Do early-life exposures explain why more advantaged children get eczema? Findings from the U.K. Millennium Cohort Study

Background: Atopic dermatitis (eczema) in childhood is socially patterned, with higher incidence in more advantaged populations. However, it is unclear what factors explain the social differences. Objectives: To identify early-life risk factors for eczema, and to explore how early-life risk factors explain any differences in eczema. Methods: We estimated odds ratios (ORs) for ever having had eczema by age 5 years in 14 499 children from the U.K. Millennium Cohort Study (MCS), with a focus on maternal, antenatal and early-life risk factors and socioeconomic circumstances (SECs). Risk factors were explored to assess whether they attenuated associations between SECs and eczema. Results: Overall 35·1% of children had ever had eczema by age 5 years. Children of mothers with degree-level qualifications vs. no educational qualifications were more likely to have eczema (OR 1·52, 95% confidence interval 1·31–1·76), and there was a gradient across the socioeconomic spectrum. Maternal atopy, breastfeeding (1–6 weeks and ≥ 6 months), introduction of solids under 4 months or cow's milk under 9 months, antibiotic exposure in the first year of life and grime exposure were associated with an increased odds of having eczema. Female sex, Pakistani and Bangladeshi ethnicity, smoking during pregnancy, exposure to environmental tobacco smoke and having more siblings were associated with reduced odds for eczema. Controlling for maternal, antenatal and early-life characteristics (particularly maternal smoking during pregnancy, breastfeeding and number of siblings) reduced the OR for eczema to 1·26 (95% confidence interval 1·03–1·50) in the group with the highest educational qualifications compared with the least. Conclusions: In a representative U.K. child cohort, eczema was more common in more advantaged children. This was explained partially by early-life factors including not smoking during pregnancy, breastfeeding and having fewer siblings

Multiphoton entanglement through a Bell multiport beam splitter

Multiphoton entanglement is an important resource for linear optics quantum computing. Here we show that a wide range of highly entangled multiphoton states, including W-states, can be prepared by interfering single photons inside a Bell multiport beam splitter and using postselection. A successful state preparation is indicated by the collection of one photon per output port. An advantage of the Bell multiport beam splitter is that it redirects the photons without changing their inner degrees of freedom. The described setup can therefore be used to generate polarisation, time-bin and frequency multiphoton entanglement, even when using only a single photon source.Comment: 8 pages, 2 figures, carefully revised version, references adde

A mid-infrared survey of the inner 2 × 1.5 degrees of the Galaxy with Spitzer/IRAC

We present a survey of Spitzer Space Telescope/IRAC observations of the central 2 × 1.5 degrees (265 × 200 pc) of the Galaxy at 3-8 μm. These data represent the highest spatial resolution and sensitivity large-scale map made to date of the Galactic Center (GC) at mid-infrared wavelengths. The IRAC data provide a census of the optically obscured stellar sources as well as a detailed map of the highly filamentary structure in the interstellar medium. The diffuse emission is dominated by PAH emission from small grains in star-forming regions. Dark clouds displaying a large variety of sizes and morphologies are imaged, many of which remain opaque at IRAC wavelengths. Using a multiwavelength comparison, we determine which objects are likely to be in the foreground and which are located at the GC. We find no counterparts at IRAC wavelengths to the unique system of linear, nonthermal radio filaments present at the GC

STEM Engagement with NASA's Solar System Treks Portals for Lunar and Planetary Mapping and Modeling

This presentation will provide an overview of the uses and capabilities of NASA's Solar System Treks family of online mapping and modeling portals. While also designed to support mission planning and scientific research, this presentation will focus on the Science, Technology, Engineering, and Math (STEM) engagement and public outreach capabilities of these web based suites of data visualization and analysis tools

Emission location dependent ozone depletion potentials for very short-lived halogenated species

International audienceWe present trajectory-based estimates of Ozone Depletion Potentials (ODPs) for very short-lived halogenated source gases as a function of surface emission location. The ODPs are determined by the fraction of source gas and its degradation products which reach the stratosphere, depending primarily on tropospheric transport and chemistry, and the effect of the resulting reactive halogen in the stratosphere, which is determined by stratospheric transport and chemistry, in particular by stratospheric residence time. Reflecting the different timescales and physico-chemical processes in the troposphere and stratosphere, the estimates are based on calculation of separate ensembles of trajectories for the troposphere and stratosphere. A methodology is described by which information from the two ensembles can be combined to give the ODPs

Atom-photon entanglement generation and distribution

We extend an earlier model by Law {\it et al.} \cite{law} for a cavity QED based single-photon-gun to atom-photon entanglement generation and distribution. We illuminate the importance of a small critical atom number on the fidelity of the proposed operation in the strong coupling limit. Our result points to a promisingly high purity and efficiency using currently available cavity QED parameters, and sheds new light on constructing quantum computing and communication devices with trapped atoms and high Q optical cavities.Comment: 7 fig

The mid-infrared colors of the interstellar medium and extended sources at the Galactic center

A mid-infrared (3.6–8 μm) survey of the Galactic center has been carried out with the IRAC instrument on the Spitzer Space Telescope. This survey covers the central 2º x 1.4º (~280 x 200 pc) of the Galaxy. At 3.6 and 4.5 μm the emission is dominated by stellar sources, the fainter ones merging into an unresolved background. At 5.8 and 8 μm the stellar sources are fainter, and large-scale diffuse emission from the ISM of the Galaxy's central molecular zone becomes prominent. The survey reveals that the 8-to-5.8 μm color of the ISM emission is highly uniform across the surveyed region. This uniform color is consistent with a flat extinction law and emission from polycyclic aromatic hydrocarbons (PAHs). Models indicate that this broadband color should not be expected to change if the incident radiation field heating the dust and PAHs is ~10^4 times that of the solar neighborhood. Other regions of very red emission indicate cases where thick dust clouds obscure deeply embedded objects or very early stages of star formation

Dynamic and Energetic Stabilization of Persistent Currents in Bose-Einstein Condensates

We study conditions under which vortices in a highly oblate harmonically trapped Bose-Einstein condensate (BEC) can be stabilized due to pinning by a blue-detuned Gaussian laser beam, with particular emphasis on the potentially destabilizing effects of laser beam positioning within the BEC. Our approach involves theoretical and numerical exploration of dynamically and energetically stable pinning of vortices with winding number up to $S=6$, in correspondence with experimental observations. Stable pinning is quantified theoretically via Bogoliubov-de Gennes excitation spectrum computations and confirmed via direct numerical simulations for a range of conditions similar to those of experimental observations. The theoretical and numerical results indicate that the pinned winding number, or equivalently the winding number of the superfluid current about the laser beam, decays as a laser beam of fixed intensity moves away from the BEC center. Our theoretical analysis helps explain previous experimental observations, and helps define limits of stable vortex pinning for future experiments involving vortex manipulation by laser beams.Comment: 8 pages 5 figure

Stability of Filters for the Navier-Stokes Equation

Data assimilation methodologies are designed to incorporate noisy observations of a physical system into an underlying model in order to infer the properties of the state of the system. Filters refer to a class of data assimilation algorithms designed to update the estimation of the state in a on-line fashion, as data is acquired sequentially. For linear problems subject to Gaussian noise filtering can be performed exactly using the Kalman filter. For nonlinear systems it can be approximated in a systematic way by particle filters. However in high dimensions these particle filtering methods can break down. Hence, for the large nonlinear systems arising in applications such as weather forecasting, various ad hoc filters are used, mostly based on making Gaussian approximations. The purpose of this work is to study the properties of these ad hoc filters, working in the context of the 2D incompressible Navier-Stokes equation. By working in this infinite dimensional setting we provide an analysis which is useful for understanding high dimensional filtering, and is robust to mesh-refinement. We describe theoretical results showing that, in the small observational noise limit, the filters can be tuned to accurately track the signal itself (filter stability), provided the system is observed in a sufficiently large low dimensional space; roughly speaking this space should be large enough to contain the unstable modes of the linearized dynamics. Numerical results are given which illustrate the theory. In a simplified scenario we also derive, and study numerically, a stochastic PDE which determines filter stability in the limit of frequent observations, subject to large observational noise. The positive results herein concerning filter stability complement recent numerical studies which demonstrate that the ad hoc filters perform poorly in reproducing statistical variation about the true signal