78 research outputs found

    Post-Concussion Cognitive Declines and Symptomatology Are Not Related to Concussion Biomechanics in High School Football Players

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    Concussion is a major public health concern with nearly 4 million injuries occurring each year in the United States. In the acute post-injury stage, concussed individuals demonstrate cognitive function and motor control declines as well as reporting increased symptoms. Researchers have hypothesized that the severity of these impairments is related to impact magnitude. Using the Head Impact Telemetry System (HITS) to record head impact biomechanics, we sought to correlate pre- and post-concussive impact characteristics with declines in cognitive performance and increases in concussion-related symptoms. Over four seasons, 19 high school football athletes wearing instrumented helmets sustained 20 diagnosed concussions. Each athlete completed a baseline computer-based symptom and cognitive assessment during the pre-season and a post-injury assessment within 24-h of injury. Correlational analyses identified no significant relationships between symptoms and cognitive performance change scores and impact biomechanics (i.e., time from session start until injury, time from the previous impact, peak linear acceleration, peak rotational acceleration, and HIT severity profile [HITsp]). Nor were there any significant relationships between change scores and the number of impacts, cumulative linear acceleration, cumulative rotational acceleration, or cumulative HITsp values associated with all impacts prior to or following the injury. This investigation is the first to examine the relationship between concussion impact characteristics, including cumulative impact profiles, and post-morbid outcomes in high school athletes. There appears to be no association between head impact biomechanics and post-concussive outcomes. As such, the use of biomechanical variables to predict injury severity does not appear feasible at this time.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90455/1/neu-2E2011-2E1905.pd

    High temperature optical absorption investigation into the electronic transitions in solā€“gel derived C12A7 thin films

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    Optical absorption into 6Ā mm thick solā€“gel derived films, annealed at 1300Ā Ā°C of 12CaOĀ·7Al2O3 calcium aluminate binary compound on MgO怈100怉 single crystal substrates was studied at temperatures ranging from room temperature to 300Ā Ā°C. Experimental data were analysed in both Tauc and Urbach regions. The optical band gap decreased from 4.088Ā eV at 25Ā Ā°C to 4.051Ā eV at 300Ā Ā°C, while Urbach energy increased from 0.191Ā eV at 25Ā Ā°C to 0.257Ā eV at 300Ā Ā°C. The relationship between the optical band gap and the Urbach energy at different temperatures showed an almost linear relationship from which the theoretical values of 4.156 and 0.065Ā eV were evaluated for the band gap energy and Urbach energy of a 12CaOĀ·7Al2O3 crystal with zero structural disorder at 0Ā K

    Hyponatremia in the intensive care unit: How to avoid a Zugzwang situation?

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    Magnesium Deficiency and Diabetes

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    Time-restricted feeding improves glucose tolerance in men at risk for type 2 diabetes: a randomized crossover trial

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    Objective: This study aimed to assess the effects of 9-hour time-restricted feeding (TRF), early (TRFe) or delayed (TRFd), on glucose tolerance in men at risk for type 2 diabetes. Methods: Fifteen men (age 55 Ā± 3 years, BMI 33.9 Ā± 0.8 kg/mĀ² ) wore a continuous glucose monitor for 7 days of baseline assessment and during two 7-day TRF conditions. Participants were randomized to TRFe (8 am to 5 pm) or TRFd (12 pm to 9 pm), separated by a 2-week washout phase. Glucose, insulin, triglycerides, nonesterified fatty acids, and gastrointestinal hormone incremental areas under the curve were calculated following a standard meal on days 0 and 7 at 8 am (TRFe) or 12 pm (TRFd). Results: TRF improved glucose tolerance as assessed by a reduction in glucose incremental area under the curve (P = 0.001) and fasting triglycerides (P = 0.003) on day 7 versus day 0. However, there were no mealtime by TRF interactions in any of the variables examined. There was also no effect of TRF on fasting and postprandial insulin, nonesterified fatty acids, or gastrointestinal hormones. Mean fasting glucose by continuous glucose monitor was lower in TRFe (P = 0.02) but not TRFd (P = 0.17) versus baseline, but there was no difference between TRF conditions. Conclusions: While only TRFe lowered mean fasting glucose, TRF improved glycemic responses to a test meal in men at risk for type 2 diabetes regardless of the clock time that TRF was initiated.Amy T. Hutchison, Prashant Regmi, Emily N.C. Manoogian, Jason G. Fleischer, Gary A. Wittert, Satchidananda Panda, and Leonie K. Heilbron
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