34 research outputs found
The Puromycin Route to Assess Stereo- and Regiochemical Constraints on Peptide Bond Formation in Eukaryotic Ribosomes
Get PDFWe synthesized a series of puromycin analogues to probe the chemical specificity of the ribosome in an intact eukaryotic translation system. These studies reveal that both d-enantiomers and β-amino acid analogues can be incorporated into protein, and provide a quantitative means to rank natural and unnatural residues. Modeling of a d-amino acid analogue into the 50S ribosomal subunit indicates that steric clash may provide part of the chiral discrimination. The data presented provide one metric of the chiral and regiospecificity of mammalian ribosomes
The Puromycin Route to Assess Stereo- and Regiochemical Constraints on Peptide Bond Formation in Eukaryotic Ribosomes
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Wide prevalence of hybridization in two sympatric grasshopper species may be shaped by their relative abundances
Full text linkOligonucleotidic compounds. VIII. Synthesis of adenylyl-(5'→3')-uridine, adenylyl-(5'→3')-cytidine, guanylyl-(5'→3')-uridine, guanylyl(5'→3')-cytidine, cytidylyl-(5'→3')-cytidine, adenylyl-(5'→3')-uridylyl-(5'→3')-cytidine and related compounds
No full textOligonucleotidic compounds. XIII. 2'-O-(1-Ethoxyethyl)-5'-O-acetylderivatives of uridine 3'-phosphate and N-acetylcytidine 3'-phosphate
No full textAminoacyl derivatives of nucleosides, nucleotides and polynucleotides. I. Synthesis of 2'(3')-O-glycyl ribonucleosides and ribonucleoside 5'-phosphates via intermediates of the orthoester type
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