140 research outputs found
Guillain-Barré syndrome: a century of progress
In 1916, Guillain, Barré and Strohl reported on two cases of acute flaccid paralysis with high cerebrospinal fluid protein levels and normal cell counts — novel findings that identified the disease we now know as Guillain–Barré syndrome (GBS). 100 years on, we have made great progress with the clinical and pathological characterization of GBS. Early clinicopathological and animal studies indicated that GBS was an immune-mediated demyelinating disorder, and that severe GBS could result in secondary axonal injury; the current treatments of plasma exchange and intravenous immunoglobulin, which were developed in the 1980s, are based on this premise. Subsequent work has, however, shown that primary axonal injury can be the underlying disease. The association of Campylobacter jejuni strains has led to confirmation that anti-ganglioside antibodies are pathogenic and that axonal GBS involves an antibody and complement-mediated disruption of nodes of Ranvier, neuromuscular junctions and other neuronal and glial membranes. Now, ongoing clinical trials of the complement inhibitor eculizumab are the first targeted immunotherapy in GBS
The Forgotten Equality Norm in Immigration Preemption: Discrimination, Harassment, and the Civil Rights Act of 1870
The Quest for Uniformity in Mediation Confidentiality: Foolish Consistency or Crucial Predictability?
A produção cientĂfica sobre docĂŞncia em saĂşde: um estudo em periĂłdicos nacionais
President's proclamation. June 15, 1917. I hereby designate the period June twenty-third toJune thirtieth, next, recruiting week for the regular army and call upon unmarried men between the ages of eighteen and forty years ... to present themsel
You can help beat the draft.; U. S. President. 1913-1921 Wilson President's proclamation
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