Spleen tyrosine kinase/FMS-Like tyrosine kinase-3 inhibition in relapsed/refractory B-cell lymphoma, including diffuse large B-cell lymphoma: updated data with mivavotinib (TAK-659/ CB-659

We report an updated analysis from a phase I study of the spleen tyrosine kinase (SYK) and FMS-Like tyrosine kinase 3 inhibitor mivavotinib, presenting data for the overall cohort of lymphoma patients, and the subgroup of patients with diffuse large B-cell lymphoma (DLBCL; including an expanded cohort not included in the initial report). Patients with relapsed/refractory lymphoma for which no standard treatment was available received mivavotinib 60–120 mg once daily in 28-day cycles until disease progression/unacceptable toxicity. A total of 124 patients with lymphoma, including 89 with DLBCL, were enrolled. Overall response rates (ORR) in response-evaluable patients were 45% (43/95) and 38% (26/69), respectively. Median duration of response was 28.1 months overall and not reached in DLBCL responders. In subgroups with DLBCL of germinal center B-cell (GCB) and non-GCB origin, ORR was 28% (11/40) and 58% (7/12), respectively. Median progression free survival was 2.0 and 1.6 months in the lymphoma and DLBCL cohorts, respectively. Grade ≥3 treatment-emergent adverse events occurred in 96% of all lymphoma patients, many of which were limited to asymptomatic laboratory abnormalities; the most common were increased amylase (29%), neutropenia (27%), and hypophosphatemia (26%). These findings support SYK as a potential therapeutic target for the treatment of patients with B-cell lymphomas, including DLBCL

Color-Tunable Eu(3+) and Tb(3+) co-doped nanophosphors synthesis by plasma-assisted method

With increasing health consciousness, Y₂O₃‐based rare earth nanophosphors are considered as promising luminescent complexes for bio‐applications. In the present study, an atmospheric pressure plasma‐electrochemical technique is demonstrated for the synthesis of Eu³⁺/Tb³⁺ single‐doped or co‐doped Y₂O₃ nanophosphors from merely an aqueous solution of the corresponding rare earth nitrite salts. Systematic experiments were performed to prepare (Y₁‐x‐yEuxTby)₂O₃ nanophosphors of various Tb³⁺ and Eu³⁺ ratios (x:y = 1:0, 2:1, 1:1, 1:2, and 0:1), with the ultimate goal to achieve the colour tunability by simply adjusting the dopant compositions. Results indicated successfulness synthesis of crystalline Eu/Tb single‐doped and co‐doped Y₂O₃ nanophosphors with Tb³⁺ and Eu³⁺ ions being uniformly incorporated into the Y₂O₃ host matrix. The generated products showed apparent downshift behaviour under ultraviolet irradiation, and characteristic spectral excitation and emission bands were detected by the photoluminescence measurement. Furthermore, by adjusting the relative composition ratios of the terbium and europium ions, the emission colours were shown to be regulated to a large extent. The demonstrated process can be characterized as simple, versatile and environmentally‐friendly, featuring great flexibility in colour tunability, and therefore can present a considerable interest for emerging nanofabrication applications.LiangLiang Lin, XinTong Ma, Sergey A. Starostin, SiRui Li, Volker Hessel, Jie Shen, ShaoMing Shang, and HuJun X