Concurrent acute myeloid leukemia and T lymphoblastic lymphoma in a patient with rearranged PDGFRB genes

Concurrent hematologic malignancies are relatively rare. We encountered a case of concurrent acute myeloid leukemia (AML) and T lymphoblastic lymphoma. The bone marrow chromosome analysis showed the karyotype 46, XY, t(5;12)(q33;p13), which indicated presence of PDGFRB gene translocations. Therefore, this disease belongs to the new WHO category of myeloid and lymphoid neoplasms with abnormalities in PDGFRA, PDGFRB and FGFR1 genes. Although such genetic mutations are prone to multi-lineage differentiation, the present case is in fact the first report of concurrent AML and T lymphoblastic lymphoma involving PDGFRB mutations. The patient was treated with cytarabine and daunomycin in combination with high dose dexamethasone. Allogeneic stem cell transplantation was performed after successful remission induction for both entities. The patient eventually died of chronic graft-versus-host-disease related infection. Based on such an experience, we suggest the decision of stem cell transplantation should be weighed carefully against the risks, especially when tyrosine kinase inhibitors are safe and potentially effective in dealing with such entities

ALLOGENEIC RELATED DONOR STEM CELL TRANSPLANTATION IN AML CR1: ANY RISK FACTOR FOR BETTER SURVIVAL?

40th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantation -- MAR 30-APR 02, 2014 -- Milan, ITALYWOS: 000359941901036…European Grp Blood & Marrow Transplanta

AUTOLOGOUS STEM CELL COLLECTION IN LYMPHOMA AND MYELOMA PATIENTS: SINGLE CENTER ANALYSIS WITH INTENT TO SUCCESSFULLY MOBILIZE AND TRANSPLANT

40th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantation -- MAR 30-APR 02, 2014 -- Milan, ITALYWOS: 000359941901255…European Grp Blood & Marrow Transplanta

Extraskeletal multiple myeloma presenting with an atrial mass: a case report and a review of the literature

<p>Abstract</p> <p>Introduction</p> <p>Extraskeletal presentation at diagnosis or during the course of multiple myeloma is a rare event. The prognosis is usually very poor. At the moment there is no agreed gold standard for the treatment of this presentation.</p> <p>Case presentation</p> <p>A 79-year-old Caucasian woman was treated at our hospital for right atrial myeloma localization. Our patient showed the following signs and symptoms of congestive heart failure: dyspnea, hypotension, cyanosis and facial edema. Surgery was not considered feasible due to the extent of the disease. Our patient underwent external-beam radiation therapy using an intensity modulated technique, thus obtaining a persistent complete remission. Our patient has been in continuous complete local remission for 25 months since the end of radiotherapy.</p> <p>Conclusion</p> <p>The role of radiotherapy is not defined in multiple myeloma with extraskeletal presentation. Our regimen seems to be effective in controlling the disease in this patient.</p> <p>This case report adds to the existing literature as it describes an unusual presentation of the disease and a new therapeutic approach to this rare presentation of multiple myeloma.</p