La Cueva Gorge (Humahuaca, Jujuy): chronology, space and archaeological pottery

El trabajo discute distintos aspectos de la quebrada de La Cueva: cronología, espacialidad y cerámica, puntualizando en la evidencia de sitios no trabajados previamente. Se presenta un panorama global de la quebrada para vincularla con el área Surandina e integrarla a la realidad de la Quebrada de Humahuaca en sus diferentes momentos de ocupación, dado que se considera que se trata de un sector septentrional de esta última. Los datos cronológicos pueden ser de utilidad para quienes estudian dicha quebrada, dado que complementan modelos del uso del espacio planteados previamente. estos análisis muestran que, por lo menos, el Pukara de La Cueva estuvo ocupado desde los Desarrollos Regionales II hasta el período Incaico. Además los estudios sobre cerámica, arquitectura, agricultura, funebria e intercambio con otras zonas abren el panorama para la quebrada de La Cueva y su comparación con otras zonas.In this paper a number of diverse aspects (chronology, spatial record, pottery, etc.) will be discussed for the area of La Cueva gorge, particularly the unpublished sites, aiming at providing a global view of the gorge and relate it to the larger context of the different occupational periods described for the Humahuaca gorge, as part of its northern section. Furthermore, the analysis will be later extended to the Southern Andes situation. Chronological data have been included in previous spatial models of the Humahuaca gorge and are readily available, depicting an occupation from at least Regional Developments II to the Inka period in La Cueva pukara. Additionally, analyses of pottery, architecture, agriculture, funerary practices and exchange with other areas enlarge the picture of La Cueva gorge and its comparison with other areas.Sociedad Argentina de Antropologí

Thyroid nodules treated with percutaneous radiofrequency thermal ablation: a comparative study

Percutaneous radiofrequency thermal ablation (RTA) was reported as an effective tool for the management of thyroid nodules (TNs). The aim of this study was to investigate the effects of RTA and to establish whether they were treatment-related by comparison with a matched, untreated control group

Inheritance of resistance to Sporisorium sorghi in grain sorghum

Greenhouse and field experiments were conducted in 1995, in Kansas, USA, to investigate the inheritance of resistance to covered kernel smut (Sporisorium sorghi) in sorghum cultivars B35-6, SC414 and Sureño. In all crosses, the susceptible parent was BTx623. Crosses were made between resistant and susceptible accessions to determine inheritance. Crosses between resistant accessions were used to determine if they possessed the same genes. Resistant parents remained immune to S. sorghi under both field and greenhouse conditions. The incidence (76%) of smutted panicles of BTx623 grown under greenhouse conditions was substantially higher than that in BTx623 grown in the field (2.3%). The reactions of F1 progenies of the crosses B35-6 × Sureño and Sureño × BTx623 suggest incomplete dominance of resistance. There was a very limited amount of F1 seed from the other resistant × susceptible crosses and therefore no conclusion could be reached on the reactions of their progenies to S. sorghi. A 3:1 ratio of resistant to susceptible plants was obtained in the F2 population of Sureño × BTx623, suggesting incomplete dominance. Higher smut incidence in the F1 progeny of Sureño × BTx623 was observed, indicating incomplete dominance of resistance from Sureno

Prediction of response to vemurafenib in BRAF V600E mutant cancers based on a network approach

Lung adenocarcinoma is the tumor with the highest number of switch genes (298) compared to its normal tissue, followed by thyroid (227) and colorectal (183) cancers. Switch genes codifying for kinases were 14,7 and 3 respectively.We looked for three homology sequences identified across vemurafenib targets and we found that thyroid cancer and lung adenocarcinoma have a similar number of putative targetable switch genes kinase (5-6); on the contrary, colorectal cancer has just one,with minor homology sequence

Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil

Cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Manaus, Brazil, resurged in late 2020 despite previously high levels of infection. Genome sequencing of viruses sampled in Manaus between November 2020 and January 2021 revealed the emergence and circulation of a novel SARS-CoV-2 variant of concern. Lineage P.1 acquired 17 mutations, including a trio in the spike protein (K417T, E484K, and N501Y) associated with increased binding to the human ACE2 (angiotensin-converting enzyme 2) receptor. Molecular clock analysis shows that P.1 emergence occurred around mid-November 2020 and was preceded by a period of faster molecular evolution. Using a two-category dynamical model that integrates genomic and mortality data, we estimate that P.1 may be 1.7- to 2.4-fold more transmissible and that previous (non-P.1) infection provides 54 to 79% of the protection against infection with P.1 that it provides against non-P.1 lineages. Enhanced global genomic surveillance of variants of concern, which may exhibit increased transmissibility and/or immune evasion, is critical to accelerate pandemic responsiveness

Computing, Design, Art: Reflections on an Innovative Moment in History

The paper is concerned with the role of art and design in the history and philosophy of computing. It offers insights arising from research into a period in the 1960s and 70s, particularly in the UK, when computing became more available to artists and designers, focusing on John Lansdown (1929-1999) and Bruce Archer (1922-2005) in London. Models of computing interacted with conceptualisations of art, design and related creative activities in important ways

Coexpressed subunits of dual genetic origin define a conserved supercomplex mediating essential protein import into chloroplasts

In photosynthetic eukaryotes, thousands of proteins are translated in the cytosol and imported into the chloroplast through the concerted action of two translocons-termed TOC and TIC-located in the outer and inner membranes of the chloroplast envelope, respectively. The degree to which the molecular composition of the TOC and TIC complexes is conserved over phylogenetic distances has remained controversial. Here, we combine transcriptomic, biochemical, and genetic tools in the green alga Chlamydomonas (Chlamydomonas reinhardtii) to demonstrate that, despite a lack of evident sequence conservation for some of its components, the algal TIC complex mirrors the molecular composition of a TIC complex from Arabidopsis thaliana. The Chlamydomonas TIC complex contains three nuclear-encoded subunits, Tic20, Tic56, and Tic100, and one chloroplast-encoded subunit, Tic214, and interacts with the TOC complex, as well as with several uncharacterized proteins to form a stable supercomplex (TIC-TOC), indicating that protein import across both envelope membranes is mechanistically coupled. Expression of the nuclear and chloroplast genes encoding both known and uncharacterized TIC-TOC components is highly coordinated, suggesting that a mechanism for regulating its biogenesis across compartmental boundaries must exist. Conditional repression of Tic214, the only chloroplast-encoded subunit in the TIC-TOC complex, impairs the import of chloroplast proteins with essential roles in chloroplast ribosome biogenesis and protein folding and induces a pleiotropic stress response, including several proteins involved in the chloroplast unfolded protein response. These findings underscore the functional importance of the TIC-TOC supercomplex in maintaining chloroplast proteostasis