34 research outputs found
Effects of a single cleavage in insulin-like growth factors I and II on binding to receptors, carrier proteins and antibodies
Preclinical and Clinical In Vitro In Vivo Correlation of an hGH Dextran Microsphere Formulation
Potentiation of tumour apoptosis by human growth hormone via glutathione production and decreased NF-κB activity
Changes in serum somatomedin and growth hormone concentrations after 3 weeks oestrogen substitution in post-menopausal women; a pilot study
Oestrogens have a preventive effect on bone loss in post-menopausal women; however, little is known about their mechanism of action. The aim of this study was to investigate the changes in somatomedins (SM) and growth hormone (GH) concentrations in serum in post-menopausal women after 3 weeks of substitution with 20 micrograms ethinyloestradiol. A significant decrease was observed in the mean serum levels of SM, measured by bioassay (0.66 +/- 0.07 vs 0.38 +/- 0.07, P less than 0.01), radioimmunoassay (0.62 +/- 0.08 vs 0.34 +/- 0.03, P less than 0.01) and radioreceptorassay (1.14 +/- 0.11 vs 0.90 +/- 0.09, P less than 0.01). The mean serum GH concentration increased (9.4 +/- 3.2 vs 16.5 +/- 4.6, P less than 0.01). A positive role of SM and GH in the changes of bone metabolism after oestrogen substitution in post-menopausal women is discusse