New hybrid multi-criteria decision-making DEMATELMAIRCA model: sustainable selection of a location for the development of multimodal logistics centre

The paper describes the application of a new multi-criteria decision-making (MCDM) model, MultiAtributive Ideal-Real Comparative Analysis (MAIRCA), used to select a location for the development of a multimodal logistics centre by the Danube River. The MAIRCA method is based on the comparison of theoretical and empirical alternative ratings. Relying on theoretical and empirical ratings the gap (distance) between the empirical and ideal alternative is defined. To determine the weight coefficients of the criteria, the DEMATEL method was applied. In this paper, through a sensitivity analysis, the results of MAIRCA and other MCDM methods – MOORA, TOPSIS, ELECTRE, COPRAS and PROMETHEE – were compared. The analysis showed that a smaller or bigger instability in alternative rankings appears in MOORA, TOPSIS, ELECTRE and COPRAS. On the other hand, the analysis showed that MAIRCA and PROMETHEE offer consistent solutions and have a stable and wellstructured analytical framework for ranking the alternatives. By presenting a new method MCDM expands the theoretical framework of expertise in the field of MCDM. This enables the analysis of practical problems with new methodology and creates a basis for further theoretical and practical upgrade

Difficulties in establishing a timely diagnosis of pulmonary artery sarcoma misdiagnosed as chronic thrombo-embolic pulmonary disease: a case report

<p>Abstract</p> <p>Introduction</p> <p>Pulmonary artery sarcomas are rare neoplasms that are often confused with chronic thrombo-embolic disease, as both can have similar clinical and imaging presentation.</p> <p>Case presentation</p> <p>In this report, we present a case of a 50-year-old man initially diagnosed with chronic thrombo-embolic pulmonary disease, but who was later found to have pulmonary artery sarcoma with poor survival prognosis. We review the clinical and imaging characteristics of the two diseases and discuss the difficulties in establishing a timely diagnosis.</p> <p>Conclusion</p> <p>Similar clinical features and imaging presentation of pulmonary artery sarcoma and chronic thrombo-embolic pulmonary disease make definitive diagnosis difficult. This case report also illustrates and emphasizes that in any case with no predisposition factors for embolism, no evidence of deep venous thrombosis and pulmonary emboli, and inadequate relief of symptoms with anticoagulation, an alternative diagnosis of pulmonary artery sarcoma should be considered. If pulmonary artery sarcoma is diagnosed late in the course of the disease, there is usually a poor survival outcome.</p

Salmonella enterica Serovar Typhimurium Lacking hfq Gene Confers Protective Immunity against Murine Typhoid

Salmonella enterica is an important enteric pathogen and its various serovars are involved in causing both systemic and intestinal diseases in humans and domestic animals. The emergence of multidrug-resistant strains of Salmonella leading to increased morbidity and mortality has further complicated its management. Live attenuated vaccines have been proven superior over killed or subunit vaccines due to their ability to induce protective immunity. Of the various strategies used for the generation of live attenuated vaccine strains, focus has gradually shifted towards manipulation of virulence regulator genes. Hfq is a RNA chaperon which mediates the binding of small RNAs to the mRNA and assists in post-transcriptional gene regulation in bacteria. In this study, we evaluated the efficacy of the Salmonella Typhimurium Δhfq strain as a candidate for live oral vaccine in murine model of typhoid fever. Salmonella hfq deletion mutant is highly attenuated in cell culture and animal model implying a significant role of Hfq in bacterial virulence. Oral immunization with the Salmonella hfq deletion mutant efficiently protects mice against subsequent oral challenge with virulent strain of Salmonella Typhimurium. Moreover, protection was induced upon both multiple as well as single dose of immunizations. The vaccine strain appears to be safe for use in pregnant mice and the protection is mediated by the increase in the number of CD4+ T lymphocytes upon vaccination. The levels of serum IgG and secretory-IgA in intestinal washes specific to lipopolysaccharide and outer membrane protein were significantly increased upon vaccination. Furthermore, hfq deletion mutant showed enhanced antigen presentation by dendritic cells compared to the wild type strain. Taken together, the studies in murine immunization model suggest that the Salmonella hfq deletion mutant can be a novel live oral vaccine candidate

Ovarian cancer molecular pathology.

Peer reviewe

/STRU^NI RAD UDK 616.65-006.04-097-089 Stage T2 Prostate Cancer Presented with High Serum Prostate Specific Antigen and Nonspecific Bone

Objective: To present the case of T2 prostate cancer (PCa) mimicking disseminated PCa that was successfully treated with radical retropubic prostatectomy (RRP). Patient and the method: The patient had prostate specific antigen (PSA) level higher than 30ng/ml and multiple atypical lesions on bone scan. TRUSguided biopsy proved small PCa, only in 1/18 biopsy cores, with Gleason grade 6 (3+3). Bone lesions appeared to be posttraumatic. Result: The patient underwent RRP; six months after surgery there is no evidence of the disease. Conclusion: Serum PSA level is the sum of cancer activity, normal and BHP tissue production, as well as the result of other pathological conditions, like prostatitis. In some cases, inflammation can be responsible for high PSA level and over-staging. Key words: prostate, cancer, PSA rezim

A double-blind, randomized, controlled trial of topical polysporin triple compound versus topical mupirocin for the eradication of colonization with methicillin-resistant Staphylococcus aureus in a complex continuing care population

BACKGROUND: Intranasal mupirocin or Polysporin Triple (PT) ointment (polymyxin B, bacitracin, gramicidin), in combination with chlorhexidine body washes, have been used for eradicating methicillin-resistant Staphylococcus aureus (MRSA), but no comparative studies have been done