Evaluation of Lucerne Cultivars for Dry Matter and Seed Production in Latvia

Lucerne is highly productivity and has a high quality. Nevertheless, lucerne growing in Latvia is limited, because of a large area of acid soils (pHKCl\u3c5.8) as well as low and unstable seed yields (Berzins, 2002). In recent years lucerne has taken a more important place in forage production in Latvia, because it is a fast growing crop and in good years gives 3-4 harvests per season. It is important to determine which cultivars of lucerne are more productive and give good seed yields every year in Latvia (Luksa, 2002)

The Productive Longevity Of Perennial Grasses Swards Depending On The Npk Fertilizer Rates

The longevity and producing capacity of perennial grasses swards was studied on mineral soils at the LUA Research Institute of Agriculture in long-term experiment during 1974-2010. There were applied lime and mineral fertilizers with different NPK doses (0-400 kg ha-1) protractedly many years. In such way there formed soils with various content of P, K, organic matter content and pHKCl level as well. Research results showed that liming of soils and using of mineral fertilizer changed not only productivity of grass mixtures but also botanical composition. Mineral fertilizer N200P100K300 provided the highest yield of dry matter – 7.32 - 12.0 t ha-1 and optimal botanical composition of a sward during many years. On unlimed soils (pHKCL less then 4.0 in 1997) dry matter yields of grass sward was substantially lower and there was observed disappearance of seeded valuable grasses out of the sward and increase of herbs and non-seeded grasses –Festuca rubra L., Agrostis tenuis Sibth., Taraxacum officinale Wigg. and others. Liming of soils increased dry matter yield in treatments with high doses of N (300-400) fertilizer

Effect of Lignosilicon on the Content and Antioxidant Activity of the Polyphenols of Buckwheat Fagopyrum esculentum Moench

Lignin preparations, introduced into soil jointly with buckwheat Fagopyrum esculentum Moench, variety 'Aiva' (cultivated throughout Latvia) seeds during the sowing in quantities of 20 kg ha-1 and 40 kg ha-1, exerted a favourable effect on the ned in alcohol extracts from the biomass of different morphological parts of buckwheat, were represented mainly by rutin. The content of rutin in the ethanol extracts from the biomass of flowers with bract reached the maximum values in the phase of accomplishing blooming - beginning of fruit formation to be 2.74% in terms of dry mass (exceeding the rutin content development of plants and the synthesis of flavonoids in flowers with bract. Flavonoids, determin the control by 65%) in the variant with 40 kg ha-1 of Lignosilicon. Lignin preparations favoured the increase in the radical scavenging capacity of the alcohol extracts of the biomass of flowers with bract of buckwheat, as well as grain and hulls. The increment of the buckwheat grain crop, in comparison with the control on the background of 40 kg ha-1 of lignin, was 12%, and that on the background of 20 kg ha-1 and 40 kg/ha of Lignosilicon 10% and 15%, respectively

Carbon and nitrogen uptake in above- and below-ground biomass of cereal crops in the integrated farming system

Received: February 1st, 2023 ; Accepted: April 8th, 2023 ; Published: April 24th, 2023 ; Correspondence: [email protected] significant reduction in greenhouse gas (GHG) emissions, as well as technologies that ensure removal of CO2 from the atmosphere, are necessary to achieve the set goals for the transition to carbon neutrality. During the crop growth cycle, a significant amount of biomass is produced, and carbon (C) and nitrogen (N) are captured both by the harvested crop removed from the field and by residues left on the field. The trials were conducted to find out patterns between crop and residues while trying to figure out the amount of captured C and N. In this study data of the most widely grown cereal crops in Latvia are summarized. The data are representative, obtained in different agroclimatic conditions, they vary both by species and variety, by year and fertilizers applied. The mean amount of biomass from cereal crops left on the field was 1,070.9 g m-2 DM, besides, 906.7 g m-2 of that was made up of above-ground (AG) residues and 164.2 g m-2 of below-ground (BG) residues. On average, 471.8 g m-2 C and 14.3 g m-2 N were captured, including: 411.2 g m-2 C and 12.9 g m-2 N by AG residues; 60.7 g m-2 C and 1.4 g m-2 N by BG residues. Regularities between grain yield and residues were found, however, they were not very strong. The dataset should be enlarged to reduce uncertainty. As the data calculated from crop have a greater uncertainty, the GHG inventory should be calculated according to the average AG and BG biomass, which provide more accurate data

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P = 0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P = 0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P = 0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P = 0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P = 0.31). Conclusions: Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. (Funded by Novartis; CANTOS ClinicalTrials.gov number, NCT01327846.

Contemporary Presentation and Management of Valvular Heart Disease The EURObservational Research Programme Valvular Heart Disease II Survey

International audienceBackground: Valvular heart disease (VHD) is an important cause of mortality and morbidity and has been subject to important changes in management. The VHD II survey was designed by the EURObservational Research Programme of the European Society of Cardiology to analyze actual management of VHD and to compare practice with guidelines. Methods: Patients with severe native VHD or previous valvular intervention were enrolled prospectively across 28 countries over a 3-month period in 2017. Indications for intervention were considered concordant if the intervention was performed or scheduled in symptomatic patients, corresponding to Class I recommendations specified in the 2012 European Society of Cardiology and in the 2014 American Heart Association/American College of Cardiology VHD guidelines. Results: A total of 7247 patients (4483 hospitalized, 2764 outpatients) were included in 222 centers. Median age was 71 years (interquartile range, 62-80 years); 1917 patients (26.5%) were >= 80 years; and 3416 were female (47.1%). Severe native VHD was present in 5219 patients (72.0%): aortic stenosis in 2152 (41.2% of native VHD), aortic regurgitation in 279 (5.3%), mitral stenosis in 234 (4.5%), mitral regurgitation in 1114 (21.3%; primary in 746 and secondary in 368), multiple left-sided VHD in 1297 (24.9%), and right-sided VHD in 143 (2.7%). Two thousand twenty-eight patients (28.0%) had undergone previous valvular intervention. Intervention was performed in 37.0% and scheduled in 26.8% of patients with native VHD. The decision for intervention was concordant with Class I recommendations in symptomatic patients with severe single left-sided native VHD in 79.4% (95% CI, 77.1-81.6) for aortic stenosis, 77.6% (95% CI, 69.9-84.0) for aortic regurgitation, 68.5% (95% CI, 60.8-75.4) for mitral stenosis, and 71.0% (95% CI, 66.4-75.3) for primary mitral regurgitation. Valvular interventions were performed in 2150 patients during the survey; of them, 47.8% of patients with single left-sided native VHD were in New York Heart Association class III or IV. Transcatheter procedures were performed in 38.7% of patients with aortic stenosis and 16.7% of those with mitral regurgitation. Conclusions: Despite good concordance between Class I recommendations and practice in patients with aortic VHD, the suboptimal number in mitral VHD and late referral for valvular interventions suggest the need to improve further guideline implementation

Cohort profile. the ESC-EORP chronic ischemic cardiovascular disease long-term (CICD LT) registry

The European Society of cardiology (ESC) EURObservational Research Programme (EORP) Chronic Ischemic Cardiovascular Disease registry Long Term (CICD) aims to study the clinical profile, treatment modalities and outcomes of patients diagnosed with CICD in a contemporary environment in order to assess whether these patients at high cardiovascular risk are treated according to ESC guidelines on prevention or on stable coronary disease and to determine mid and long term outcomes and their determinants in this population