New <i>N</i>-Linked Phosphonamidate Derivatives of 6-Chloropurine: Synthesis and Evaluation of Antimicrobial and Antioxidant Activities

<div><p>GRAPHICAL ABSTRACT</p><p></p></div

Synthesis, spectral characterization and bioactivity evaluation of novel α-aminophosphonates

<p>A facile synthesis of novel α-aminophosphonates <b>5a-j</b> was accomplished by condensation of imines (<b>3a-j)</b> with diethyl phosphite (<b>4</b>) in ethanol at 50–60°C using easily recoverable and reusable catalyst, tetramethyl guanidine (TMG) via pudovik reaction in high yields. All the title compounds were characterized by spectral and elemental analysis. They were further screened for their abilities towards <i>in vitro</i> antibacterial, antifungal and antioxidant activities. The compounds <b>5g</b>, <b>5d, 5f</b> exhibited good antibacterial and antifungal activities compared to the standard bactericide, Penicillin and fungicide, Griseofulvin, respectively. The compounds <b>5h</b>, <b>5i</b>, <b>5g</b>, and <b>5c</b> exhibited good antioxidant activity compared to the standard ascorbic acid.</p