Possibility study of areas with potential cultivation of saffron in Kashmar plain using GIS

Saffron as the most expensive agriculture and medicinal product of world, is a plant in Consider to aridity resistant has interesting role in social and economical status of arid and semi arid of southern and Razavi Khorasan provinces. The aim of this paper, is determining the suitable area in Saffron cultivation with regards to effective factors. The climatic elements data were obtain from Khorasan Razavi Meteorological Organization for 1989-2012 periods. The topographic data including; relief, slope, aspect and TIN layers extracts from 1: 50000 topographic maps of the region. The land use and vegetation land cover maps were prepared using 1: 50000 maps of National soil and water Research Institute. The spatial analysis facilities of GIS were used for numerical calculation and drawing the requiring maps. A spatial geo database from region was established then spatial and description data entered on this database. Using by AHP software each layer weighted by its importance. Finally, by overlaying analysis in ArcGIS, cultivated area were classified by its capabilities .The results showed that Central and Southern Kashmar plain are the best capabilities for Saffron cultivation that in present statues, these lands specified to dry farming, irrigated farming, semi condense and condense rangelands

Biallelic PRMT7 pathogenic variants are associated with a recognizable syndromic neurodevelopmental disorder with short stature, obesity, craniofacial and digital abnormalities

PurposeProtein arginine methyltransferase 7 (PRMT7) is a member of a family of enzymes that catalyzes the methylation of arginine residues on several protein substrates. Biallelic pathogenic PRMT7 variants have previously been associated with a syndromic neurodevelopmental disorder characterized by short stature, brachydactyly, intellectual developmental disability, and seizures. To our knowledge, no comprehensive study describes the detailed clinical characteristics of this syndrome. Thus, we aim to delineate the phenotypic spectrum of PRMT7-related disorder.MethodsWe assembled a cohort of 51 affected individuals from 39 different families, gathering clinical information from 36 newly described affected individuals and reviewing data of 15 individuals from the literature.ResultsThe main clinical characteristics of the PRMT7-related syndrome are short stature, mild to severe developmental delay/intellectual disability, hypotonia, brachydactyly, and distinct facial morphology, including bifrontal narrowing, prominent supraorbital ridges, sparse eyebrows, short nose with full/broad nasal tip, thin upper lip, full and everted lower lip, and a prominent or squared-off jaw. Additional variable findings include seizures, obesity, nonspecific magnetic resonance imaging abnormalities, eye abnormalities (i.e., strabismus or nystagmus), and hearing loss.ConclusionThis study further delineates and expands the molecular, phenotypic spectrum and natural history of PRMT7-related syndrome characterized by a neurodevelopmental disorder with skeletal, growth, and endocrine abnormalities