4 research outputs found
Π€ΠΎΡΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠ°Ρ ΡΠ΅ΡΠ°ΠΏΠΈΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ ΡΠ΅ΠΉΠΊΠΈ ΠΌΠ°ΡΠΊΠΈ
The experience of treatment for precancer and early cervical cancer by photodynamic therapy in 12 patients with primary diagnosis H-SIL (CIN IIβIII) and cancer in situ is described. Chlo-rine photosensitizer Photolon was given intravenously at a dose of 0.75β1.15 mg/kg body weight. 2.5 h later the treatment with polyposition laser exposure (light dose β 150 J/cm2, light power density β 400β500 mW/cm2) was made. Thirty days later conization of the cervix with endocervical curettage assessing therapeutic response of cervical tumor tissue was per-formed. According to histological data complete response was in 4 patients, minute foci of CIN I were determined in 7 patients, 1 patient had foci of CIN II. 8 of 10 HPV-positive patients had complete eradication of HPV after treatment. There were no serious adverse events after light exposure. Marked therapeutic response, high anti-viral activity and good feasibility allow to consider photodynamic therapy as alternative organ-sparing treatment of early cancer and pre-cancer of cervix.Β ΠΠΏΠΈΡΠ°Π½ ΠΎΠΏΡΡ Π»Π΅ΡΠ΅Π½ΠΈΡ ΠΏΡΠ΅Π΄ΡΠ°ΠΊΠ° ΠΈ ΡΠ°Π½Π½Π΅Π³ΠΎ ΡΠ°ΠΊΠ° ΡΠ΅ΠΉΠΊΠΈ ΠΌΠ°ΡΠΊΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΡΠΎΡΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ Ρ 12 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠΊ Ρ Π΄ΠΈΠ°Π³Π½ΠΎΠ·ΠΎΠΌ CIN II-III ΠΈ cancer in situ. Π€ΠΎΡΠΎΡΠ΅Π½ΡΠΈΠ±ΠΈΠ»ΠΈΠ·Π°ΡΠΎΡ Ρ
Π»ΠΎΡΠΈΠ½ΠΎΠ²ΠΎΠ³ΠΎ ΡΡΠ΄Π° ΡΠΎΡΠΎΠ»ΠΎΠ½ Π²Π²ΠΎΠ΄ΠΈΠ»ΠΈ Π²Π½ΡΡΡΠΈΠ²Π΅Π½Π½ΠΎ Π² Π΄ΠΎΠ·Π΅ 0,75β1,15 ΠΌΠ³/ΠΊΠ³ ΠΌΠ°ΡΡΡ ΡΠ΅Π»Π° ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΊΠΈ. Π§Π΅ΡΠ΅Π· 1,5β2 Ρ Π²ΡΠΏΠΎΠ»Π½ΡΠ»ΠΈ ΡΠ΅Π°Π½Ρ ΠΎΠ±Π»ΡΡΠ΅Π½ΠΈΡ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΏΠΎΠ»ΠΈΠΏΠΎΠ·ΠΈΡΠΈΠΎΠ½Π½ΠΎΠΉ ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΠΈ Π»Π°Π·Π΅ΡΠ½ΠΎΠ³ΠΎ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΡ (ΠΏΠ»ΠΎΡΠ½ΠΎΡΡΡ ΡΠ½Π΅ΡΠ³ΠΈΠΈ Π»Π°Π·Π΅ΡΠ½ΠΎΠ³ΠΎ ΠΈΠ·Π»ΡΡΠ΅Π½ΠΈΡ ΠΎΠ΄Π½ΠΎΠΉ ΠΏΠΎΠ·ΠΈΡΠΈΠΈ 150 ΠΠΆ/ΡΠΌ2, ΠΏΠ»ΠΎΡΠ½ΠΎΡΡΡ ΠΌΠΎΡΠ½ΠΎΡΡΠΈ 400β500 ΠΌΠΡ/ΡΠΌ2). Π§Π΅ΡΠ΅Π· 30 Π΄Π½Π΅ΠΉ ΠΏΠΎΡΠ»Π΅ Π»Π΅ΡΠ΅Π½ΠΈΡ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ ΠΊΠΎΠ½ΠΈΠ·Π°ΡΠΈΡ ΡΠ΅ΠΉΠΊΠΈ ΠΌΠ°ΡΠΊΠΈ Ρ Π²ΡΡΠΊΠ°Π±Π»ΠΈΠ²Π°Π½ΠΈΠ΅ΠΌ ΡΠ΅ΡΠ²ΠΈΠΊΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΊΠ°Π½Π°Π»Π°, ΠΎΡΠ΅Π½ΠΈΠ²Π°Ρ ΡΠ΅Π·ΡΠ»ΡΡΠ°Ρ ΡΠΎΡΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ. ΠΠΎ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ°ΠΌ Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΠΎΡΠ»Π΅ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π° ΡΡΡΠ΅ΠΊΡ Π»Π΅ΡΠ΅Π½ΠΈΡ Ρ 4 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠΊ ΠΎΡΠ΅Π½Π΅Π½ ΠΊΠ°ΠΊ ΠΏΠΎΠ»Π½Π°Ρ ΡΠ΅Π³ΡΠ΅ΡΡΠΈΡ, Ρ 7 ΠΏΠ°ΡΠΈ- Π΅Π½ΡΠΎΠΊ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½Ρ ΠΌΠ΅Π»ΠΊΠΈΠ΅ ΠΎΡΠ°Π³ΠΈ CIN I, Ρ 1 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΊΠΈ β ΠΎΡΠ°Π³ΠΈ CIN II. Π£ 8 ΠΈΠ· 10 ΠΠΠ§-ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΡΡ
ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠΊ ΠΏΠΎΡΠ»Π΅ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ Π»Π΅ΡΠ΅Π½ΠΈΡ Π±ΡΠ»Π° ΠΏΠΎΠ»ΡΡΠ΅Π½Π° ΠΏΠΎΠ»Π½Π°Ρ ΡΡΠ°Π΄ΠΈΠΊΠ°ΡΠΈΡ ΠΠΠ§. ΠΡΠΈ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠΈ ΠΏΡΠΎΡΠ΅Π΄ΡΡΡ ΠΎΠ±Π»ΡΡΠ΅Π½ΠΈΡ Π½Π΅ Π±ΡΠ»ΠΎ Π·Π°ΡΠ΅Π³ΠΈΡΡΡΠΈΡΠΎΠ²Π°Π½ΠΎ ΡΠ΅ΡΡΠ΅Π·Π½ΡΡ
Π½Π΅ΠΆΠ΅Π»Π°ΡΠ΅Π»ΡΠ½ΡΡ
ΡΠ²Π»Π΅Π½ΠΈΠΉ. ΠΡΡΠ°ΠΆΠ΅Π½Π½ΡΠΉ ΡΠ΅ΡΠ°ΠΏΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΡΡΠ΅ΠΊΡ, Π²ΡΡΠΎΠΊΠ°Ρ ΠΏΡΠΎΡΠΈΠ²ΠΎΠ²ΠΈΡΡΡΠ½Π°Ρ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΈ Ρ
ΠΎΡΠΎΡΠ°Ρ ΠΏΠ΅ΡΠ΅Π½ΠΎΡΠΈΠΌΠΎΡΡΡ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡΡ ΡΠ°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°ΡΡ ΡΠΎΡΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΡΡ ΡΠ΅ΡΠ°ΠΏΠΈΡ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ Π°Π»ΡΡΠ΅ΡΠ½Π°ΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΎΡΠ³Π°Π½ΠΎΡΠΎΡ
ΡΠ°Π½ΡΡΡΠ΅Π³ΠΎ Π»Π΅ΡΠ΅Π½ΠΈΡ ΡΠ°Π½Π½Π΅Π³ΠΎ ΡΠ°ΠΊΠ° ΠΈ ΠΏΡΠ΅Π΄ΡΠ°ΠΊΠ° ΡΠ΅ΠΉΠΊΠΈ ΠΌΠ°ΡΠΊΠΈ.
Photodynamic therapy for cervical lesions
The experience of treatment for precancer and early cervical cancer by photodynamic therapy in 12 patients with primary diagnosis H-SIL (CIN IIβIII) and cancer in situ is described. Chlo-rine photosensitizer Photolon was given intravenously at a dose of 0.75β1.15 mg/kg body weight. 2.5 h later the treatment with polyposition laser exposure (light dose β 150 J/cm2, light power density β 400β500 mW/cm2) was made. Thirty days later conization of the cervix with endocervical curettage assessing therapeutic response of cervical tumor tissue was per-formed. According to histological data complete response was in 4 patients, minute foci of CIN I were determined in 7 patients, 1 patient had foci of CIN II. 8 of 10 HPV-positive patients had complete eradication of HPV after treatment. There were no serious adverse events after light exposure. Marked therapeutic response, high anti-viral activity and good feasibility allow to consider photodynamic therapy as alternative organ-sparing treatment of early cancer and pre-cancer of cervix.Β </p