PCNA Retention on DNA into G2/M Phase Causes Genome Instability in Cells Lacking Elg1

Acknowledgments We thank Richard Kolodner, Grant Brown, and Daniel Durocher for strains and plasmids. We thank Anne Donaldson, Alexander Lorenz, and Shin-ichiro Hiraga from University of Aberdeen for careful reading of the manuscript. Research in T.K.’s lab is supported by Medical Research Council Career Development Fellowship L019698/1. V.K.G. was supported by Biotechnology and Biological Sciences Research Council grant K006304/1. T.S.T. was supported by grants from the Ministry of Education, Culture, Sports, Science and Technology of Japan (nos. 23131507 and 25131712).Peer reviewedPublisher PD

Polarization mode dispersion in radio-frequency interferometric embedded fiber-optic sensors

The effect of fiber birefringence on the propagation delay in an embedded fiber-optic strain sensor is studied. The polarization characteristics of the sensor are described in terms of polarization mode dispersion through the principal states of polarization and their differential group delay. Using these descriptors, an analytical expression for the response of the sensor for an arbitrary input state of polarization is given and experimentally verified. It is found that the differential group delay, as well as the input and output principal states of polarization, vary when the embedded fiber is strained, leading to fluctuations in the sensor output. The use of high birefringence fibers and different embedding geometries is examined as a means for reducing the polarization dependency of the sensor

Investigation of Fiber Reinforced Cementitious Matrix Composite Wrapped Stack Bonded Brick Masonry under Compressive Load

Masonry construction is the most ancient construction practice that is still in use in the modern era. Some of the existing masonry structures have survived for several hundreds of years. Most of the existing masonry structures were built using available knowledge or as per the available codes of practice. With passage of time these masonry structures are in need of restoration and strengthening as many of the structures have become part of cultural heritage with a high social value Brick masonry is composite material composed of two materials with different properties: stiffer clay bricks and relatively softer mortar. In structural applications, brick masonry is used primarily as a compression carrying member. Under compression, the resulting shear stresses at the brick-mortar interface produce an internal state of stress which consists of tri-axial compression in mortar and biaxial tension coupled with axial compression in bricks. A clear understanding of the strains in brick and mortar at different stages of loading and their relation to the uniaxial response of masonry is not currently available. Proper understanding of the stress states in individual material properties and failure in compression of masonry will lead to improvements in Engineering and design practices

Power Control of Grid Connected Doubly Fed Induction Generator with Sensor-less Speed and Position Estimation Algorithm

The aim of this thesis deals with the analysis, modeling and control of doubly-fed induction generator (DFIG) for wind turbines. The system uses two converters connected back to back, one is rotor side converter (RSC) or machine side converter and the other one is front end converter or grid side converter (GSC). The rotor side converter controls the active and reactive power by controlling the d-q components of rotor current (i.e

Single-photon emitting diode in silicon carbide

Electrically driven single-photon emitting devices have immediate applications in quantum cryptography, quantum computation and single-photon metrology. Mature device fabrication protocols and the recent observations of single defect systems with quantum functionalities make silicon carbide (SiC) an ideal material to build such devices. Here, we demonstrate the fabrication of bright single photon emitting diodes. The electrically driven emitters display fully polarized output, superior photon statistics (with a count rate of $>$300 kHz), and stability in both continuous and pulsed modes, all at room temperature. The atomic origin of the single photon source is proposed. These results provide a foundation for the large scale integration of single photon sources into a broad range of applications, such as quantum cryptography or linear optics quantum computing.Comment: Main: 10 pages, 6 figures. Supplementary Information: 6 pages, 6 figure

Integration of Tobacco Treatment Services into Cancer Care at Stanford.

As part of a National Cancer Institute Moonshot P30 Supplement, the Stanford Cancer Center piloted and integrated tobacco treatment into cancer care. This quality improvement (QI) project reports on the process from initial pilot to adoption within 14 clinics. The Head and Neck Oncology Clinic was engaged first in January 2019 as a pilot site given staff receptivity, elevated smoking prevalence, and a high tobacco screening rate (95%) yet low levels of tobacco cessation treatment referrals (<10%) and patient engagement (<1% of smokers treated). To improve referrals and engagement, system changes included an automated "opt-out" referral process and provision of tobacco cessation treatment as a covered benefit with flexible delivery options that included phone and telemedicine. Screening rates increased to 99%, referrals to 100%, 74% of patients were reached by counselors, and 33% of those reached engaged in treatment. Patient-reported abstinence from all tobacco products at 6-month follow-up is 20%. In July 2019, two additional oncology clinics were added. In December 2019, less than one year from initiating the QI pilot, with demonstrated feasibility, acceptability, and efficacy, the tobacco treatment services were integrated into 14 clinics at Stanford Cancer Center

Effects of low energy electron irradiation on formation of nitrogen-vacancy centers in single-crystal diamond

Exposure to beams of low energy electrons (2 to 30 keV) in a scanning electron microscope locally induces formation of NV-centers without thermal annealing in diamonds that have been implanted with nitrogen ions. We find that non-thermal, electron beam induced NV-formation is about four times less efficient than thermal annealing. But NV-center formation in a consecutive thermal annealing step (800C) following exposure to low energy electrons increases by a factor of up to 1.8 compared to thermal annealing alone. These observations point to reconstruction of nitrogen-vacancy complexes induced by electronic excitations from low energy electrons as an NV-center formation mechanism and identify local electronic excitations as a means for spatially controlled room-temperature NV-center formation

Predictors of under Five Years Old Diarrhoeal Disease in Mataniko Informal Settlements in Solomon Islands

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