The hepatitis C virus 3′-untranslated region or a poly(A) tract promote efficient translation subsequent to the initiation phase

Enhancement of eukaryotic messenger RNA (mRNA) translation initiation by the 3′ poly(A) tail is mediated through interaction of poly(A)-binding protein with eukaryotic initiation factor (eIF) 4G, bridging the 5′ terminal cap structure. In contrast to cellular mRNA, translation of the uncapped, non-polyadenylated hepatitis C virus (HCV) genome occurs independently of eIF4G and a role for 3′-untranslated sequences in modifying HCV gene expression is controversial. Utilizing cell-based and in vitro translation assays, we show that the HCV 3′-untranslated region (UTR) or a 3′ poly(A) tract of sufficient length interchangeably stimulate translation dependent upon the HCV internal ribosomal entry site (IRES). However, in contrast to cap-dependent translation, the rate of initiation at the HCV IRES was unaffected by 3′-untranslated sequences. Analysis of post-initiation events revealed that the 3′ poly(A) tract and HCV 3′-UTR improve translation efficiency by enabling termination and possibly ribosome recycling for successive rounds of translation

Excitation of the 2s State of Atomic Hydrogen by Electron Impact in the Distorted-Wave Approximation - Angular Distributions

The excitation of ground-state hydrogen atoms to the 2s state by the impact of electrons with energies of 1 to 50 Ry (13.6 to 680.3 eV) has been calculated in the distorted-wave approximation with exchange included. The angular distributions of the scattered electrons at 1 and 4 Ry are compared with those derived from the close-coupling calculations by Burke, Schey, and Smith, and are compared with four different plane-wave theories at all energies calculated. Taking the close-coupling results as a standard, it is found that the distorted-wave angular distributions represent an improvement over those of the plane-wave theories

An Effective Theory for Midgap States in Doped Spin Ladder and Spin-Peierls Systems: Liouville Quantum Mechanics

In gapped spin ladder and spin-Peierls systems the introduction of disorder, for example by doping, leads to the appearance of low energy midgap states. The fact that these strongly correlated systems can be mapped onto one dimensional noninteracting fermions provides a rare opportunity to explore systems which have both strong interactions and disorder. In this paper we show that the statistics of the zero energy midgap wave functions in these models can be effectively described by Liouville Quantum Mechanics. This enables us to calculate the disorder averaged N-point correlation functions of these states (the explicit calculation is performed for N=2,3). We find that whilst these midgap states are typically weakly correlated, their disorder averaged correlation are power law. This discrepancy arises because the correlations are not self-averaging and averages of the wave functions are dominated by anomalously strongly correlated configurations.Comment: 13 page latex fil

Bound states of magnons in the S=1/2 quantum spin ladder

We study the excitation spectrum of the two-leg antiferromagnetic S=1/2 Heisenberg ladder. Our approach is based on the description of the excitations as triplets above a strong-coupling singlet ground state. The quasiparticle spectrum is calculated by treating the excitations as a dilute Bose gas with infinite on-site repulsion. We find singlet (S=0) and triplet (S=1) two-particle bound states of the elementary triplets. We argue that bound states generally exist in any dimerized quantum spin model.Comment: 4 REVTeX pages, 4 Postscript figure

Superconductivity in a spin liquid - a one dimensional example

We study a one-dimensional model of interacting conduction electrons with a two-fold degenerate band away from half filling. The interaction includes an on-site Coulomb repulsion and Hund's rule coupling. We show that such one-dimensional system has a divergent Cooper pair susceptibility at T = 0, provided the Coulomb interaction $U$ between electrons on the same orbital and the modulus of the Hund's exchange integral $|J|$ are larger than the interorbital Coulomb interaction. It is remarkable that the superconductivity can be achieved for {\it any} sign of $J$. The opening of spectral gaps makes this state stable with respect to direct electron hopping between the orbitals. The scaling dimension of the superconducting order parameter is found to be between 1/4 (small $U$) and 1/2 (large $U$).Comment: 11 pages, Latex, no figure

Variability in H9N2 haemagglutinin receptor-binding preference and the pH of fusion

H9N2 avian influenza viruses are primarily a disease of poultry; however, they occasionally infect humans and are considered a potential pandemic threat. Little work has been performed to assess the intrinsic biochemical properties related to zoonotic potential of H9N2 viruses. The objective of this study, therefore, was to investigate H9N2 haemagglutinins (HAs) using two well-known correlates for human adaption: receptor-binding avidity and pH of fusion. Receptor binding was characterized using bio-layer interferometry to measure virus binding to human and avian-like receptor analogues and the pH of fusion was assayed by syncytium formation in virus-infected cells at different pHs. We characterized contemporary H9N2 viruses of the zoonotic G1 lineage, as well as representative viruses of the zoonotic BJ94 lineage. We found that most contemporary H9N2 viruses show a preference for sulphated avian-like receptor analogues. However, the ‘Eastern’ G1 H9N2 viruses displayed a consistent preference in binding to a human-like receptor analogue. We demonstrate that the presence of leucine at position 226 of the HA receptor-binding site correlated poorly with the ability to bind a human-like sialic acid receptor. H9N2 HAs also display variability in their pH of fusion, ranging between pH 5.4 and 5.85 which is similar to that of the first wave of human H1N1pdm09 viruses but lower than the pH of fusion seen in zoonotic H5N1 and H7N9 viruses. Our results suggest possible molecular mechanisms that may underlie the relatively high prevalence of human zoonotic infection by particular H9N2 virus lineages

Renormalized SO(5) symmetry in ladders with next-nearest-neighbor hopping

We study the occurrence of SO(5) symmetry in the low-energy sector of two-chain Hubbard-like systems by analyzing the flow of the running couplings ($g$-ology) under renormalization group in the weak-interaction limit. It is shown that SO(5) is asymptotically restored for low energies for rather general parameters of the bare Hamiltonian. This holds also with inclusion of a next-nearest-neighbor hopping which explicitly breaks particle-hole symmetry provided one accounts for a different single-particle weight for the quasiparticles of the two bands of the system. The physical significance of this renormalized SO(5) symmetry is discussed.Comment: Final version: to appear in Phys. Rev. Lett., sched. Mar. 9

NS-NS fluxes in Hitchin's generalized geometry

The standard notion of NS-NS 3-form flux is lifted to Hitchin's generalized geometry. This generalized flux is given in terms of an integral of a modified Nijenhuis operator over a generalized 3-cycle. Explicitly evaluating the generalized flux in a number of familiar examples, we show that it can compute three-form flux, geometric flux and non-geometric Q-flux. Finally, a generalized connection that acts on generalized vectors is described and we show how the flux arises from it.Comment: 21 pages, 1 figure; v3: minor change