8 research outputs found
Tenuazonic Acid: A Promising Antitubercular Principle from Alternaria alternate
Bioactivity guided isolation of dichloromethane extract of Alternaria alternata identified tenuazonic acid (1) as potentially active against Mycobacterium tuberculosis H37Rv, MIC at 250 μg/mL concentration. This active metabolite 1, was also evaluated for osmotic hemolysis using the erythrocyte as a model system. It was observed that this fungal metabolite showing antitubercular activity exhibited concentration dependent toxicity to human erythrocytes