Conducta agresiva e inteligencia emocional en la adolescencia

Son escasos los estudios que analizan la relación entre conducta agresiva e inteligencia emocional. Este estudio examina la relación entre inteligencia emocional rasgo y los componentes motor (agresividad física y agresividad verbal), cognitivo (hostilidad) y afectivo/emocional (ira) de la conducta agresiva. El Trait Emotional Intelligence Questionnaire-Adolescents Short Form (TEIQue-ASF) y el Aggression Questionnaire Short version (AQ-S) fueron administrados a una muestra de 314 adolescentes (52.5% chicos) de 12 a 17 años. Los resultados indicaron que los adolescentes con altas puntuaciones en conducta agresiva física, verbal, hostilidad e ira presentaron puntuaciones significativamente más bajas en inteligencia emocional rasgo que sus iguales con puntuaciones bajas en conducta agresiva física, verbal, hostilidad e ira. Este patrón de resultados fue el mismo tanto para la muestra total como para chicos, chicas y los grupos de edad de 12-14 años y 15-17 años. Además, en la mayoría de los casos se hallaron tamaños del efecto grandes apoyando la relevancia empírica de estas diferencias.There are few studies examining the relationship between aggressive behavior and emotional intelligence. This study examines the relationship between trait emotional intelligence and behavioral (physical aggression and verbal aggression), cognitive (hostility) and affective/emotional (anger) components of aggressive behavior. The Trait Emotional Intelligence Questionnaire- Adolescents Short Form (TEIQue-ASF) and the Aggression Questionnaire Short (AQ-S) were administered to a sample of 314 adolescents (52.5% boys) aged 12 to 17 years. The results indicated that adolescents with high scores on physical and verbal aggression, hostility and anger showed significantly lower scores in trait emotional intelligence than their peers with low scores on physical and verbal aggression, hostility and anger. This pattern of results was the same for the total sample and for boys and girls and age groups of 12-14 years and 15-17 years. Furthermore, in most cases, large effect sizes were found supporting the empirical relevance of these differences

Taxanes convert regions of perturbed microtubule growth into rescue sites

Microtubules are polymers of tubulin dimers, and conformational transitions in the microtubule lattice drive microtubule dynamic instability and affect various aspects of microtubule function. The exact nature of these transitions and their modulation by anti -cancer drugs such as Taxol and epothilone, which can stabilize microtubules but also perturb their growth, are poorly understood. Here, we directly visualize the action of fluorescent Taxol and epothilone derivatives and show that microtubules can transition to a state that triggers cooperative drug binding to form regions with altered lattice conformation. Such regions emerge at growing microtubule ends that are in a pre-catastrophe state and inhibit microtubule growth and shortening. Electron microscopy and in vitro dynamics data indicate that taxane accumulation zones represent incomplete tubes that can persist, incorporate tubulin dimers and repeatedly induce microtubule rescues. Thus, taxanes modulate the material properties of microtubules by converting destabilized growing microtubule ends into regions resistant to depolymerization

Study protocol of a randomised clinical trial testing whether metacognitive training can improve insight and clinical outcomes in schizophrenia

Background: Although insight in schizophrenia spectrum disorders (SSD) has been associated with positive outcomes, the effect size of previous treatments on insight has been relatively small to date. The metacognitive basis of insight suggests that metacognitive training (MCT) may improve insight and clinical outcomes in SSD, although this remains to be established. Methods: This single-center, assessor-blind, parallel-group, randomised clinical trial (RCT) aims to investigate the efficacy of MCT for improving insight (primary outcome), including clinical and cognitive insight, which will be measured by the Schedule for Assessment of Insight (Expanded version) (SAI-E) and the Beck Cognitive Scale (BCIS), respectively, in (at least) n = 126 outpatients with SSD at three points in time: i) at baseline (T0); ii) after treatment (T1) and iii) at 1-year follow-up (T2). SSD patients receiving MCT and controls attending a non-intervention support group will be compared on insight level changes and several clinical and cognitive secondary outcomes at T1 and T2, whilst adjusting for baseline data. Ecological momentary assessment (EMA) will be piloted to assess functioning in a subsample of participants. Discussion: To the best of our knowledge, this will be the first RCT testing the effect of group MCT on multiple insight dimensions (as primary outcome) in a sample of unselected patients with SSD, including several secondary outcomes of clinical relevance, namely symptom severity, functioning, which will also be evaluated with EMA, hospitalizations and suicidal behaviour.This study was supported by the Universidad Autónoma de Madrid and European Union via the Intertalentum Project Grant-Marie Skłodowska Curie Actions (GA 713366) to JDLM who is the Princiapl Investigator. This grant therefore funds both JDLM’s salary and the consumable expenses related to the study. JDLM, VGRR, ASEM, MLBE, LMI, LML, SSA, AAR and EBG’s salaries come from the Hospital Universitario Fundación Jiménez Díaz, where this study is currently being carried out, which therefore provides the necessary institutional/departmental support for its development. Additional departmental support concerning the use of Ecological Momentary Assessment (see Methods section, page 11 -last paragraph- and page 12 –first paragraph-, for details) is provided by the Instituto de Salud Carlos III (Madrid, Spain) (ISCIII PI16/01852) and the Madrid Regional Government (Madrid, Spain) (B2017/BMD-3740 AGES-CM 2CM; Y2018/TCS-4705 PRACTICO-CM). ASD acknowledges funding supports from University College London, which covers his salar

Metas académicas y estrategias de aprendizaje en estudiantes españoles de Educación Secundaria Obligatoria con ansiedad social

The purpose of this study was to analyse the relationship between high social anxiety, academic goals and learning strategies in a sample of 2,022 (51.1% male) Spanish adolescents aged 12–16. The Social Phobia and Anxiety Inventory (SPAI), Achievement Goal Tendencies Questionnaire (AGTQ) and Learning and Studies Skills Strategies Inventory — High School Version (LASSI-HS) were used to assess the variables. The results showed no statistically significant differences in goal orientations between students with and without high social anxiety. However, students with high social anxiety used learning strategies significantly less. In addition, the logistic regression results indicated that high social anxiety acts as a significant predictor for setting social reinforcement goals and learning and study strategies.El objetivo de este estudio fue analizar la relación entre la alta ansiedad social, las metas académicas y las estrategias de aprendizaje en una muestra de 2,022 (51.1% varones) adolescentes españoles de 12 a 16 años. Las variables fueron evaluadas mediante los cuestionarios Social Phobia and Anxiety Inventory (SPAI), Achievement Goal Tendencies Questionnaire (AGTQ) y Learning And Studies Skills Inventory — High school (LASSI-HS). Los resultados no mostraron ninguna diferencia estadísticamente significativa en las orientaciones de meta entre estudiantes con y sin alta ansiedad social. No obstante, los estudiantes con alta ansiedad social utilizaron significativamente menos estrategias de aprendizaje. Asimismo, los resultados obtenidos de la regresión logística señalaron que la alta ansiedad social actúa como predictor significativo de las metas de reconocimiento social y de las estrategias de aprendizaje y estudio.This work has been funded by the SEJ 2004-07311/EDUC Project, under the Plan Nacional de Investigación Científica, Desarrollo de Innovación Tecnológica del MEC (MEC National Plan for Scientific Research and Technological Innovation Development). / Este artículo de investigación ha sido financiado a través del Proyecto SEJ 2004-07311/EDUC perteneciente al Plan Nacional de Investigación Científica, Desarrollo e Innovación Tecnológica del MEC

Validation of a Mass Spectrometry Method To Quantify Oak Ellagitannins in Wine Samples

[EN] Detection and individual quantification of oak wood ellagitannins in oak barrel aged red wine samples are difficult mainly due to their low levels and the similarity between their structures. In this work, a quantification method using mass spectrometry has been developed and validated to quantify wine ellagitannins after sample fractionation with a previously reported method. The use of an internal standard is a requirement to correct mass signal variability. (−)-Gallocatechin, among the different tested compounds, was the only one that proved to be a suitable internal standard making possible the accurate and individual quantification of the main oak wood ellagitannins. The developed methodology has been used to detect and quantify these ellagitannins in different Spanish commercial wines, proving its usefulness

How Much Nubia‐Eurasia Convergence Is Accommodated by the NE End of the Eastern Betic Shear Zone (SE Spain)? Constraints From GPS Velocities

We present the first GPS‐derived geodetic observations from the NE end of the Eastern Betic Shear Zone obtained from the Bajo Segura GPS network (SE Spain). The network has 11 GPS sites and was sampled four times between 1999 and 2013. Despite the low signal‐to‐noise ratio of the residual velocities obtained, the velocities are nonzero at 95% confidence level. We postulate that the GPS data point to the partitioning of deformation into the NNW–SSE shortening and a N70E left‐lateral component. The maximum deformation rates are located along the two main active faults in the study area. The maximum shortening rates (north component) in the southern region of the Bajo Segura Basin vary from west to east, ranging from 0.2 to 0.7 mm/year along the Bajo Segura Fault Zone. On the northern border of the basin, along the Crevillente Fault Zone, left‐lateral displacement varies between 0.4 and 0.7 mm/year in the E‐W direction. The GPS‐based regional geodynamic models of the Western Mediterranean indicate that the residual shortening of the Eurasia‐Nubia plate convergence is accommodated in the eastern part of the Iberian Peninsula and the Algero‐Balearic Basin. Our results indicate that part of this residual deformation occurs at the NE end of the Eastern Betic Shear Zone, but significant deformation must be accommodated also to the north (External Betics) and to the south (Cartagena Basin and offshore area). We postulate that Eurasia‐Nubia plate convergence is transferred to the Eastern Betics because of the thin and rigid (potentially oceanic) crust of the Algero‐Balearic Basin, which acts as an indenter.This research was funded by the Spanish Ministry of Economy and Competitiveness (research project CGL2011‐30153‐C02‐02), University of Alicante (research project VIGROB053), University of Jaén (PAIUJA 2019/2020, CEACTierra), and RNM282 Research Group of Junta de Andalucía

Comprehensive cross-platform comparison of methods for non-invasive EGFR mutation testing : results of the RING observational trial.

Abstract Several platforms for noninvasive EGFR testing are currently used in the clinical setting with sensitivities ranging from 30% to 100%. Prospective studies evaluating agreement and sources for discordant results remain lacking. Herein, seven methodologies including two next-generation sequencing (NGS)-based methods, three high-sensitivity PCR-based platforms, and two FDA-approved methods were compared using 72 plasma samples, from EGFR-mutant non-small-cell lung cancer (NSCLC) patients progressing on a first-line tyrosine kinase inhibitor (TKI). NGS platforms as well as high-sensitivity PCR-based methodologies showed excellent agreement for EGFR-sensitizing mutations (K = 0.80-0.89) and substantial agreement for T790M testing (K = 0.77 and 0.68, respectively). Mutant allele frequencies (MAFs) obtained by different quantitative methods showed an excellent reproducibility (intraclass correlation coefficients 0.86-0.98). Among other technical factors, discordant calls mostly occurred at mutant allele frequencies (MAFs) ≤ 0.5%. Agreement significantly improved when discarding samples with MAF ≤ 0.5%. EGFR mutations were detected at significantly lower MAFs in patients with brain metastases, suggesting that these patients risk for a false-positive result. Our results support the use of liquid biopsies for noninvasive EGFR testing and highlight the need to systematically report MAFs. Keywords: NGS; circulating free DNA; epidermal growth factor receptor; non-small-cell lung cancer; osimertinib; tyrosine kinase inhibitor

Proportionate flow shop games

htmlabstractIn a proportionate flow shop problem several jobs have to be processed through a fixed sequence of machines and the processing time of each job is equal on all machines. By identifying jobs with agents, whose costs linearly depend on the completion time of their jobs, and assuming an initial processing order on the jobs, we face two problems: the first one is how to obtain an optimal order that minimizes the total processing cost, the second one is how to allocate the cost savings obtained by ordering the jobs optimally. In this paper we focus on the allocation problem. PFS games are defined as cooperative games associated to proportionate flow shop problems. It is seen that PFS games have a nonempty core. Moreover, it is shown that PFS games are convex if the jobs are initially ordered in decreasing urgency. For this case an explicit game independent expression for the Shapley value is provid