4,001 research outputs found
The prevalence of medical reasons for non-participation in the Scottish breast and bowel cancer screening programmes
Objective: Increasing uptake of cancer screening is a priority for health systems internationally, however, some patients may not attend because they are undergoing active treatment for the cancer of interest or have other medical reasons that mean participation would be inappropriate. This study aims to quantify the proportion of non-participants who have a medical reason for not attending cancer screening.<p></p>
Methods: Medical reasons for not participating in breast and bowel screening were defined a priori on the basis of a literature review and expert opinion. The notes of 700 patients at two GP practices in Scotland were reviewed, to ascertain the prevalence of medical reasons amongst non-participants. Simple proportions and confidence intervals were calculated.<p></p>
Results: 17.4% of breast and 2.3% of bowel screening non-participants had a medical reason to not participate. The two most common reasons were previous breast cancer follow up (8.86%) and recent mammogram (6.57%).<p></p>
Conclusion: These patients may not benefit from screening while also being distressed by receiving an invitation. This issue also makes accurate monitoring and target-setting for improving uptake difficult. Further work is needed to estimate robustly the extent to which medical reasons account for screening non-participation in a larger population.<p></p>
The WIMP Forest: Indirect Detection of a Chiral Square
The spectrum of photons arising from WIMP annihilation carries a detailed
imprint of the structure of the dark sector. In particular, loop-level
annihilations into a photon and another boson can in principle lead to a series
of lines (a WIMP forest) at energies up to the WIMP mass. A specific model
which illustrates this feature nicely is a theory of two universal extra
dimensions compactified on a chiral square. Aside from the continuum emission,
which is a generic prediction of most dark matter candidates, we find a
"forest" of prominent annihilation lines that, after convolution with the
angular resolution of current experiments, leads to a distinctive (2-bump plus
continuum) spectrum, which may be visible in the near future with the Fermi
Gamma-Ray Space Telescope (formerly known as GLAST).Comment: 11 pages, 4 figure
Autocatalytic plume pinch-off
A localized source of buoyancy flux in a non-reactive fluid medium creates a
plume. The flux can be provided by either heat, a compositional difference
between the fluid comprising the plume and its surroundings, or a combination
of both. For autocatalytic plumes produced by the iodate-arsenous acid
reaction, however, buoyancy is produced along the entire reacting interface
between the plume and its surroundings. Buoyancy production at the moving
interface drives fluid motion, which in turn generates flow that advects the
reaction front. As a consequence of this interplay between fluid flow and
chemical reaction, autocatalytic plumes exhibit a rich dynamics during their
ascent through the reactant medium. One of the more interesting dynamical
features is the production of an accelerating vortical plume head that in
certain cases pinches-off and detaches from the upwelling conduit. After
pinch-off, a new plume head forms in the conduit below, and this can lead to
multiple generations of plume heads for a single plume initiation. We
investigated the pinch-off process using both experimentation and simulation.
Experiments were performed using various concentrations of glycerol, in which
it was found that repeated pinch-off occurs exclusively in a specific
concentration range. Autocatalytic plume simulations revealed that pinch-off is
triggered by the appearance of accelerating flow in the plume conduit.Comment: 10 figures. Accepted for publication in Phys Rev E. See also
http://www.physics.utoronto.ca/nonlinear/papers_chemwave.htm
Elucidating the structural composition of a Fe-N-C catalyst by nuclear and electron resonance techniques
Fe–N–C catalysts are very promising materials for fuel cells and metal–air batteries. This work gives fundamental insights into the structural composition of an Fe–N–C catalyst and highlights the importance of an in‐depth characterization. By nuclear‐ and electron‐resonance techniques, we are able to show that even after mild pyrolysis and acid leaching, the catalyst contains considerable fractions of α‐iron and, surprisingly, iron oxide. Our work makes it questionable to what extent FeN4 sites can be present in Fe–N–C catalysts prepared by pyrolysis at 900 °C and above. The simulation of the iron partial density of phonon states enables the identification of three FeN4 species in our catalyst, one of them comprising a sixfold coordination with end‐on bonded oxygen as one of the axial ligands
Exposure to Endocrine Disruptors and Nuclear Receptors Gene Expression in Infertile and Fertile Men from Italian Areas with Different Environmental Features
Internal levels of selected endocrine disruptors (EDs) (i.e., perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), di-2-ethylhexyl-phthalate (DEHP), mono-(2-ethylhexyl)-phthalate (MEHP), and bisphenol A (BPA)) were analyzed in blood/serum of infertile and fertile men from metropolitan, urban and rural Italian areas. PFOS and PFOA levels were also evaluated in seminal plasma. In peripheral blood mononuclear cells (PBMCs) of same subjects, gene expression levels of a panel of nuclear receptors (NRs), namely estrogen receptor α (ERα) estrogen receptor β (ERβ), androgen receptor (AR), aryl hydrocarbon receptor (AhR), peroxisome proliferator-activated receptor γ (PPARγ) and pregnane X receptor (PXR) were also assessed. Infertile men from the metropolitan area had significantly higher levels of BPA and gene expression of all NRs, except PPARγ, compared to subjects from other areas. Subjects from urban areas had significantly higher levels of MEHP, whereas subjects from rural area had higher levels of PFOA in both blood and seminal plasma. Interestingly, ERα, ERβ, AR, PXR and AhR expression is directly correlated with BPA and inversely correlated with PFOA serum levels. Our study indicates the relevance of the living environment when investigating the exposure to specific EDs. Moreover, the NRs panel in PBMCs demonstrated to be a potential biomarker of effect to assess the EDs impact on reproductive health
Comparison of the Toxicological Effects of Pesticides in Non-Tumorigenic MCF-12A and Tumorigenic MCF-7 Human Breast Cells
Humans are exposed to residues of organophosphate and neonicotinoid pesticides, commonly used in agriculture. Children are particularly vulnerable and, among possible adverse outcomes, the increased incidence of premature mammary gland development (thelarche) has raised concern. We evaluated the toxicological effects of chlorpyrifos (CPF), imidacloprid (IMI) and glyphosate (GLY) at exposure concentrations occurring in children on the tumorigenic MCF-7 and non-tumorigenic MCF-12A breast cell lines, as representative of the target organ model, assessing cytotoxicity, apoptosis, necrosis, intracellular reactive oxygen species (ROS) and ATP levels, 17β-estradiol secretion and gene expression of nuclear receptors involved in mammary gland development. The pesticides decreased cell vitality in MCF-7 and cell proliferation in MCF-12A cells. ATP levels were decreased in MCF-7 cells by pesticides and apoptosis was increased in MCF-12A cells only by GLY (2.3 nM). ROS production was decreased by pesticides in both cell lines, except IMI (1.6 nM) in MCF-7 cells. Endocrine disrupting activity was highlighted by induction of 17β-estradiol secretion and modulation of the gene expression of estrogen alpha and beta, progesterone, androgen, and aryl hydrocarbon receptors in both cell lines. The use of MCF-7 and MCF-12A cells highlighted dissimilar modes of action of each pesticide at low human relevant concentrations
Little Higgs models and single top production at the LHC
We investigate the corrections of the littlest Higgs(LH) model and the SU(3)
simple group model to single top production at the CERN Large Hardon
Collider(LHC). We find that the new gauge bosons predicted by the
LH model can generate significant contributions to single top production via
the s-channel process. The correction terms for the tree-level couplings
coming from the SU(3) simple group model can give large contributions to the
cross sections of the t-channel single top production process. We expect that
the effects of the LH model and the SU(3) simple group model on single top
production can be detected at the LHC experiments.Comment: 17pages, 5 figures, discussions and references added, typos correcte
Measuring the W-t-b Interaction at the ILC
The large top quark mass suggests that the top plays a pivotal role in
Electroweak symmetry-breaking dynamics and, as a result, may have modified
couplings to Electroweak bosons. Hadron colliders can provide measurements of
these couplings at the ~10% level, and one of the early expected triumphs of
the International Linear Collider is to reduce these uncertainties to the per
cent level. In this article, we propose the first direct measurement of the
Standard Model W-t-b coupling at the ILC, from measurements of t tbar-like
signals below the t tbar production threshold. We estimate that the ILC with
100 fb^{-1} can measure a combination of the coupling and top width to high
precision, and when combined with a direct measurement of the top width from
the above-threshold scan, results in a model-independent measurement of the
W-t-b interaction of the order of ~ 3%
Quaternion-Octonion SU(3) Flavor Symmetry
Starting with the quaternionic formulation of isospin SU(2) group, we have
derived the relations for different components of isospin with quark states.
Extending this formalism to the case of SU(3) group we have considered the
theory of octonion variables. Accordingly, the octonion splitting of SU(3)
group have been reconsidered and various commutation relations for SU(3) group
and its shift operators are also derived and verified for different iso-spin
multiplets i.e. I, U and V- spins.
Keywords: SU(3), Quaternions, Octonions and Gell Mann matrices
PACS NO: 11.30.Hv: Flavor symmetries; 12.10-Dm: Unified field theories and
models of strong and electroweak interaction
Frequency-wavenumber spectrum of the free surface of shallow turbulent flows over a rough boundary
Data on the frequency-wavenumber spectra and dispersion relation of the dynamic water surface in an open channel flow are very scarce. In this work, new data on the frequency-wavenumber spectra were obtained in a rectangular laboratory flume with a rough bottom boundary, over a range of subcritical Froude numbers. These data were used to study the dispersion relation of the surface waves in such shallow turbulent water flows. The results show a complex pattern of surface waves, with a range of scales and velocities. When the mean surface velocity is faster than the minimum phase velocity of gravity-capillary waves, the wave pattern is dominated by stationary waves that interact with the static rough bed. There is a coherent three-dimensional pattern of radially propagating waves with the wavelength approximately equal to the wavelength of the stationary waves. Alongside these waves, there are freely propagating gravity-capillary waves that propagate mainly parallel to the mean flow, both upstream and downstream. In the flow conditions where the mean surface velocity is slower than the minimum phase velocity of gravity-capillary waves, patterns of non-dispersive waves are observed. It is suggested that these waves are forced by turbulence. The results demonstrate that the free surface carries information about the underlying turbulent flow. The knowledge obtained in this study paves the way for the development of novel airborne methods of non-invasive flow monitoring
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