Archaeological Perspectives on the Southern Appalachians: A Multiscalar Approach

In the last four decades, southeastern archaeology has increasingly developed a processual method of looking at archaeological data through varying levels of scale. By adjusting the scale, archaeologists can further define societal interactions and exchanges, which is particularly useful to those researching the Mississippian period, as the rise and fall of chiefdoms was both internally complex and externally influenced by broader regional factors. This use of the most current research methods has enabled a more comprehensive understanding of prehistoric and historic sociopolitical entities. In Archaeological Perspectives of the Southern Appalachians, Ramie A. Gougeon and Maureen S. Meyers have brought together a dozen archaeologists to delineate multiscalar approaches to Native American sites throughout southern Appalachia. The essays range in topic from ceramic assemblages in northern Georgia to public architecture in North Carolina to the frontiers of southern Appalachia in Virginia. Throughout the volume, the contributors discuss varying scales of analysis in their own research to flesh out the importance of maintaining different perspectives when evaluating archaeological evidence. Additionally, the volume makes particular reference to the work of David Hally, whose influence on not only the editors and contributors but on southeastern archaeology as a whole cannot be overstated. While Hally was neither a pioneer nor vocal champion of scale variation, his impeccable research, culminating with the publication of his magnum opus King: The Social Archaeology of a Late Mississippian Town in Northwestern Georgia paved the way for younger scholars to truly develop research methods for holistic social archaeology.https://egrove.olemiss.edu/libarts_book/1076/thumbnail.jp

Malaria Parasite Infection Compromises Control of Concurrent Systemic Non-typhoidal Salmonella Infection via IL-10-Mediated Alteration of Myeloid Cell Function

Non-typhoidal Salmonella serotypes (NTS) cause a self-limited gastroenteritis in immunocompetent individuals, while children with severe Plasmodium falciparum malaria can develop a life-threatening disseminated infection. This co-infection is a major source of child mortality in sub-Saharan Africa. However, the mechanisms by which malaria contributes to increased risk of NTS bacteremia are incompletely understood. Here, we report that in a mouse co-infection model, malaria parasite infection blunts inflammatory responses to NTS, leading to decreased inflammatory pathology and increased systemic bacterial colonization. Blunting of NTS-induced inflammatory responses required induction of IL-10 by the parasites. In the absence of malaria parasite infection, administration of recombinant IL-10 together with induction of anemia had an additive effect on systemic bacterial colonization. Mice that were conditionally deficient for either myeloid cell IL-10 production or myeloid cell expression of IL-10 receptor were better able to control systemic Salmonella infection, suggesting that phagocytic cells are both producers and targets of malaria parasite-induced IL-10. Thus, IL-10 produced during the immune response to malaria increases susceptibility to disseminated NTS infection by suppressing the ability of myeloid cells, most likely macrophages, to control bacterial infection

Compton imaging for enhanced sensitivity (n,γ) cross section TOF experiments: Status and prospects

Radiative neutron-capture cross sections are of pivotal importance in many fields such as nucle-osynthesis studies or innovative reactor technologies. A large number of isotopes have been measured with high accuracy, but there are still a large number of relevant isotopes whose cross sections could not be experimentally determined yet, at least with sufficient accuracy and completeness, owing to limitations in detection techniques, sample production methods or in the facilities themselves. In the context of the HYMNS (High-sensitivitY Measurements of key stellar Nucleo-Synthesis reactions) project over the last six years we have developed a novel detection technique aimed at background suppression in radiative neutron-capture time-of-flight measurements. This new technique utilizes a complex detection set-up based on position-sensitive radiation-detectors deployed in a Compton-camera array configuration. The latter enables to implement gamma-ray imaging techniques, which help to disentangle true capture events arising from the sample under study and contaminant background events from the surroundings. A summary on the main developments is given in this contribution together with an update on recent experiments at CERN n_TOF and an outlook on future steps