ISSN 2141-6532 ©2011 Academic Journals

Mixed medullary and follicular carcinoma of the thyroid – A rare entit

Case Report Section: Pathology A lesion on lip -Hemangioma with Chronic Granuloma

ABSTRACT Infections as well as tumours and tumour-like conditions are common in the oral cavity. While hemangiomas are benign vascular tumours which may be encountered in any part of the body, granulomatous infections are unusual in the mouth. We discuss below the rare occurrence of a hemangioma on the lip which was associated with a chronic granuloma

Rare orbital malignancies in xeroderma pigmentosum – a case series and review of literature

Xeroderma pigmentosum (XP) is a rare genodermatosis, with a defect affecting recovery of ultraviolet-induced damages and characterized by a high rate of malignancies of the exposed skin areas. Inheritance is autosomal recessive and consanguinity of parents is common. We report two siblings with a history of consanguinity having XP with rare orbital malignancies. The first case had orbital amelanotic melanoma and the second case had sebaceous gland carcinoma (SGC) with orbital extension. In this case series, we have discussed and reviewed orbital malignancies in XP with respect to this report and other cases in the literature. Although early detection and treatment of these malignancies will reduce morbidity and mortality, genetic counselling remains the most important protective measures for XP.</jats:p

A comparison of cytological and histopathological findings and role of immunostains in the diagnosis of soft tissue tumors

Background: Fine needle aspiration cytology (FNAC) has been employed as a useful technique for the initial diagnosis of soft tissue tumors (STT) as well for the identification of recurrent and metastatic cases. Aim: We conducted this study on soft tissue tumors to find the efficacy of FNAC and to finalize the histological diagnosis with immunostains. Materials and Methods: The present study was conducted on 126 patients of soft tissue tumors. FNAC and histopathology was performed in all the cases. Results: Hundred and five cases (83.3%) were diagnosed as benign and 21 cases (16.7%) as malignant. On FNAC, tumors were divided into six cytomorphological categories i.e. lipomatous, spindle cell, round cell, myxoid, pleomorphic and vascular tumors. Seventeen cases were inconclusive on cytology. In five cases, the type of malignancy was changed on histological examination. There were three false positive and two false negative cases giving a positive predictive value of 97.2 % in terms of malignancy, a sensitivity of 98.1% and a specificity of 96.7%. Conclusions: FNAC has a definite role in forming the initial diagnosis of STT, while histopathology with the aid of immunomarkers provides the final diagnosis