Anemia in experimental protein deficiency in the rhesus monkey with special reference to iron metabolism

1. This investigation deals with a study of the anemia of protein deficiency in Rhesus monkeys. 2. Protein deficiency was induced in 17 rhesus monkeys. Seven animals, given a protein-rich diet, served as controls. The diets of both the groups were identical in all respects, except protein. All animals were tube-fed to ensure adequate caloric intake. Hematocrit, hemoglobin, erythroctye count, serum iron, serum iron binding capacity, plasma iron tolerance curves, and iron absorption using the Fe59 fecal recovery method were studied before and at intervals of the experiment in both deficient and control groups. Protein-deficient monkeys consistently developed normocytic normochromic anemia of moderate severity. A striking fall in serum iron binding capacity, total proteins and albumin with a rise in gamma globulin was observed in all deficient animals. A significant and comparable fall in serum iron was also observed. The Fe59 absorption was depressed and there was flattening of plasma iron tolerance curves. Two deficient animals, refed a high protein diet, showed reversal of all these changes. The control animals did not show any of these changes. The mechanism of anemia and decreased iron absorption observed in the protein-deficient animals and the relevance of these findings to those in Kwashiorkor are discussed

An intensive audit on 250 patients of advanced ovarian cancer to improve quality of care in a tertiary referral oncology centre in India

Background: A clinical audit provides the framework to improve the quality of patient care in a systematic way. In this study, we intensively audited our 250 advanced epithelial ovarian cancer (EOC) patients aiming to improve our patient care.Methods: Ambispective study of 250 patients of advanced EOC was done from our prospectively maintained computerized database in the department of surgical oncology, AIIMS, New Delhi from 2013 to 2020.We audited the demographic profile, treatment patterns, perioperative and survival outcomes in different subgroups.Results: In this study, 83.6% stage III and 16.4% stage IV A. There was 62 (24.8%) upfront, 112 (44.8%) interval and 76 (30.4%) secondary group. 126 underwent cytoreductive surgery (CRS) and 124 CRS and hyperthermic intraperitoneal chemotherapy (HIPEC). There was 24.8% early and 8.4% late postop complications. Median follow up 50 months. Overall, the median disease-free survival (DFS) 39 months. PFS was 12 months among 68 patients with recurrence. Attrition rate 4%. In the upfront setting, the median DFS 44 months in CRS only group and DFS not reached (p=0.032) in CRS and HIPEC group still. In the interval setting, the median DFS 39 months in CRS only group and 44 months in CRS and HIPEC group (p=0.06). In recurrent setting, the median DFS 14 months in CRS group and 23 months in CRS and HIPEC group (p=0.02)Conclusions: Audit is an integral part of any clinical practice. It teaches us to improve the quality of care and thereby better outcomes. We recommend 6 monthly clinical audits in any cancer treatment for better outcomes in future

Metastability and paramagnetism in superconducting mesoscopic disks

A projected order parameter is used to calculate, not only local minima of the Ginzburg-Landau energy functional, but also saddle points or energy barriers responsible for the metastabilities observed in superconducting mesoscopic disks (Geim et al. Nature {\bf 396}, 144 (1998)). We calculate the local minima magnetization and find the energetic instability points between vortex configurations with different vorticity. We also find that, for any vorticity, the supercurrent can reverse its flow direction on decreasing the magnetic field before one vortex can escape.Comment: Modified version as to appear in Phys. Rev. Let

Hysteresis in mesoscopic superconducting disks: the Bean-Livingston barrier

The magnetization behavior of mesoscopic superconducting disks can show hysteretic behavior which we explain by using the Ginzburg-Landau (GL) theory and properly taking into account the de-magnetization effects due to geometrical form factors. In large disks the Bean-Livingston surface barrier is responsible for the hysteresis. While in small disks a volume barrier is responsible for this hysteresis. It is shown that although the sample magnetization is diamagnetic (negative), the measured magnetization can be positive at certain fields as observed experimentally, which is a consequence of the de-magnetization effects and the experimental set up.Comment: Latex file, 4 ps file

Effect of gas flow on electronic transport in a DNA-decorated carbon nanotube

We calculate the two-time current correlation function using the experimental data of the current-time characteristics of the Gas-DNA-decorated carbon nanotube field effect transistor. The pattern of the correlation function is a measure of the sensitivity and selectivity of the sensors and suggest that these gas flow sensors may also be used as DNA sequence detectors. The system is modelled by a one-dimensional tight-binding Hamiltonian and we present analytical calculations of quantum electronic transport for the system using the time-dependent nonequilibrium Green's function formalism and the adiabatic expansion. The zeroth and first order contributions to the current $I^{(0)}(\bar{t})$ and $I^{(1)}(\bar{t})$ are calculated, where $I^{(0)} (\bar{t})$ is the Landauer formula. The formula for the time-dependent current is then used to compare the theoretical results with the experiment.Comment: 14 pages, 5 figures and 2 table

USE OF HIGH VOLUME FLY ASH ON EARLY AGE SHRINKAGE IN CONCRETE FOR LOCAL HOT AND DRY CONDITION

Recently contractors are demanding a reliable and all-weather partial or full replacement material for sand due to government restrictions on natural sand mining from river beds. Many previous studies showed that fly ash as a pozzolanic material is effective for improving the various properties of concrete. Advantages of fly ash as partial replacement of cement in concrete on early age shrinkage are reported in standard literature. However, effect of fly ash as partial replacement of cement and sand in concrete on early age shrinkage is not clearly available in reputed literature. This paper discusses the experimental research carried out on early age shrinkage of concrete mixtures in which cement and sand were partially replaced with high volume class F fly ash. Nine mixes were prepared that is C0-0, C20-0, C40-0, C0-20, C0-40, C20-20, C20- 40, C40-20 & C40-40 by partly replacing cement and sand by fly ash and compared with control concrete at an early age by using shrinkage cone apparatus. Combine replacement up to 40% of cement and 20% sand by fly ash respectively gives the better result than other mixes. Combine replacement 40% cement and 40% sand by fly ash has reduced the shrinkage by 63.13% than the control mix. In general, incorporation of fly ash as a partial replacement of cement and sand reduced the shrinkage properties and adds sustainability to concrete by reducing CO2 emission during cement production

Manejo da mancha angular (Xanthomonas campestris pv. Mangiferae indica) na produção integrada de manga.

bitstream/CPATSA/33055/1/INT63.pd

Temperature enhanced persistent currents and "ϕ0/2\phi_0/2 periodicity"

We predict a non-monotonous temperature dependence of the persistent currents in a ballistic ring coupled strongly to a stub in the grand canonical as well as in the canonical case. We also show that such a non-monotonous temperature dependence can naturally lead to a $\phi_0/2$ periodicity of the persistent currents, where $\phi_0$=h/e. There is a crossover temperature $T^*$, below which persistent currents increase in amplitude with temperature while they decrease above this temperature. This is in contrast to persistent currents in rings being monotonously affected by temperature. $T^*$ is parameter-dependent but of the order of $\Delta_u/\pi^2k_B$, where $\Delta_u$ is the level spacing of the isolated ring. For the grand-canonical case $T^*$ is half of that for the canonical case.Comment: some typos correcte

On subgroups in division rings of type 22

Let $D$ be a division ring with center $F$. We say that $D$ is a {\em division ring of type $2$} if for every two elements $x, y\in D,$ the division subring $F(x, y)$ is a finite dimensional vector space over $F$. In this paper we investigate multiplicative subgroups in such a ring.Comment: 10 pages, 0 figure

Vortex phase diagram for mesoscopic superconducting disks

Solving numerically the 3D non linear Ginzburg-Landau (GL) equations, we study equilibrium and nonequilibrium phase transitions between different superconducting states of mesoscopic disks which are thinner than the coherence length and the penetration depth. We have found a smooth transition from a multi-vortex superconducting state to a giant vortex state with increasing both the disk thickness and the magnetic field. A vortex phase diagram is obtained which shows, as function of the magnetic field, a re-entrant behavior between the multi-vortex and the giant vortex state.Comment: 5 figures (post script files) include