans appeared rate-dependent and its amplitude increased as a function of pacing rate. Repolarization alternans was intermittent but no periodicity was detected. An increase of repolarization alternans preceding episodes of non-sustained atrial fibrillation suggests that repolarization alternans is a promising parameter for assessment of atrial fibrillation susceptibility

Full-genome sequence of the plant growth-promoting bacterium Pseudomonas protegens CHA0.

We report the complete genome sequence of the free-living bacterium Pseudomonas protegens (formerly Pseudomonas fluorescens) CHA0, a model organism used in plant-microbe interactions, biological control of phytopathogens, and bacterial genetics

Selection rules in three-body B decay from factorization

Extending the dynamics underlying the factorization calculation of two-body decays, we propose simple selection rules for nonresonant three-body B decays. We predict, for instance, that in the Dalitz plot of B^0-->D^0-bar\pi^+\pi^-, practically no events should be found in the corner of E(\pi^+) < \Lambda_{QCD} as compared with the corner of E(\pi^-) < \Lambda_{QCD}. We also predict that there should be very few three-body decay events with a soft meson resonance and two energetic mesons or meson resonances. The selection rules are quite different from the soft pion theorem, since they apply to different kinematical regions. For B^0 -->D^0-bar\pi^+\pi^-, the latter predicts that the decay matrix element vanishes in the zero-four-momentum limit of \pi^+ instead of \pi^-. Since this marked difference from the soft pion theorem is directly related to the issue of short-distance QCD dominance in the FSI of two-body B decays, experimental test of the selection rules will shed light on strong interaction dynamics of B decay.Comment: 12 pages in REVTEX including 3 eps figure

Pseudomonas fluorescens CHA0 maintains carbon delivery to Fusarium graminearum-infected roots and prevents reduction in biomass of barley shoots through systemic interactions

Soil bacteria such as pseudomonads may reduce pathogen pressure for plants, both by activating plant defence mechanisms and by inhibiting pathogens directly due to the production of antibiotics. These effects are hard to distinguish under field conditions, impairing estimations of their relative contributions to plant health. A split-root system was set up with barley to quantify systemic and local effects of pre-inoculation with Pseudomonas fluorescens on the subsequent infection process by the fungal pathogen Fusarium graminearum. One root half was inoculated with F. graminearum in combination with P. fluorescens strain CHA0 or its isogenic antibiotic-deficient mutant CHA19. Bacteria were inoculated either together with the fungal pathogen or in separate halves of the root system to separate local and systemic effects. The short-term plant response to fungal infection was followed by using the short-lived isotopic tracer 11CO2 to track the delivery of recent photoassimilates to each root half. In the absence of bacteria, fungal infection diverted carbon from the shoot to healthy roots, rather than to infected roots, although the overall partitioning from the shoot to the entire root system was not modified. Both local and systemic pre-inoculation with P. fluorescens CHA0 prevented the diversion of carbon as well as preventing a reduction in plant biomass in response to F. graminearum infection, whereas the non-antibiotic-producing mutant CHA19 lacked this ability. The results suggest that the activation of plant defences is a central feature of biocontrol bacteria which may even surpass the effects of direct pathogen inhibition

Intermittent atrial tachycardia facilitates atrial fibrillation by a shortening of activation recovery interval

Introduction: We recently observed in a chronic ovine model that a shortening of action potential duration (APD) as assessed by the activation recovery interval (ARI) may be a mechanism whereby pacing-induced atrial tachycardia (PIAT) facilitates atrial fibrillation (AF), mediated by a return to 1:1 atrial capture after the effective refractory period has been reached. The aim of the present study is to evaluate the effect of long term intermittent burst pacing on ARI before induction of AF.Methods: We specifically developed a chronic ovine model of PIAT using two pacemakers (PM) each with a right atrial (RA) lead separated by ∼2cm. The 1st PM (Vitatron T70) was used to record a broadband unipolar RA EGM (800 Hz, 0.4 Hz high pass filter). The 2nd was used to deliver PIAT during electrophysiological protocols at decremental pacing CL (400 beats, from 400 to 110ms) and long term intermittent RA burst pacing to promote electrical remodeling (5s of burst followed by 2s of sinus rhythm) until onset of sustained AF. ARI was defined as the time difference between the peak of the atrial repolarization wave and the first atrial depolarization. The mean ARIs of paired sequences (before and after remodeling), each consisting of 20 beats were compared.Results: As shown in the figure, ARIs (n=4 sheep, 46 recordings) decreased post remodeling compared to baseline (86±19 vs 103±12 ms, p&lt;0.05). There was no difference in atrial structure as assessed by light microscopy between control and remodeled sheep.Conclusions: Using standard pacemaker technology, atrial ARIs as a surrogate of APDs were successfully measured in vivo during the electrical remodeling process leading to AF. The facilitation of AF by PIAT mimicking salvos from pulmonary veins is heralded by a significant shortening of ARI

Possible large phase in psi(2S) -> 1-0- Decays

The strong and the electromagnetic amplitudes are analyzed on the basis of the measurements of J/psi, psi(2S) -> 1-0- in e+e- experiments. The currently available experimental information is revised with inclusion of the contribution from e+e- -> gamma * -> 1-0- . The study shows that a large phase around minus 90 degree between the strong and the electromagnetic amplitudes could not be ruled out by the experimental data for psi(2S).Comment: 4 page

A possible hadronic excess in psi(2S) decay and rho-pi puzzle

We examine the so-called rho-pi puzzle of the psi(2S) decay by incorporating two inputs: One is the relative phase between the one-photon and the gluon decay amplitude, and the other is a possible anomaly in the inclusive nonelectromagnetic decay rate of psi(2S). We propose the possibility that in the psi(2S) decay a hadronic decay process of long distance origin is important in addition to the short-distance decay process. The amplitude of this additional process should nearly cancel the three-gluon amplitude in the exclusive psi(2S)---> 1-0- and turn the sum dominantly real in contrast to the J/psi decay. We present general consequences of this mechanism and then briefly look into two models which possibly explain the course of this additional amplitude.Comment: 14 pages, 2 Tables, and 3 eps figures. Replaces the original version with a minor change in the title and inclusion of more references. The version to appear in Phys. Rev.

Electromagnetic form factors in the J/\psi mass region: The case in favor of additional resonances

Using the results of our recent analysis of e^+e^- annihilation, we plot the curves for the diagonal and transition form factors of light hadrons in the time-like region up to the production threshold of an open charm quantum number. The comparison with existing data on the decays of J/\psi into such hadrons shows that some new resonance structures may be present in the mass range between 2 GeVand the J/\psi mass. Searching them may help in a better understanding of the mass spectrum in both the simple and a more sophisticated quark models, and in revealing the details of the three-gluon mechanism of the OZI rule breaking in K\bar K channel.Comment: Formulas are added, typo is corrected, the text is rearranged. Replaced to match the version accepted in Phys Rev

Twenty-five new viruses associated with the drosophilidae (Diptera)

Drosophila melanogaster is an important laboratory model for studies of antiviral immunity in invertebrates, and Drosophila species provide a valuable system to study virus host range and host switching. Here, we use metagenomic RNA sequencing of about 1600 adult flies to discover 25 new RNA viruses associated with six different drosophilid hosts in the wild. We also provide a comprehensive listing of viruses previously reported from the Drosophilidae. The new viruses include Iflaviruses, Rhabdoviruses, Nodaviruses, and Reoviruses, and members of unclassified lineages distantly related to Negeviruses, Sobemoviruses, Poleroviruses, Flaviviridae, and Tombusviridae. Among these are close relatives of Drosophila X virus and Flock House virus, which we find in association with wild Drosophila immigrans. These two viruses are widely used in experimental studies but have not been previously reported to naturally infect Drosophila. Although we detect no new DNA viruses, in D. immigrans and Drosophila obscura, we identify sequences very closely related to Armadillidium vulgare iridescent virus (Invertebrate iridescent virus 31), bringing the total number of DNA viruses found in the Drosophilidae to three.This work was funded by a Wellcome Trust Research Career Development Fellowship (WT085064) to DJO. BL was supported by grants from the UK Natural Environment Research Council (NE/L004232/1) and the European Research Council (281668, Drosophila Infection). SHL was supported by a Natural Environment Research Council Doctoral Training Grant (NERC DG NE/J500021/1). Work in DJO’s laboratory is partly supported by a Wellcome Trust strategic award to the Centre for Immunity, Infection and Evolution (WT095831). The authors confirm that the funder had no influence over the study design, content of the article, or selection of this journal