189 research outputs found
Kinetic equations for ultrarelativistic particles in a Robertson-Walker Universe and isotropization of relict radiation by gravitational interactions
Kinetic equations for ultrarelativistic particles with due account of
gravitational interactions with massive particles in the Robertson-Walker
universe are obtained. On the basis of an exact solution of the kinetic
equations thus obtained, a conclusion is made as to the high degree of the
uniformity of the relict radiation on scales with are less than .Comment: 19 pages, 2 figures, 13 reference
Classical and quantized aspects of dynamics in five dimensional relativity
A null path in 5D can appear as a timelike path in 4D, and for a certain
gauge in 5D the motion of a massive particle in 4D obeys the usual quantization
rule with an uncertainty-type relation. Generalizations of this result are
discussed in regard to induced-matter and membrane theory.Comment: 26 pages, in press in Class. Quant. Gra
Superior Neuroprotective Efficacy of LAU-0901, a Novel Platelet-Activating Factor Antagonist, in Experimental Stroke
Platelet-activating factor (PAF) accumulates during cerebral ischemia, and inhibition of this process plays a critical role in neuronal survival. Recently, we demonstrated that LAU-0901, a novel PAF receptor antagonist, is neuroprotective in experimental stroke. We used magnetic resonance imaging in conjunction with behavior and immunohistopathology to expand our understanding of this novel therapeutic approach. Sprague–Dawley rats received 2 h middle cerebral artery occlusion (MCAo) and were treated with LAU-0901 (60 mg/kg) or vehicle 2 h from MCAo onset. Behavioral function, T2-weighted imaging (T2WI), and apparent diffusion coefficients were performed on days 1, 3, and 7 after MCAo. Infarct volume and number of GFAP, ED-1, and NeuN-positive cells were conducted on day 7. Behavioral deficit was significantly improved by LAU-0901 treatment compared to vehicle on days 1, 3, and 7. Total lesion volumes computed from T2WI were significantly reduced by LAU-0901 on days 1, 3, and 7 (by 83%, 90%, and 96%, respectively), which was consistent with decreased edema formation. Histopathology revealed that LAU-0901 treatment resulted in significant reduction of cortical and subcortical infarct volumes, attenuated microglial infiltration, and promoted astrocytic and neuronal survival. These findings suggest LAU-0901 is a promising neuroprotectant and provide the basis for future therapeutics in patients suffering ischemic stroke
Docosahexaenoic Acid Therapy of Experimental Ischemic Stroke
We examined the neuroprotective efficacy of docosahexaenoic acid (DHA), an omega-3 essential fatty acid family member, in acute ischemic stroke; studied the therapeutic window; and investigated whether DHA administration after an ischemic stroke is able to salvage the penumbra. In each series described below, SD rats underwent 2 h of middle cerebral artery occlusion (MCAo). In series 1, DHA or saline was administered i.v. at 3, 4, 5, or 6 h after stroke. In series 2, MRI was conducted on days 1, 3 and 7. In series 3, DHA or saline was administered at 3 h, and lipidomic analysis was conducted on day 3. Treatment with DHA significantly improved behavior and reduced total infarct volume by a mean of 40% when administered at 3 h, by 66% at 4 h, and by 59% at 5 h. Total lesion volumes computed from T2-weighted images were reduced in the DHA group at all time points. Lipidomic analysis showed that DHA treatment potentiates neuroprotectin D1 (NPD1) synthesis in the penumbra 3 days after MCAo. DHA administration provides neurobehavioral recovery, reduces brain infarction and edema, and activates NPD1 synthesis in the penumbra when administered up to 5 h after focal cerebral ischemia in rats
Form factors for decay in a model constrained by chiral symmetry and quark model
The form factors for the transition are evaluated in the entire
momentum transfer range by using the constraints obtained in the framework
combining the heavy quark expansion and chiral symmetry for light quarks and
the quark model. In particular, we calculate the valence quark contributions
and show that it together with the equal time commutator contribution simulate
a B-meson pole q^2-dependence of form factors in addition to the usual vector
meson B^{*}-pole diagram for in the above framework. We
discuss the predictions in our model, which provide an estimate of |V_{ub}|^2.Comment: 7 pages, Revtex, 5 figure, fig 3 is replaced and some text is adde
Role of Vector Mesons in High-Q^2 Lepton-Nucleon Scattering
The possible role played by vector mesons in inclusive deep inelastic
lepton-nucleon scattering is investigated. In the context of the convolution
model, we calculate self-consistently the scaling contribution to the nucleon
structure function using the formalism of time-ordered perturbation theory in
the infinite momentum frame. Our results indicate potentially significant
effects only when the vector meson---nucleon form factor is very hard.
Agreement with the experimental antiquark distributions, however, requires
relatively soft form factors for the , and vertices.Comment: 22 pages, 9 figures (available upon request); accepted for
publication in Phys.Rev.D, ADP-92-197/T12
The Pioneer anomaly in the context of the braneworld scenario
We examine the Pioneer anomaly - a reported anomalous acceleration affecting
the Pioneer 10/11, Galileo and Ulysses spacecrafts - in the context of a
braneworld scenario. We show that effects due to the radion field cannot
account for the anomaly, but that a scalar field with an appropriate potential
is able to explain the phenomena. Implications and features of our solution are
analyzed.Comment: Final version to appear at Classical & Quantum Gravity. Plainlatex 19
page
Microvessel changes after post-ischemic benign and malignant hyperemia: experimental study in rats
<p>Abstract</p> <p>Background</p> <p>The present investigation was designed to elucidate the use of dynamic contrast enhanced perfusion MR imaging (DCE pMRI) in characterizing hyperemia, including microvessel changes, and to examine whether DCE pMRI can predict benign or malignant hyperemia.</p> <p>Methods</p> <p>Sprague-Dawley rats underwent middle cerebral artery occlusion (MCAO) by intraluminal suture placement. All rats were randomized to 4 groups: MCAO for 0.5 hours followed by saline treatment (10 ml/kg; group 1); MCAO for 3 hours followed by treatment with saline (group 2) or urokinase (25000 IU/kg; group 3); and MCAO for 6 hours followed by urokinase treatment (group 4). Relative cerebral blood volume (rCBV) and relative maximum slope of increase of the signal intensity time curve (rMSI) were quantitatively analyzed from MRI. Microvessel diameter and blood-brain barrier disruption obtained by laser scanning confocal microscopy (LSCM) as well as transmission electron microscopy (TEM) were obtained for correlative study.</p> <p>Results</p> <p>Benign hyperemia was noticed only in group 1; malignant hyperemia was seen in group 3. Although the rCBV of malignant hyperemia was slightly higher than in benign hyperemia (<it>P </it>> 0.05), the rMSI, on the other hand, was significantly lower (<it>P </it>< 0.05). Fluoro-isothiocyanate dextran (FITC-dextran) extravasations, marked glial end-foot process swelling, and significant vasodilatation were seen in malignant hyperemia, while no or mild leakage of FITC-dextran and slight glial end-foot process swelling occurred in benign hyperemia.</p> <p>Conclusion</p> <p>Our findings indicate that DCE pMRI can characterize post-ischemic hyperemia and correlates well with microvascular damage.</p
Probing exotic phenomena at the interface of nuclear and particle physics with the electric dipole moments of diamagnetic atoms: A unique window to hadronic and semi-leptonic CP violation
The current status of electric dipole moments of diamagnetic atoms which
involves the synergy between atomic experiments and three different theoretical
areas -- particle, nuclear and atomic is reviewed. Various models of particle
physics that predict CP violation, which is necessary for the existence of such
electric dipole moments, are presented. These include the standard model of
particle physics and various extensions of it. Effective hadron level combined
charge conjugation (C) and parity (P) symmetry violating interactions are
derived taking into consideration different ways in which a nucleon interacts
with other nucleons as well as with electrons. Nuclear structure calculations
of the CP-odd nuclear Schiff moment are discussed using the shell model and
other theoretical approaches. Results of the calculations of atomic electric
dipole moments due to the interaction of the nuclear Schiff moment with the
electrons and the P and time-reversal (T) symmetry violating
tensor-pseudotensor electron-nucleus are elucidated using different
relativistic many-body theories. The principles of the measurement of the
electric dipole moments of diamagnetic atoms are outlined. Upper limits for the
nuclear Schiff moment and tensor-pseudotensor coupling constant are obtained
combining the results of atomic experiments and relativistic many-body
theories. The coefficients for the different sources of CP violation have been
estimated at the elementary particle level for all the diamagnetic atoms of
current experimental interest and their implications for physics beyond the
standard model is discussed. Possible improvements of the current results of
the measurements as well as quantum chromodynamics, nuclear and atomic
calculations are suggested.Comment: 46 pages, 19 tables and 16 figures. A review article accepted for
EPJ
In vivo PET imaging of the neuroinflammatory response in rat spinal cord injury using the TSPO tracer [F-18]GE-180 and effect of docosahexaenoic acid
Centre for Trauma Sciences, funded by the Barts & The London Charity, GE Healthcare Ltd, the
Experimental Medicine Awards from the Blizard Institute and the Imaging Centre at the Barts Cancer Institute
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