The Mitochondrial Ca(2+) Uniporter: Structure, Function, and Pharmacology.

Mitochondrial Ca(2+) uptake is crucial for an array of cellular functions while an imbalance can elicit cell death. In this chapter, we briefly reviewed the various modes of mitochondrial Ca(2+) uptake and our current understanding of mitochondrial Ca(2+) homeostasis in regards to cell physiology and pathophysiology. Further, this chapter focuses on the molecular identities, intracellular regulators as well as the pharmacology of mitochondrial Ca(2+) uniporter complex

Bilateral ovarian teratoma complicated with carcinosarcoma in a 68 year old woman: a case report

<p>Abstract</p> <p>Background</p> <p>Composing of less than 1% of all ovarian cancers, immature teratoma is a malignancy that mainly affects the young, and they present with advanced disease. The treatment of immature teratoma is conservative primary surgery usually involving unilateral salpingo-oophorectomy followed by combination chemotherapy.</p> <p>Case presentation</p> <p>Here we present a case of a 68 year old woman with bilateral ovarian teratoma complicated with carcinosarcoma. The patient was diagnosed as FIGO stage IIIC. She underwent neoadjuvant chemotherapy and interval cytoreduction followed by optimal cytoreduction. The post operative management strategies and gynaecological follow up studies revealed no evidence of regional or distant metastasis.</p> <p>Conclusion</p> <p>Thus the choice of initial treatment should be decided in a selective fashion depending on various prognostic factors in order to increase the survival of the patients.</p

Assessment of health seeking behaviour among fishermen community in Puducherry

Background: Fishermen community are involved in dangerous and complex profession and have diverse and untold constrains like work overtime in sea- nightshifts and late- night return from sea which worsen their morbid conditions.  Objectives were to explore the health seeking behaviour and challenges faced by the fishermen community to utilize the health care facility in Puducherry.Methods: A community based cross-sectional study was conducted among 102 individuals in the selected villages of fishermen community in Puducherry based on convenient sampling during September 2019 to November 2019.Results: Majority 63 (62.4%) utilized government hospitals for various illness. Nearly one-third of people 35 (34.5%) visited private hospital for their ailments and another 4 (3.9%) preferred pharmacies for their illness. More than half of the study participants working as an active fisherman 59 (57.8%) had approached health care facility during their illness (p&lt;0.037). Around 54 (52.9%) subjects belonged to lower middle class visited health facility during their illness (p&lt;0.046). Free of cost, 24×7 services, and easy accessibility, were reported as the commonest reason for choosing public health facility. Doctors availability, less time consumption and quality of medical care were the reasons for preferring private practitioners.Conclusions: Strengthening of public health care services near the fishermen community area is required to promote their health seeking behaviour. Also, special focus to be given for appropriate transport facility and arranging specialized healthcare professionals for this community. </jats:p