377 research outputs found

    ASURVEY ON CLUSTER BASED LOAD BALANCINGAPPROACHESFOR WIRELESSSENSOR NETWORK

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    Wireless sensor network (WSN) is becoming a very interesting field of research in recent days. It has wide area of research due to various issues caused by the hardware capabilities of sensing nodes such as memory, power, and computing capabilities. One of the major issues is to concentrate on the energy consumption of the sensing node which determines the lifetime of the network. One of such problem is called Hot-spot problem, in which the best channel to the sink are overloaded with traffic and thus causing the nodes to deplete their energy quicker than the energy of other nodes in the network. Clustering algorithms along with sink mobility widely support for equal distribution of the load in the network. In order to overcome this problem various load balancing algorithms are discussed for improving the lifetime of the network

    Structure models for the hydrated and dehydrated nitrate-intercalated layered double hydroxide of Li and Al

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    Imbibition of LiNO3 into gibbsite results in the formation of a single phase layered double hydroxide of the composition LiAl2(OH)6(NO3)·1.2H2O. This phase undergoes reversible dehydration along with the compression of the basal spacing accompanied by the reorientation of the nitrate in the interlayer gallery. The hydrated phase is a solid solution of two lattices: (i) a hexagonal lattice defining the ordering of atoms within the metal hydroxide layer, and (ii) a lattice of orthorhombic symmetry defining the ordering of atoms within the interlayer. DFT calculations of the hydration behaviour show that there is no registry between the two sublattices. In the dehydrated phase, the nitrate ion is intercalated with its molecular plane parallel to the metal hydroxide layer and the crystal adopts a structure of hexagonal symmetry

    Oral immunotherapy for food allergy in children: is it worth it?

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    Introduction: Oral immunotherapy (OIT) is effective at inducing desensitization in food-allergic individuals, and is a valid therapeutic option for those allergic to peanut, cow’s milk and egg. However, there is a high rate of dose-related adverse events, and at least one fatality to OIT has been reported. Areas covered: We provide an update on the broader framework of issues which will impact on the availability and uptake of OIT. Expert opinion: The need for standardized products remains controversial. A licensed product exists for peanut-OIT, but OIT can also be safely achieved using peanut-containing foods at much lower cost. For other allergens, OIT can only be done with non-pharma products – something which has been done safely for over 2 decades. There is a need to develop personalized protocols for OIT, particularly for the 20% of patients unable to tolerate standard OIT. Cost-effectiveness is dependent on improved quality of life, but evidence for this is currently lacking, and is a key evidence gap. OIT is likely to be cost-effective, particularly if noncommercial products are used. There may be a trade-off: in patients with lower reaction thresholds, a commercial product may be needed for initial updosing, until a level of desensitization is achieved when they can be switched to natural food products

    Evaluation of canal orifice inter-relationship and co-relation to occlusal morphology in human permanent mandibular first molar teeth: A In-Vitro study

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    INTRODUCTION: Successful treatment outcomes of endodontic therapy is consistently achievable by adequate awareness of anatomy of the root canal and its relationship to the morphology of the root and surrounding structures. The complexities of the root canal system have been analysed by various researchers as the clinician needs a clear and precise perspective of the presenting canal anatomy. AIM OF THE STUDY: The purpose of this study was to evaluate the interrelationship of orifices and correlate the landmarks on the occlusal surface in the human permanent mandibular first molar teeth. MATERIALS AND METHODS: A total of 314 extracted permanent human mandibular first molar teeth were used. Group L consisted of 155 molars and Group R consisted of 159 molars. Cupal tip of each tooth was marked and occlusal imaging done. All samples were sectioned at the level of the cementoenamel junction using a diamond saw with water coolant. The samples were then placed on the same custom sample placement block and the imaging procedure done using the customized jig setup with the same reference markers, used for the occlusal imaging process. All the samples were analyzed under a operating microscope under 12.8x magnification. The pulp chamber floor was searched for root canal orifice. The observations were recorded. The various angles between the orifices were also calculated using, an image analysis software. The set of angle relationshipsbetween the orifices mesiobuccal, mesiolingual, distal and distolingual were calculated and recorded. The cusp tip to orifice distances, inter cuspal distances were calculated using an image analysis software and the results recorded. The final images of the pulp chamber floor with orifices were analysed after superimposition with the occlusal image by a stacking process using a image processing software and Further a frequency distribution map was also generated RESULTS: Results shows that teeth with single distal orifices were (69.40%), Two distal orifices (26.10%), Disto-lingual orifices (4.40%) and Angles A(19.1), B(21.3), C(40.1), D(65.4), E(72.7), F(20.81), G(21.16), H(62.85 ), I(66.83), J(85.98), K(25.79),L( 106.27). Distances a (1.93mm), b (2.0mm), c (3.05 mm), d (3.16 mm), e (2.05 mm), f (1.98 mm),g (2.40 mm), h (2.19 mm), i (1.22 mm).The mesiobuccal orifice was located closest to the mesiobuccal cusp tip at 1.93 mm distally, towards the mesio-distal midline, the mesiolingual orifice was located closest to the lingual cusp tip at 2.00 mm distally, towards the mesio-distal midline, the distal orifice was located from the disto-buccal cusp tip at 3.00 mm towards the mesio-distal midline and distolingual cusp tip at 3.16 mm onwards the mesio-distal midline with a slight distal tilt and the cusp tips could be used as a constant reference point for location of the orifices and designing access preparation. CONCLUSIONS: Based on the results of the analysis, the orifices were fairly consistently located in relation to each other, irrespective of the size or the position of the tooth. The angles and distances were fairly symmetrical for the L and R groups which confirms the concept of quantifiable pulpal floor morphology

    Comparison of HCHCr Steel and Carbide Punch and Die Increase its Strength and Life by Tin & Ceramics coating

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    Abstract The tools used in the Blanking process are subjected to heav

    Decellularization reduces the immune response to aortic valve allografts in the rat

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    ObjectivesCryopreserved valve allografts used in congenital cardiac surgery are associated with a significant cellular and humoral immune response. This might be reduced by removal of antigenic cellular elements (decellularization). The aim of this study was to determine the immunologic effect of decellularization in a rat allograft valve model.MethodsBrown Norway and Lewis rat aortic valves were decellularized with a series of hypotonic and hypertonic buffers, protease inhibitors, gentle detergents (Triton X-100), and phosphate-buffered saline. Valves were implanted into Lewis rats in syngeneic and allogeneic combinations. Cellular (CD3 and CD8) infiltrates were assessed with morphometric analysis, and the humoral response was assessed with flow cytometry.ResultsMorphometric analysis identified a significant reduction in CD3+ cell infiltrates (cells per square millimeter of leaflet tissue) in decellularized allografts compared with that seen in nondecellularized allografts at 1 (79 ± 29 vs 3310 ± 223, P < .001), 2 (26 ± 11 vs 109 ± 20, P = .004), and 4 weeks (283 ± 122 vs 984 ± 145, P < .001). Anti-CD8 staining confirmed the majority of infiltrates were cytotoxic T cells. Flow cytometric mean channel fluorescence intensity identified a negative shift (abrogated antibody formation) for decellularized allografts compared with nondecellularized allografts at 2 (19 ± 1 vs 27 ± 3, P = .033), 4 (35 ± 2 vs 133 ± 29, P = .001), and 16 weeks (28 ± 2 vs 166 ± 54, P = .017).ConclusionsDecellularization significantly reduces the cellular and humoral immune response to allograft tissue. This could prolong the durability of valve allografts and might prevent immunologic sensitization of allograft recipients

    β3-Adrenoceptor Antagonist SR59230A Attenuates the Imbalance of Systemic and Myocardial Oxygen Transport Induced by Dopamine in Newborn Lambs

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    Background In neonates, the increase in O 2 -delivery (DO 2 ) by dopamine is offset by a greater increase in O 2 -consumption (VO 2 ). This has been attributed to β 3 -adrenergic receptors in neonatal brown fat tissue. β 3 receptors in the heart have negative inotropic properties. We evaluated the effects of SR59230A, a β 3 -antagonist, on the balance of systemic and myocardial O 2 -transport in newborn lambs treated with dopamine. Methods Lambs (2-5 days old, n = 12) were anesthetized and mechanically ventilated. Heart rate (HR) and rectal temperature were monitored. VO 2 was measured by respiratory mass spectrometry and cardiac output (CO) by a pulmonary artery transonic flowmeter. Arterial, jugular bulb venous and coronary sinus blood gases and lactate were measured to calculate DO 2 , O 2 extraction ratio (ERO 2 ), myocardial O 2 and lactate extraction ratios (mERO 2 , mERlac). After baseline measurements, lambs were randomized to receive SR59230A at 5 mg/kg iv (SRG) or placebo. Both groups received incremental doses of a dopamine infusion (0-5-10-15-20 mcg/kg/min) every 15 min. Measurements were repeated at the end of each dose. Results After SR59230A infusion, CO and HR trended to decrease ( P = 0.06), but no significant changes occurred in other parameters. Over the incremental doses of dopamine, temperature increased in both groups ( P 0.1). DO 2 trended to a small increase ( P = 0.08). VO 2 increased in both groups ( P < 0.0001) but to a lesser degree in SRG ( P < 0.0001). As a result, ERO 2 increased in both groups ( P < 0.0001), but to a lesser degree in SRG ( P < 0.0001). mERO 2 was lower in SRG ( P = 0.01) with a faster increase ( P < 0.0001). mERlac was higher in SRG ( P = 0.06) with a faster decrease ( P = 0.04). Conclusion Although SR59230A tends to induce an initial drop in CO, it significantly attenuates the rise in VO 2 and hence the imbalance of systemic and myocardial O 2 transport induced by dopamine at higher doses. Studies are warranted to examine the effect of SR59230A in cases of cardiac dysfunction and increased VO 2 , observed after cardiac surgery
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