Antibiotics to improve recovery following tonsillectomy: a systematic review.

OBJECTIVE: To determine if antibiotics improve recovery following tonsillectomy. STUDY DESIGN: DATA SOURCES: Electronic databases Medline, Embase, and Cochrane Controlled Trials Register were searched using relevant search terms. Additional trials, if any, were retrieved by searching the references from all identified trials, reviews, correspondences, editorials, and conference proceedings. No language restriction was applied. STUDY SELECTION: Systematic review of trials in which antibiotic was administered as a study medication intraoperatively and/or postoperatively, in children or adults undergoing tonsillectomy or adenotonsillectomy. Only randomized, placebo-controlled, double-blind trials attaining preset quality scores were included. Outcomes analyzed: 1) pain, need for analgesia, fever, halitosis, and return to normal diet and activities; 2) secondary hemorrhage using 2 parameters-significant hemorrhage (ie, warranting readmission, blood transfusion, or return to theatre for hemostasis) and total hemorrhage; and 3) adverse events. RESULTS: Five trials met the eligibility criteria. Antibiotics significantly reduced the number of subjects manifesting fever (relative risk [RR]: 0.62, 95% confidence interval [CI]: 0.45, 0.85) and duration of halitosis (-1.94 [-3.57, -0.30] days), and marginally reduced the time taken to resume normal activity (-0.63 [-1.12, -0.14] days), but had no significant effect in reducing pain scores (-0.01 [-0.60, 0.57]) or need for analgesia. Similarly, there was no significant difference in the time taken to resume normal diet or incidence of significant and total hemorrhage, although data was underpowered to detect differences for these outcomes. In the antibiotic group 4 patients developed an adverse reaction (3 cases of rash and 1 case of oropharyngeal candidiasis), while in the control group 1 patient had an adverse reaction (rash). The RR of antibiotic-related adverse events was 2.45 (0.45, 13.31). CONCLUSION: Antibiotics appear to be effective in reducing some, but not all, morbid outcomes following tonsillectomy, and may increase the risk of adverse events. Further trials are needed to better define the role of antibiotics in facilitating post-tonsillectomy recovery. EBM RATING: A-1a

Catalytic Performance of Commercial Zeolites Y as Catalyst for Ethylene Production from Ethanol Dehydration

Catalytic dehydration of ethanol into ethylene was studied over commercial Zeolites-Y with different Si:Al ratios between 5.1:1 and 80:1, and temperature from 573 K to 773 K. The physicochemical properties of fresh and spent catalyst of Zeolite Y Si:Al 80:1 (best performing catalyst) were investigated using N2-physisorption, TGA, SEM-EDX, NH3-TPD, FTIR and XRD. Results showed that catalysts with higher Si:Al ratios exhibit better catalytic performance in terms of higher ethanol conversion and higher selectivity to ethylene. Indeed, zeolites-Y with Si:Al ratio 5.1:1 and 12:1 demonstrated low catalytic activity with ethanol conversion of 34% and 2%, respectively. However, ethylene selectivity of NH3-Y (5) was 84%, which was considerably higher than NH3-Y (12) which was 26%, indicated that this catalyst was not promoting the formation of other hydrocarbons i.e. methane and ethane. Albeit all of the catalysts namely H-Y (30), H-Y (60) and H-Y (80) showed favorable performance in ethanol dehydration, H-Y (80) attained almost total selectivity to ethylene and highest conversion of 73.0% among all the tested catalysts

The prevalence of insomnia in the general population in China: A meta-analysis

This is the first meta-analysis of the pooled prevalence of insomnia in the general population of China. A systematic literature search was conducted via the following databases: PubMed, PsycINFO, EMBASE and Chinese databases (China National Knowledge Interne (CNKI), WanFang Data and SinoMed). Statistical analyses were performed using the Comprehensive Meta-Analysis program. A total of 17 studies with 115,988 participants met the inclusion criteria for the analysis. The pooled prevalence of insomnia in China was 15.0% (95% Confidence interval [CI]: 12.1%-18.5%). No significant difference was found in the prevalence between genders or across time period. The pooled prevalence of insomnia in population with a mean age of 43.7 years and older (11.6%; 95% CI: 7.5%-17.6%) was significantly lower than in those with a mean age younger than 43.7 years (20.4%; 95% CI: 14.2%-28.2%). The prevalence of insomnia was significantly affected by the type of assessment tools (Q = 14.1, P = 0.001). The general population prevalence of insomnia in China is lower than those reported in Western countries but similar to those in Asian countries. Younger Chinese adults appear to suffer from more insomnia than older adults

Beyond advocacy: making space for conservation scientists in public debate

The topic of advocacy by scientists has been debated for decades, yet there is little agreement about whether scientists can or should be advocates. The fear of crossing a line into advocacy continues to hold many scientists back from contributing to public discourse, impoverishing public debate about important issues. We believe that progress in this debate is limited by a misconception about the relationship between scientific integrity and objectivity. We begin by unpacking this relationship and debunking three common misconceptions about advocacy by scientists: namely, that advocacy is harmful to scientific credibility, beyond the scope of science, and incompatible with science, which is value-free. We propose new ways of thinking about responsible advocacy by conservation scientists, drawing on practices from the health sciences, where researchers and professional bodies are empowered to act as health advocates.In so doing, we hope to open further space for conservation scientists to actively and legitimately engage in public debate about conservation issues

Image-guided Radiotherapy to Manage Respiratory Motion: Lung and Liver.

Organ motion as a result of respiratory and cardiac motion poses significant challenges for the accurate delivery of radiotherapy to both the thorax and the upper abdomen. Modern imaging techniques during radiotherapy simulation and delivery now permit better quantification of organ motion, which in turn reduces tumour and organ at risk position uncertainty. These imaging advances, coupled with respiratory correlated radiotherapy delivery techniques, have led to the development of a range of approaches to manage respiratory motion. This review summarises the key strategies of image-guided respiratory motion management with a focus on lung and liver radiotherapy

Immunopathology of Virus-Induced Anterior Uveitis

Herpes simplex virus, varicella zoster virus, human cytomegalovirus, and rubella virus are the most common causes of virus-induced anterior uveitis. They can present in a variety of entities not only with typical but also overlapping clinical ch

Indoor path loss model for 4G wireless network at 2.6 GHz

In this paper, a short-range, narrowband indoor propagation at 2.6 GHz was measured and modeled. The measurement campaign was conducted to characterize the path loss (PL) of Radio frequency (RF) at the Razak School building corridor. The corridor has unique structure and segmented in different sections. The irregular structure of corridor, further with various interior material used gives the unique characterization to the received power. The research work made in this paper is predominately targets to characterizing radio link of 2.6 GHz frequency in typical indoor corridor

Dissolved heavy metals and water quality in the surface waters of rivers and drainages of the West Peninsular Malaysia

The dissolved concentrations of metals (Cd, Cu, Pb, Ni, Fe and Zn), temperature, total dissolved solids, pH, dissolved oxygen, salinity and conductivity were determined in the surface waters of 24 geographical sampling sites including city and urban drainages and rivers, from the west Peninsular Malaysia, collected in January to April 2005. From these sampling sites, the ranges (min-max) of dissolved metal concentrations (mg/L) were Cd: 0.001-0.055, Cu: 0.001-0.1773, Pb: 0.001-1.523, Ni: 0.001-0.246, Fe: 0.001-35.67 and Zn: 0.0001-0.609 while for the water quality are pH: 4.96-9.81, dissolved oxygen (0.39-7.26 mg/L), total dissolved solids (0.002-10.02 mg/L), salinity (0.00-8.93 ppt), conductivity (3.33-17423 μS/cm) and temperature (27.8-35.3�). Some sites with elevated dissolved concentrations of heavy metals and poor water quality indicated the anthropogenic inputs of industrial and urban wastes. Regular monitoring of water quality in all drainage waters is recommended