Feeling Unsafe at School: Southeast Asian American Adolescents’ Perceptions and Experiences of School Safety

School safety impacts mental health and educational attainment particularly among vulnerable populations such as refugee youth. Using data from the Children of Immigrants Longitudinal Study (CILS), this study examined the mental health impact of perceptions and experiences that compromise school safety among Southeast Asian American adolescents (N = 645). Higher rates of perceptions and experiences that violated students’ feelings of safety at school were associated with decreased self-esteem and increased levels of depressive symptoms. Hierarchical regressions indicate that in light of perceptions and experiences of feeling unsafe at school, bicultural orientation, importance of identity, and family cohesion have an additive effect in predicting self-esteem and family cohesion has an additive effect with depressive symptoms though no moderation effects were found

Laser cleaning of diagnostic mirrors from tokamak-like carbon contaminants

This paper presents a laboratory-scale experimental investigation of laser cleaning of diagnostic First Mirrors (FMs). Redeposition of contaminants sputtered from tokamak first wall onto FMs surface could dramatically decrease their reflectivity in an unacceptable way for the functioning of the plasma diagnostic systems. Laser cleaning is a promising solution to tackle this issue. In this work, pulsed laser deposition was exploited to produce rhodium films functional as FMs and to deposit onto them carbon contaminants with tailored features, resembling those found in tokamaks. The same laser system was also used to perform laser cleaning experiments by means of a sample handling procedure that allows to clean some cm(2) in few minutes. The cleaning effectiveness was evaluated in terms of specular reflectivity recovery and mirror surface integrity. The effect of different laser wavelengths (lambda = 1064, 266 nm) on the cleaning process is also addressed

Combination of ozone and activated carbon for Pharmaceuticals and Personal Care Products (PPCPs) removal in drinking water: influence of compounds characteristics and organic matter competition

The presence of Pharmaceuticals and Personal Care Products (PPCPs) in drinking water is raising concern for potential negative effects on human health. Ozonation and adsorption on activated carbon (AC) are the most promising processes for PPCPs removal among those usually present in drinking water treatment plants (DWTPs). To evaluate the performance of these processes, both individually and in combination, adsorption isotherms were determined on real matrices collected in a DWTP before and after ozonation, focusing on 10 PPCPs identified as the most critical for the analysed DWTP. AC showed higher PPCPs removals than ozonation, but the combination of the two processes was beneficial. However, the effect of ozone on adsorption depends on PPCPs reactivity with ozone. A competitive effect of organic matter on PPCPs adsorption was observed. Finally, the removal of absorbance at 254 nm is a good proxy variable for PPCPs removal

First case of typhoid fever due to extensively drug-resistant Salmonella enterica serovar typhi in Italy

Typhoid fever is a potentially severe and occasionally life-threatening bacteraemic illness caused by Salmonella enterica serovar Typhi (S. Typhi). In Pakistan, an outbreak of extensively drug-resistant (XDR) S. Typhi cases began in November 2016. We report on a five-year-old boy who contracted enteric fever while travelling in Pakistan and was diagnosed after returning to Italy in September 2019. Blood culture isolated Salmonella enterica serovar Typhi that was XDR to all first-line antibiotics, including ceftriaxone and fluoroquinolones. Empiric therapy was switched to meropenem, and the patient recovered completely. Whole-genome sequencing showed that this isolate was of haplotype H58. The XDR S. Typhi clone encoded a chromosomally located resistance region and harbored a plasmid encoding additional resistance elements, including the blaCTX-M-15 extended-spectrum β-lactamase and the qnrS fluoroquinolone resistance gene. This is the first case of typhoid fever due to XDR S. Typhi detected in Italy and one of the first paediatric cases reported outside Pakistan, highlighting the need to be vigilant for future cases. While new vaccines against typhoid are in development, clinicians should consider adapting their empiric approach for patients returning from regions at risk of XDR S. Typhi outbreak with typhoid symptoms

Fate of Pharmaceuticals and Personal Care Products (PPCPs) from discharge to drinking water: a modelling and monitoring integrated framework

Pharmaceuticals and Personal Care Products (PPCPs) presence in drinking water is gaining growing concern for potential negative effects on human health. This study combined modelling of river transport with monitoring campaigns performed over one year at a drinking water treatment plant (DWTP) located at the closure section of Po river basin, to evaluate the types of released PPCPs, their concentrations and fate in both the river and the DWTP. Over the 114 monitored PPCPs, maximum 23 compounds have been detected at the DWTP inlet with concentrations from 10 to 1800 ng/L, varying among PPCPs and in time. The transport in Po river of iopamidol, with the highest concentration at the DWTP inlet, was simulated combining hydrological and quality data and models. Finally, DWTP monitoring showed that ozonation and adsorption onto activated carbon have the main impact in reducing a wide variety of PPCPs, with performances influenced by their characteristics

BubR1 promotes Bub3-dependent APC/C inhibition during Spindle Assembly Checkpoint signaling.

The spindle assembly checkpoint (SAC) prevents premature sister chromatid separation during mitosis. Phosphorylation of unattached kinetochores by the Mps1 kinase promotes recruitment of SAC machinery that catalyzes assembly of the SAC effector mitotic checkpoint complex (MCC). The SAC protein Bub3 is a phospho-amino acid adaptor that forms structurally related stable complexes with functionally distinct paralogs named Bub1 and BubR1. A short motif ("loop") of Bub1, but not the equivalent loop of BubR1, enhances binding of Bub3 to kinetochore phospho-targets. Here, we asked whether the BubR1 loop directs Bub3 to different phospho-targets. The BubR1 loop is essential for SAC function and cannot be removed or replaced with the Bub1 loop. BubR1 loop mutants bind Bub3 and are normally incorporated in MCC in vitro but have reduced ability to inhibit the MCC target anaphase-promoting complex (APC/C), suggesting that BubR1:Bub3 recognition and inhibition of APC/C requires phosphorylation. Thus, small sequence differences in Bub1 and BubR1 direct Bub3 to different phosphorylated targets in the SAC signaling cascade

Uso secundario de una historia clínica digital para el análisis de las reinternaciones en un hospital de la comunidad en Argentina

En el marco del desarrollo de la historia clínica informatizada de internación, se aprovechó la estructura generada para realizar un diagnóstico de las reinternaciones del 2014 de todos los pacientes que ingresaron al Hospital Alemán. Los objetivos fueron cuantificar y analizar las reinternaciones en los 30 días posteriores al alta y estimar las tasas específicas por servicio y diagnóstico. Es un estudio exploratorio descriptivo, se utilizaron como fuente primaria de datos las historias clínicas informatizadas de las internaciones del 2014 en el Hospital Alemán. Para definir su carácter de reinternación se tuvieron en cuenta todas las internaciones posteriores a un alta dentro de los 30 días siguientes a la primera. Para comparar los resultados se analizaron los subgrupos de reinternados por diagnóstico igual o similar, denominando a estas reinternaciones como específicas. Para el cálculo de las tasas por diagnóstico se tuvo en cuenta la codificación mediante CIE9 CM. De 11602 internaciones, se identificaron 1232 (11,16%) como reinternaciones brutas y 337 (3,05%) como reinternaciones específicas. Se hizo hincapié en los análisis de las reinternaciones que tuvieron el mismo diagnóstico o similar. La mediana de edad fue 60 años, el 50,30% fueron en hombres. La reinternación resultó más frecuente en los grupos etarios de más de 40 años. Los servicios que más reinternaron fueron clínica médica, urología, pediatría, cirugía general y cardiología. De acuerdo al tipo de internación más de la mitad de las reinternaciones fueron clínicas. Los diagnósticos de mayor frecuencia fueron cálculo en uréter, enfermedad pulmonar obstructiva crónica, neumonía, embarazo y cólico en riñón; conformando un 9,5% las causas relacionadas con litiasis en el tracto urinario, 7,4% las de origen respiratorio, 7,7% las de origen cardiovascular y 2,1% las relacionadas con traumatismos de cadera/rodilla. Las tasas de reinternación más altas correspondieron a los diagnósticos de colangitis, obstrucción conducto biliar, neumonitis por aspiración, enfermedad pulmonar obstructiva crónica, y cálculo en vía urinaria (>14%). Si bien las tasas de reinternación específicas fueron menores a la bibliografía consultada, se aproximaron al orden de frecuencia y relevancia, permitiendo afirmar que su uso detecta las causas en forma más coherente y ajustada a cada caso en particular. Asimismo, la reinternación se mostró asociada al sexo, a la edad de egreso de los pacientes, a la duración en días de internación, a los intervalos en días comprendidos entre el alta y la reinternación, y a las internaciones de tipo quirúrgicas. Se supone esta primera fase exploratoria como relevante para generar nuevas formas de abordaje para la construcción de modelos de predicción que permitan establecer los riesgos de reinternación en nuestro hospital y de esta manera establecer mecanismos de prevención apropiados.Sociedad Argentina de Informática e Investigación Operativa (SADIO

Locked-in syndrome after basilary artery thrombosis by mucormycosis masquerading as meningoencephalitis in a lymphoma patient

Locked-in syndrome is a rare clinical syndrome due to basilary artery thrombosis generally associated with trauma, vascular, or cardiac malformation. It can present as various types of clinical evolution and occasionally masquerades as other pathological conditions, such as infective meningoencephalitis. These complications are the cause of diagnostic delay, if not promptly recognised, followed by patient death. We report the case of a 42-year-old female with a systemic B and cutaneous T-cell non-Hodgkin\u2019s lymphoma, with a severe neutropenia lasting over a year, who eventually developed a rapid and fatal fungal mucormycosis sepsis following a skin infection on her right arm, associated with locked-in syndrome and meningoencephalitis