Gale hyperkératosique chez un patient âgé immunocompétent.

Introduction :La gale norvégienne est une forme de gale hyperkératosique extrêmement contagieuse liée à une infestation par des Sarcoptes scabiei var. hominis. Elle survient classiquement chez l’immunodéprimé.Observation :Nous rapportons un cas de gale norvégienne survenant chez un homme de 75 ans, sans antécédents particuliers, qui présentait depuis un an des lésions érythémateux-maculo-papuleuses évoluant vers la desquamation et étendu dans tous le corps en épargnant le visage et le cuir chevelu. Plusieurs diagnostic ont été évoqué à tort notamment le psoriasis. L'évolution était marquée par l'apparition de lésions croûteuses avec des squames hyperkératosiques. L’examen parasitologique direct, réalisé sur des lames préparées à partir de plusieurs prélèvements, obtenus par grattage des lésions cutanées, a mis en évidence de nombreux Sarcoptes scabiei et des galeries d’œufs, conduisant au diagnostic de la gale norvégienne. Après un traitement à base de benzoate de benzyle, le patient décédait dans un tableau de choc septique.Discussion et conclusion :La gale norvégienne devient de plus en plus rependue avec l’utilisation plus large des immunosuppresseurs. Son diagnostic est souvent porté tardivement et son traitement est difficile. Non traitée, l’infestation modifie le microbiote cutané et les surinfections sont fréquentes d’où l'importance d’un diagnostic précoce notamment chez le sujet âgé à fin d'éviter des complications potentiellement mortelles

Youth as Actors of Change? The Cases of Morocco and Tunisia

In the last decades, ‘youth’ has increasingly become a fashionable category in academic and development literature and a key development (or security) priority. However, beyond its biological attributes, youth is a socially constructed category and also one that tends to be featured in times of drastic social change. As the history of the category shows in both Morocco and Tunisia, youth can represent the wished-for model of future citizenry and a symbol of renovation, or its ‘not-yet-adult’ status which still requires guidance and protection can be used as a justification for increased social control and repression of broader social mobilisation. Furthermore, when used as a homogeneous and undifferentiated category, the reference to youth can divert attention away from other social divides such as class in highly unequal societies

Economic Evaluation of Information Security

Holtgrefe, A.A.I. [Promotor]Oosterhaven, J.A. [Promotor

Atherosclerosis and atherosensitivity in two southwest Algerian desert rodents, Psammomys obesus and Gerbillus gerbillus, and in Rattus norvegicus

Salima El-Aoufi,1 Mohamed-Amine Lazourgui,1 Lakhdar Griene,2 Boubekeur Maouche31Laboratoire de Biologie et de Physiologie des Organismes/MMDED, Faculté des Sciences Biologiques, USTHB, El-Alia, Dar El Beida, Algeria; 2Laboratoire d'Hormonologie, Centre Pierre et Marie Curie, C.H.U Mustapha, Algeria; 3Laboratoire de Physicochimie Théorique et Chimie Informatique, Faculté de Chimie, USTHB, El-Alia, Dar El Beida, AlgeriaAbstract: Cardiovascular disease, including atherosclerosis, is the leading cause of death in patients with diabetes worldwide; thus, it is a major medical concern. The endothelium contributes to the control of many vascular functions, and clinical observations show that it is a primary target for diabetic syndrome. To get better insight into the mechanisms underlying atherosclerosis, we studied the interspecific differences in the arterial metabolisms of two, Psammomys obesus and Gerbillus gerbillus, as well as Rattus norvegicus (Wistar rat), well known for its atheroresistance. Twenty-two enzymatic activities and six macromolecular substances were histochemically compared in the two desert species and in Wistar aortas (abdominal and thoracic) and arteries (femoral and caudal) embedded in a common block. In the healthy adult rodents, enzyme activities were very intense. They demonstrated that aortic myocytes are capable of various synthesis and catabolism processes. However, considering the frequency of atherosclerosis and its phenotypes, significant differences appeared between the species studied. Our comparative study shows that aortic atherosensitive animals have several common metabolic characteristics, which are found in Psammomys rich in metachromatic glycosaminoglycans (involved in the inhibition of lipolysis and in calcification of the organic matrix), reduced activity in enzymes related to the Krebs cycle (weakening energetic power), and low lipolytic enzyme, adenosine triphosphatase, and adenosine diphosphatase activities. However, the most fundamental pathophysiological difference is the low lipolytic power of the aorta of Psammomys when compared to Wistar rats. This characteristic determines its atherosensitivity and makes this animal model more applicable to the experimental development of atherosclerosis.Keywords: diet-induced diabetes, CVD, atherosensitivity, artery enzymatic activities, histochemistry, Psammomys obesu

3D modeling of unconstrained HPT process: role of strain gradient on high deformed microstructure formation

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