Freedom of the Land and Freedom of the Seas

During the present war at least three separate demands have been made in a public and formal way that peace must bring with it freedom of the seas

The Knight Commander Case

Although but one of several instances of the same sort, involving the question of the legality of the destruction of a neutral ship by a belligerent, the sinking of the Knight Commander excited so much adverse comment in England at the time and has given rise to so much discussion since, as to make it a test case, one upon which it is convenient to base an inquiry

China and Japan

The spectacle of Japan marching side by side with European powers and with the United States, to rescue their ministers and its own from Chinese violation of the sacred rights of embassy, is one of the most striking of which it is possible to conceive. Half a century ago these two powers, China and Japan, entered modern political society on the same footing

The Bering Sea Award

During the present year one more instance has been added to a list already considerable and honorable, of disputes successfully settled by special arbitration on the part of Great Britain and the United States. The award of the commission, to which the settlement of five questions relating to the sealing controversy was referred, was made in August. It may be of interest to attempt very briefly to state what was and what was not decided by this award, and to characterize the policy of our government and the arguments of our counsel in view of it. The facts agreed upon between the parties were that the fur seal was largely diminished in numbers and seemed threatened with extinction. But there existed an irreconcilable difference of opinion as to the cause of this, the experts of the United States, most of them, holding that pelagic slaughter was accountable for it, while those of Great Britain maintained that these unhappy results sprang from the unscientific methods of killing on the Pribilof Islands, practiced by the licensees. The question at issue was this: Has the United States acquired, either through an exclusive jurisdiction over the waters of Bering Sea or through a property right in seals breeding there, the right to protect them in the open sea by force, or must such protection spring from the joint action of the two governments? And if the latter is true, what regulations are necessary to accomplish the purpose? The fact that Great Britain was willing to join in the reference of this latter question, is an important one. It indicated clearly, what she had maintained throughout, though not always with sufficient energy to overcome the hampering influences of the British colonies on this continent, that she desired to preserve the seals from threatened extinction, that the real question was one of method, but that she objected to the assertion of exclusive right in the matter by the United States. This fact should be taken as the key to her policy. It certainly made the task of our government simpler and, as may appear later, its second policy of doubtful expediency

DrugBank: a comprehensive resource for in silico drug discovery and exploration

DrugBank is a unique bioinformatics/cheminformatics resource that combines detailed drug (i.e. chemical) data with comprehensive drug target (i.e. protein) information. The database contains >4100 drug entries including >800 FDA approved small molecule and biotech drugs as well as >3200 experimental drugs. Additionally, >14 000 protein or drug target sequences are linked to these drug entries. Each DrugCard entry contains >80 data fields with half of the information being devoted to drug/chemical data and the other half devoted to drug target or protein data. Many data fields are hyperlinked to other databases (KEGG, PubChem, ChEBI, PDB, Swiss-Prot and GenBank) and a variety of structure viewing applets. The database is fully searchable supporting extensive text, sequence, chemical structure and relational query searches. Potential applications of DrugBank include in silico drug target discovery, drug design, drug docking or screening, drug metabolism prediction, drug interaction prediction and general pharmaceutical education. DrugBank is available at