550 research outputs found
Classicité de formes modulaires surconvergentes
We prove in this paper a classicality result for overconvergent modular forms on PEL Shimura varieties of type (A) or (C) associated to an unramified reductive group on . To get this result, we use the analytic continuation method, first used by Buzzard and Kassaei
The usefulness of c-Kit in the immunohistochemical assessment of melanocytic lesions
C-Kit (CD117), the receptor for the stem cell factor, a growth factor for melanocyte migra- tion and proliferation, has shown differential immunostaining in various benign and malig- nant melanocytic lesions. The purpose of this study is to compare c-Kit immunostaining in benign nevi and in primary and metastatic malignant melanomas, to determine whether c-Kit can aid in the differential diagnosis of these lesions. c-Kit immunostaining was per- formed in 60 cases of pigmented lesions, including 39 benign nevi (5 blue nevi, 5 intra- dermal nevi, 3 junctional nevi, 15 cases of pri- mary compound nevus, 11 cases of Spitz nevus), 18 cases of primary malignant melanoma and 3 cases of metastatic melanoma. The vast majority of nevi and melanomas examined in this study were posi- tive for c-Kit, with minimal differences between benign and malignant lesions. C-Kit cytoplasmatic immunoreactivity in the intraepidermal proliferating nevus cells, was detected in benign pigmented lesions as well as in malignant melanoma, increasing with the age of patients (P=0.007) in both groups. The patient’s age at presentation appeared to be the variable able to cluster benign and malignant pigmented lesions. The percentage of c-Kit positive intraepidermal nevus cells was better associated with age despite other vari- ables (P=0.014). The intensity and percentage of c-Kit positivity in the proliferating nevus cells in the dermis was significantly increased in malignant melanocytic lesions (P=0.015 and P=0.008) compared to benign lesions (compound melanocytic nevi, Spitz nevi, intradermal nevi, blue nevi). Immunostaning for c-Kit in metastatic melanomas was nega- tive. Interestingly in two cases of melanoma occurring on a pre-existent nevus, the melanoma tumor cells showed strong cytoplas- matic and membranous positivity for c-kit, in contrast with the absence of any immunoreac- tivity in pre-existent intradermal nevus cells. C-Kit does not appear to be a strong immuno- histochemical marker for distinguishing melanoma from melanocytic nevi, if we consid- er c-Kit expression in intraepidermal prolifer- ating cells. The c-Kit expression in proliferat- ing melanocytes in the dermis could help in the differential diagnosis between a superfi- cial spreading melanoma (with dermis inva- sion) and a compound nevus or an intradermal nevus. Finally, c-Kit could be a good diagnostic tool for distinguishing benign compound nevi from malignant melanocytic lesions with der- mis invasion and to differentiate metastatic melanoma from primary melanoma
Estimating carbon dioxide fluxes from temperate mountain grasslands using broad-band vegetation indices
The broad-band normalised difference vegetation index (NDVI) and the simple ratio (SR) were calculated from measurements of reflectance of photosynthetically active and short-wave radiation at two temperate mountain grasslands in Austria and related to the net ecosystem CO<sub>2</sub> exchange (NEE) measured concurrently by means of the eddy covariance method. There was no significant statistical difference between the relationships of midday mean NEE with narrow- and broad-band NDVI and SR, measured during and calculated for that same time window, respectively. The skill of broad-band NDVI and SR in predicting CO<sub>2</sub> fluxes was higher for metrics dominated by gross photosynthesis and lowest for ecosystem respiration, with NEE in between. A method based on a simple light response model whose parameters were parameterised based on broad-band NDVI allowed to improve predictions of daily NEE and is suggested to hold promise for filling gaps in the NEE time series. Relationships of CO<sub>2</sub> flux metrics with broad-band NDVI and SR however generally differed between the two studied grassland sites indicting an influence of additional factors not yet accounted for
On the Equivalence of Three-Particle Scattering Formalisms
In recent years, different on-shell scattering
formalisms have been proposed to be applied to both lattice QCD and infinite
volume scattering processes. We prove that the formulation in the infinite
volume presented by Hansen and Sharpe in Phys.~Rev.~D92, 114509 (2015) and
subsequently Brice\~no, Hansen, and Sharpe in Phys.~Rev.~D95, 074510 (2017) can
be recovered from the -matrix representation, derived on the basis of
-matrix unitarity, presented by Mai {\em et al.} in Eur.~Phys.~J.~A53, 177
(2017) and Jackura {\em et al.} in Eur.~Phys.~J.~C79, 56 (2019). Therefore,
both formalisms in the infinite volume are equivalent and the physical content
is identical. Additionally, the Faddeev equations are recovered in the
non-relativistic limit of both representations.Comment: 13 pages, 5 figure
TAN: A Distributed Algorithm for Dynamic Task Assignment in WSNs
We consider the scenario of wireless sensor networks where a given application has to be deployed and each application task has to be assigned to each node in the best possible way. Approaches where decisions on task execution are taken by a single central node can avoid the exchange of data packets between task execution nodes but cannot adapt to dynamic network conditions, and suffer from computational complexity. To address this issue, in this paper, we propose an adaptive and decentralized task allocation negotiation algorithm (TAN) for cluster network topologies. It is based on noncooperative game theory, where neighboring nodes engage in negotiations to maximize their own utility functions to agree on which of them should execute single application tasks. Performance is evaluated in a city scenario, where the urban streets are equipped with different sensors and the application target is the detection of the fastest way to reach a destination, and in random WSN scenarios. Comparisons are made with three other algorithms: 1) baseline setting with no task assignment to multiple nodes; 2) centralized task assignment lifetime optimization; and 3) a dynamic distributed algorithm, DLMA. The result is that TAN outperforms these algorithms in terms of application completion time and average energy consumption.
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Cooperative task assignment for distributed deployment of applications in WSNs
Nodes in Wireless Sensor Networks (WSNs) are becoming more and more complex systems with the capabilities to run distributed structured applications. Which single task should be implemented by each WSN node needs to be decided by the application deployment strategy by taking into account both network lifetime and execution time requirements. In this paper, we propose an adaptive decentralised algorithm based on noncooperative game theory, where neighbouring nodes negotiate among each other to maximize their utility function. We then prove that an increment of the nodes utility corresponds to the same increment of the utility for the whole network. Simulation results show significant performance improvement with respect to existing algorithms
Grain size reduction strategies on Eurofer
One of the options currently taken into account for the realization of the first DEMO reactor is the "water-cooled blanket". This option implies a minimum irradiation temperature for the blanket material in the range of 280–350 °C. In addition to the DBTT (Ductile to Brittle Transition Temperature) shift due to the DPA (displacement per atom) damage under irradiation, also the issue of the increased embrittlement due to He production must be taken into account. This issue appears even more detrimental and less manageable because the DBBT shift due to the Helium production does not saturate with the dose, as it results from previous works reported in literature. The experimental results and the difference in behaviour between ODS (Oxide Dispersion Strengthened Steels) RAFM (Reduced Activation Ferritic Martensitic) and other FM (Ferritic Martensitic) alloys (EM10, P91) showed that it is possible to improve the resistance to He embrittlement by both intra-granular precipitation of Y-Ti oxides and by decreasing the grain size at the same time. Nevertheless, anyway, the multiplication of the grain boundaries increases the dilution of He on grain surface, delaying the formation of He bubbles on grain boundaries and, therefore, the susceptibility to the He embrittlement. Several grain size reduction strategies have then been investigated on EUROFER both at the austenitization stage, on the PAGS (Prior Austenite Grain Size), and at the tempering stage, on the tempered martensite. The microstructural observations have been carried out by means of SEM (Scanning Electron Microscopy). Also the effect of grain size reduction on the toughness of the material will be taken into account; The DBTTs resulting from impact tests on KLST specimens will be shown. The outcomes of the microstructural observations, as well as the preliminary mechanical characterization (impact tests) will be discussed in this paper. Keywords: EUROFER 97, RAFM steels, Microstructure, Multiple normalization, Asymmetric rolling, Recrystallization, KLS
Predicting workout quality to help coaches support sportspeople
The support of a qualified coach is crucial to keep the motivation of sportspeople high and help them pursuing an active lifestyle. In this paper,we discuss the scenario in which a coach follows sportspeople remotely by means of an eHealth platform, named u4fit. Having to deal with several users at the same time, with no direct human contact, means that it is hard for coaches to quickly spot who, among the people she follows, needs a more timely support. To this end, in this paper we present an automated approach that analyzes the adherence of sportspeople to their planned workout routines. The approach is able to suggest to the coach the sportspeople who need earlier support due to a poor performance. Experiments on real data, evaluated through classic accuracy metrics, show the effectiveness of our approach
Melanoma occurrence under long-term etanercept treatment for psoriasis: a case report
Melanoma occurrence during treatment with anti-tumor necrosis factor is considered an incidental event, although very recent studies suggest a risk. Etanercept is a fusion protein that binds the tumor necrosis factor receptor and is included among TNF inhibitors, approved for the treatment of several autoimmune diseases, such as psoriasis.We described a 79-year-old man with psoriasis, being treated with etanercept, who presented with a new brown to black macule on his right shoulder; this was immediately surgically excised. Histology showed a superficial spreading melanoma, 1.2 mm Breslow thickness, one mitosis/hpf, with no vascular or neural invasion (stage T2b). Sentinel lymph node biopsy was negative. There were no apparent melanoma risk factors: normal total nevus count, photo type IV, no childhood sunburns, no family history of melanoma, and no previous immune suppressive drugs and/or phototherapies. Etanercept 50 mg/week had been administered continuously for 5 years before the melanoma occurrence. After etanercept withdrawal his psoriasis slowly, but progressively relapsed
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