Exact Anisotropic Solutions of the Generalized TOV Equation

We explore gravitating relativistic spheres composed of an anisotropic, barotropic uid. We assume a bi-polytropic equation of state which has a linear and a power-law terms. The generalized Tolman-Oppenheimer-Volkoff (TOV) equation which describes the hydrostatic equilibrium is obtained. The full system of equations are solved for solutions which are regular at the origin and asymptotically flat. Conditions for the appearance of horizon and a basic treatment of stability are also discussed.Comment: 14 pages, 9 figure

Peritoneal Potassium and pH Measurement in Early Diagnosis of Acute Mesenteric Ischemia in Rats

Background: In contemporary practice, acute mesenteric ischemia (AMI) remains a serious cause of morbidity and mortality in abdominal emergencies. Objectives: We report the measurement of peritoneal fluid potassium and pH on a small series of rats that developed extensive AMI following the surgical ligation of superior mesenteric vessels and compare the results with control groups. Materials and Methods: A total of 32 rats were used in our study. They were divided into four groups with eight rats in each one and received following treatments: group I (G-I), 60-minute controls; group II (G-II), 120-minute controls; group III (G-III), 60-minute cases; and group IV (G-IV), 120-minute cases. In case groups, the small bowel mesenteric root was double-ligated and an arrow single-lumen central venous catheter was passed through the skin to the peritoneum. In control groups, the catheter was placed without any intervention. Postoperatively, peritoneal lavage was performed at 60 (G-I, G-III) and 120 minutes (G-II, G-IV). Results: The mean peritoneal potassium values were 1.3 ± 0.3, 1.97 ± 1.06, 2.14 ± 0.89, and 3.28 ± 0.66 mmol/L in G-I, G-II, G-III, and G-IV, respectively. There were significant differences between G-III and G-IV (P = 0.002), between G-I and G-III (P = 0.024), and between G-II and G-IV (P = 0.001). The mean values of peritoneal fluid pH were 7.1 ± 0.26, 6.82 ± 0.22, 6.66 ± 0.16, and 6.78 ± 0.04 in G-I, G-II, G-III, and G-IV, respectively, which indicated significant differences between G-I and G-III (P = 0.001) and between G-II and G-IV (P = 0.018). There was a significant correlation between peritoneal fluid potassium and intestine ischemic grade (F = 4.77, P = 0.048) Conclusions: Our findings show that for early detection of bowel ischemia, an evaluation of intraperitoneal potassium and pH was useful and with prolongation of ischemia, potassium changes were more significant

Effectiveness of Reconfigurable Intelligent Surfaces to Enhance Connectivity in UAV Networks

Reconfigurable intelligent surfaces (RISs) are expected to make future 6G networks more connected and resilient against node failures, due to their ability to introduce controllable phase-shifts onto impinging electromagnetic waves and impose link redundancy. Meanwhile, unmanned aerial vehicles (UAVs) are prone to failure due to limited energy, random failures, or targeted failures, which causes network disintegration that results in information delivery loss. In this paper, we show that the integration between UAVs and RISs for improving network connectivity is crucial. We utilize RISs to provide path diversity and alternative connectivity options for information flow from user equipments (UEs) to less critical UAVs by adding more links to the network, thereby making the network more resilient and connected. To that end, we first define the criticality of UAV nodes, which reflects the importance of some nodes over other nodes. We then employ the algebraic connectivity metric, which is adjusted by the reflected links of the RISs and their criticality weights, to formulate the problem of maximizing the network connectivity. Such problem is a computationally expensive combinatorial optimization. To tackle this problem, we propose a relaxation method such that the discrete scheduling constraint of the problem is relaxed and becomes continuous. Leveraging this, we propose two efficient solutions, namely semi-definite programming (SDP) optimization and perturbation heuristic, which both solve the problem in polynomial time. For the perturbation heuristic, we derive the lower and upper bounds of the algebraic connectivity obtained by adding new links to the network. Finally, we corroborate the effectiveness of the proposed solutions through extensive simulation experiments.Comment: 14 pages, 8 figures, journal paper. arXiv admin note: text overlap with arXiv:2308.0467

Energy Efficient Communications in RIS-assisted UAV Networks Based on Genetic Algorithm

This paper proposes a solution for energy-efficient communication in reconfigurable intelligent surface (RIS)-assisted unmanned aerial vehicle (UAV) networks. The limited battery life of UAVs is a major concern for their sustainable operation, and RIS has emerged as a promising solution to reducing the energy consumption of communication systems. The paper formulates the problem of maximizing the energy efficiency of the network as a mixed integer non-linear program, in which UAV placement, UAV beamforming, On-Off strategy of RIS elements, and phase shift of RIS elements are optimized. The proposed solution utilizes the block coordinate descent approach and a combination of continuous and binary genetic algorithms. Moreover, for optimizing the UAV placement, Adam optimizer is used. The simulation results show that the proposed solution outperforms the existing literature. Specifically, we compared the proposed method with the successive convex approximation (SCA) approach for optimizing the phase shift of RIS elements

Immunomodulation and Generation of Tolerogenic Dendritic Cells by Probiotic Bacteria in Patients with Inflammatory Bowel Disease

In inflammatory bowel diseases (IBD), the therapeutic benefit and mucosal healing from specific probiotics may relate to the modulation of dendritic cells (DCs). Herein, we assessed the immunomodulatory effects of four probiotic strains including Lactobacillus salivarius, Bifidobacterium bifidum, Bacillus coagulans and Bacillus subtilis natto on the expression of co-stimulatory molecules, cytokine production and gene expression of signal-transducing receptors in DCs from IBD patients. Human monocyte-derived DCs from IBD patients and healthy controls were exposed to four probiotic strains. The expression of co-stimulatory molecules was assessed and supernatants were analyzed for anti-inflammatory cytokines. The gene expression of toll-like receptors (TLRs), IL-12p40 and integrin \u3b1v\u3b28 were also analyzed. CD80 and CD86 were induced by most probiotic strains in ulcerative colitis (UC) patients whereas only B. bifidum induced CD80 and CD86 expression in Crohn's disease (CD) patients. IL-10 and TGF-\u3b2 production was increased in a dose-independent manner while TLR expression was decreased by all probiotic bacteria except B. bifidum in DCs from UC patients. TLR-4 and TLR-9 expression was significantly downregulated while integrin f8 was significantly increased in the DCs from CD patients. IL-12p40 expression was only significantly downregulated in DCs from CD patients. Our findings point to the general beneficial effects of probiotics in DC immunomodulation and indicate that probiotic bacteria favorably modulate the expression of co-stimulatory molecules, proinflammatory cytokines and TLRs in DCs from IBD patients

Thrombus Formation: Direct Real‐Time Observation and Digital Analysis of Thrombus Assembly in a Living Mouse by Confocal and Widefield Intravital Microscopy

We have developed novel instrumentation using confocal and widefield microscopy to image and analyze thrombus formation in real time in the microcirculation of a living mouse. This system provides high-speed, near-simultaneous acquisition of images of multiple fluorescent probes and a brightfield channel, and supports laser-induced injury through the microscope optics. Although this imaging facility requires interface of multiple hardware components, the primary challenge in vascular imaging is careful experimental design and interpretation. This system has been used to localize tissue factor during thrombus formation, to observe defects in thrombus assembly in genetically altered mice, to study the kinetics of platelet activation and P-selectin expression following vascular injury, to analyze leukocyte rolling on arterial thrombi, to generate three-dimensional models of thrombi, and to analyze the effect of antithrombotic agents in vivo

N=1/2 Super Yang-Mills Theory on Euclidean AdS2xS2

We study D-branes in the background of Euclidean AdS2xS2 with a graviphoton field turned on. As the background is not Ricci flat, the graviphoton field must have both self-dual and antiself-dual parts. This, in general, will break all the supersymmetries on the brane. However, we show that there exists a limit for which one can restore half of the supersymmetries. Further, we show that in this limit, the N=1/2 SYM Lagrangian on flat space can be lifted on to the Euclidean AdS2xS2 preserving the same amount of supersymmetries as in the flat case. We observe that without the C-dependent terms present in the action this lift is not possible.Comment: 12 pages, latex file; v2: minor corrections, references adde

Tamoxifen-Induced Apoptosis of MCF-7 Cells via GPR30/PI3K/MAPKs Interactions: Verification by ODE Modeling and RNA Sequencing.

Tamoxifen (Nolvadex) is one of the most widely used and effective therapeutic agent for breast cancer. It benefits nearly 75% of patients with estrogen receptor (ER)-positive breast cancer that receive this drug. Its effectiveness is mainly attributed to its capacity to function as an ER antagonist, blocking estrogen binding sites on the receptor, and inhibiting the proliferative action of the receptor-hormone complex. Although, tamoxifen can induce apoptosis in breast cancer cells via upregulation of pro-apoptotic factors, it can also promote uterine hyperplasia in some women. Thus, tamoxifen as a multi-functional drug could have different effects on cells based on the utilization of effective concentrations or availability of specific co-factors. Evidence that tamoxifen functions as a GPR30 (G-Protein Coupled Receptor 30) agonist activating adenylyl cyclase and EGFR (Epidermal Growth Factor Receptor) intracellular signaling networks, provides yet another means of explaining the multi-functionality of tamoxifen. Here ordinary differential equation (ODE) modeling, RNA sequencing and real time qPCR analysis were utilized to establish the necessary data for gene network mapping of tamoxifen-stimulated MCF-7 cells, which express the endogenous ER and GPR30. The gene set enrichment analysis and pathway analysis approaches were used to categorize transcriptionally upregulated genes in biological processes. Of the 2,713 genes that were significantly upregulated following a 48 h incubation with 250 μM tamoxifen, most were categorized as either growth-related or pro-apoptotic intermediates that fit into the Tp53 and/or MAPK signaling pathways. Collectively, our results display that the effects of tamoxifen on the breast cancer MCF-7 cell line are mediated by the activation of important signaling pathways including Tp53 and MAPKs to induce apoptosis

Concomitant Carcinoma in situ in Cystectomy Specimens Is Not Associated with Clinical Outcomes after Surgery

Objective: The aim of this study was to externally validate the prognostic value of concomitant urothelial carcinoma in situ (CIS) in radical cystectomy (RC) specimens using a large international cohort of bladder cancer patients. Methods: The records of 3,973 patients treated with RC and bilateral lymphadenectomy for urothelial carcinoma of the bladder (UCB) at nine centers worldwide were reviewed. Surgical specimens were evaluated by a genitourinary pathologist at each center. Uni- and multivariable Cox regression models addressed time to recurrence and cancer-specific mortality after RC. Results: 1,741 (43.8%) patients had concomitant CIS in their RC specimens. Concomitant CIS was more common in organ-confined UCB and was associated with lymphovascular invasion (p < 0.001). Concomitant CIS was not associated with either disease recurrence or cancer-specific death regardless of pathologic stage. The presence of concomitant CIS did not improve the predictive accuracy of standard predictors for either disease recurrence or cancer-specific death in any of the subgroups. Conclusions: We could not confirm the prognostic value of concomitant CIS in RC specimens. This, together with the discrepancy between pathologists in determining the presence of concomitant CIS at the morphologic level, limits the clinical utility of concomitant CIS in RC specimens for clinical decision-making. Copyright (C) 2011 S. Karger AG, Base