New physics solutions for RDR_D and RD∗R_{D^*}

Recent measurements of $R_{D^*}$ have reduced tension with the Standard Model prediction. Taking all the present data into account, we obtain the values of the Wilson coefficients of each new physics four-fermion operator of a given Lorentz structure. We find that the combined data rule out most of the solutions based on scalar/pseudoscalar operators. By studying the inter-relations between different solutions, we find that there are only four allowed solutions, which are based on operators with $(V-A)$, linear combination of $(V-A)$ and $(V+A)$, tensor and linear combination of scalar/pseudoscalar and tensor structure. We demonstrate that the need for new physics is driven by those measurement of $R_D$ and $R_{D^*}$ where the $\tau$ lepton is not studied. Further, we show that new physics only in $b\rightarrow c\,\mu\,\bar{\nu}$ is not compatible with the full set of observables in the decays $B\rightarrow Dl\bar{\nu}$ and $B\rightarrow D^*l\bar{\nu}$.Comment: 16 pages, 1 figure (Accepted for publication in JHEP

Social costs and benefits of micro irrigation system adoption in canal commands: a study from IGNP command area of Bikaner in Rajasthan

Irrigation systemsDrip irrigationSprinkler irrigationCrop productionWater productivityLivestockCost benefit analysis

Gene expression strategies of barley yellow dwarf virus

Barley yellow dwarf virus (BYDV) has a positive sense, 5.7kb RNA genome encoding at least six open reading frames (ORFs). BYDV uses variety of unusual translational strategies to express its genes. These include frameshifting in the polymerase (60K) ORF, leaky scanning at the AUGs of the overlapping coat protein (CP) and 17K ORFs, and readthrough of the CP stop codon;Full-length cDNA clone of BYDV-PAV has been constructed to understand functions of different viral genes and the roles of specific sequences in translation, replication and encapsidation. Translation in cell-free extracts using in vitro synthesized full-length transcripts resulted in expected 99 kDa frameshift product. These transcripts were biologically active. The 39K ORF at the 5\u27 end of the genome overlaps by 13 nucleotides with a 60K ORF. The region of overlap contains a shifty heptanucleotide, followed by a highly structured region that may contain a pseudoknot. The 39K ORF stop codon immediately next to the shifty heptanucleotide sequence is necessary for in vivo frameshifting and viral replication. Deletion mutants indicate that the ORF1, ORF2 and ORF6 or 3[superscript]\u27 terminal 1157 nucleotides are necessary for BYDV-PAV replication in protoplasts;The CP, 17K and 50K ORFs located at the 3\u27 half of the genome are expressed from a tricistronic subgenomic RNA (sgRNA1), that is generated in infected cells. The 17K ORF is embedded in the sequence that encodes the CP ORF, in a different reading frame. The 17K ORF start codon is 43 bases downstream of the CP start codon. Ribosomes initiate translation at the start codons of both ORFs, giving rise to both proteins. Systematic mutagenesis was performed to show, in vitro and in vivo, that overlapping ORFs of the sgRNA1 are expressed by Kozak\u27s leaky scanning mechanisms. A new ribosome pausing model is proposed to explain the unexpected observation that mutations that reduce translation initiation at the downstream 17K AUG also reduce initiation at the upstream CP AUG. Implications of these results on expression of luteovirus coat protein in transgenic plants are discussed;The 50K ORF is translated by readthrough of the CP stop codon, giving rise to 72 kDa polypeptide in vitro. The GUS reporter gene was inserted downstream of the CP stop codon in the full-length BYDV-PAV infectious clone to elucidate the mechanism of readthrough for the luteovirus class. Results indicate that the signals required in luteovirus class are more complex and different from the well-studied tobacco mosaic virus like group of readthrough. Use of readthrough strategy to express biologically active recombinant proteins are discussed

Wells and ill-fare: impacts of well failures on cultivators in hard rock areas of Madhya Pradesh

WellsDrillingCostsGroundwater depletionWater tableGroundwater irrigationOwnershipEconomic impactSocial impactCrop managementFood security

Risk analaysis of ethanol blending fuel in refinery industry using event tree analysis and Topsis method

Chemicals have always posed risks including fire, explosion, and the release of harmful substances in process industries like the Petroleum Industry. The occurrence of such catastrophes has a significant impact on the resources for finances and daily living. In this research paper, the major safety-related causes and effects are identified through event tree analysis based on accidents and incidents while using ethanol as fuel. For this purpose, the accident and incident data collected so far while using ethanol in the fuel industry, detailed information about ethanol, and even tree analysis. The event tree analysis (ETA) and Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) analysis method is utilized to Identifying an initiating event of interest of accident. The event tree\u27s structure also aids the analyst in identifying the locations where additional protocols or safety measures are required to mitigate accidents or lower their frequency