FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLET OF AMLODIPINE BESYLATE

Objective: The main objective of this research work was to formulate and evaluate the mouth dissolving tablet of amlodipine besylate for the treatment of hypertension and coronary artery disease. Methods: In this study, mouth dissolving tablet were prepared by direct compression method by using croscarmellose sodium and sodium starch glycolate as superdisintegrants. The designed tablets were subjected to various assessment parameters like friability test, hardness test, disintegration test, wetting time, in vitro drug release and drug content. Results: All the prepared formulations were subjected to various assessment parameters, and the findings obtain within the prescribed limit. The calibration curve of pure drug using various solvents like phosphate buffer pH 6.8, methanol was plotted. F1-F9 containing croscarmellose sodium and sodium starch glycolate in various concentration demonstrate the minimum disintegration time. Among all these formulations F9 shows disintegration time up to 22±1.12 seconds due to the high concentration of superdisintegrants. In vitro drug release was tested in phosphate buffer pH 6.8 at a time interval of 0, 1, 2, 3, 4, 5 min. The F9 shows drug release 100.22±1.08%. Accelerated stability study of optimized formulation (F9) up to 2 mo showed there was no change in disintegration time and percentage drug release. Conclusion: The results obtained in the research work clearly showed a promising potential of mouth dissolving tablets containing a specific ratio of croscarmellose sodium and sodium starch glycolate as superdisintegrants for the effective treatment of hypertension and coronary artery disease

Threshold meson production and cosmic ray transport

An interesting accident of nature is that the peak of the cosmic ray spectrum, for both protons and heavier nuclei, occurs near the pion production threshold. The Boltzmann transport equation contains a term which is the cosmic ray flux multiplied by the cross section. Therefore when considering pion and kaon production from proton-proton reactions, small cross sections at low energy can be as important as larger cross sections at higher energy. This is also true for subthreshold kaon production in nuclear collisions, but not for subthreshold pion production.Comment: 9 pages, 1 figur

Excitation functions of proton-induced reactions on

Excitation functions of proton-induced reactions for the natural iron and zirconium targets were measured from their respective threshold energies to 22 and 20 MeV. The conventional stacked foil technique was used in combination with the off-line $\gamma$-ray spectroscopy at the BARC-TIFR Pelletron facility, Mumbai. The computer code SRIM 2013 was used to calculate the energy degradation along the stack and the proton beam intensity was measured via the natCu(p,x)62Zn monitor reaction. The measured excitation functions were then compared with the literature data available in EXFOR database as well as with the theoretical values from the TALYS-1.8 code and the TENDL-2017 data library. The shapes of the excitation function for all the reactions were reproduced well by TALYS-1.8. In terms of absolute values, for some reactions the data are in good agreement with both the literature data and TALYS-1.8 whereas, for others there is a slight deviation either from the literature data or from the theoretical values of TALYS-1.8 and TENDL-2017

Measurement of

The $$^{96}\rm{Zr}(n,\gamma)^{97}Zr$$ reaction cross sections relative to $$^{197}\rm{Au}(n,\gamma)^{198}Au$$ monitor reaction with the neutron energies of 0.61 and 1.05 MeV from the 7Li(p,n)7Be reaction have been measured for the first time by using the activation and off-line $\gamma$-ray spectrometric technique. The error analysis of the experimental data was done by considering the partial uncertainties in various attributes and the correlations between those attributes were reported through covariance analysis. The present experimental cross sections have been compared with the theoretical prediction by TALYS-1.8 using the back-shifted Fermi gas model and Brink-Axel Lorentzian $\gamma$-ray strength functions. The TALYS-1.8 calculations well predicted the present experimental cross sections at both neutron energies. The spectrum averaged neutron capture cross sections of 96Zr obtained in the present work have also been compared with the evaluated cross sections from ENDF/B-VIII.0, JENDL-4, JEFF-3.3, CENDL-3.1 and TENDL-2015 libraries. They are found to be in close agreement with the TENDL-2015 and CENDL-3.1 libraries at the neutron energies of 0.61 and 1.05 MeV

Label-free quantitative proteomics of surgically isolated brain vessels from Alzheimer's mice to study the effect of Pioglitazone.

Peer reviewed: YesNRC publication: Ye