43,822 research outputs found

    Fabrication of metal matrix composites under intensive shearing

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    Current processing methods for metal matrix composites (MMC) often produces agglomerated reinforced particles in the ductile matrix and also form unwanted brittle secondary phases due to chemical reaction between matrix and the reinforcement. As a result they exhibit extremely low ductility. In addition to the low ductility, the current processing methods are not economical for producing engineering components. In this paper we demonstrate that these problems can be solved to a certain extent by a novel rheo-process. The key step in this process is application of sufficient shear stress on particulate clusters embedded in liquid metal to overcome the average cohesive force of the clusters. Very high shear stress can be achieved by using the specially designed twin-screw machine, developed at Brunel University, in which the liquid undergoes high shear stress and high intensity of turbulence. Experiments with Al alloys and SiC reinforcement reveal that, under high shear stress and turbulence conditions Al liquid penetrates into the clusters and disperse the individual particle within the cluster, thus leading to a uniform microstructure

    Generation of Test Vectors for Sequential Cell Verification

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    For Application Specific Integrated Circuits (ASIC) and System-on-Chip (SOC) designs, Cell - Based Design (CBD) is the most prevalent practice as it guarantees a shorter design cycle, minimizes errors and is easier to maintain. In modern ASIC design, standard cell methodology is practiced with sizable libraries of cells, each containing multiple implementations of the same logic functionality, in order to give the designer differing options based on area, speed or power consumption. For such library cells, thorough verification of functionality and timing is crucial for the overall success of the chip, as even a small error can prove fatal due to the repeated use of the cell in the design. Both formal and simulation based methods are being used in the industry for cell verification. We propose a method using the latter approach that generates an optimized set of test vectors for verification of sequential cells, which are guaranteed to give complete Single Input Change transition coverage with minimal redundancy. Knowledge of the cell functionality by means of the State Table is the only prerequisite of this procedure

    Changes in murine anorectum signaling across the life course

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    Background: Increasing age is associated with an increase in the incidence of chronic constipation and fecal impaction. The contribution of the natural aging process to these conditions is not fully understood. This study examined the effects of increasing age on the function of the murine anorectum.Methods: The effects of increasing age on cholinergic, nitrergic, and purinergic signaling pathways in the murine anorectum were examined using classical organ bath assays to examine tissue function and electrochemical sensing to determine age‐related changes in nitric oxide and acetylcholine release.Key Results: Nitrergic relaxation increased between 3 and 6 months, peaked at 12 months and declined in the 18 and 24 months groups. These changes were in part explained by an age‐related decrease in nitric oxide (NO) release. Cholinergic signaling was maintained with age by an increase in acetylcholine (ACh) release and a compensatory decrease in cholinesterase activity. Age‐related changes in purinergic relaxation were qualitatively similar to nitrergic relaxation although the relaxations were much smaller. Increasing age did not alter the response of the anorectum smooth muscle to exogenously applied ACh, ATP, sodium nitroprusside or KCl. Similarly, there was no change in basal tension developed by the anorectum.Conclusions and Inferences: The decrease in nitrergic signaling with increasing age may contribute to the age‐related fecal impaction and constipation previously described in this model by partially obstructing defecation

    How should we evaluate the cost-effectiveness of CAR T-cell therapies?

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