Salvage antegrade visceral revascularization and antegrade aortic stenting for type I and III endoleaks after fenestrated juxtarenal aneurysm repair

A 73-year-old man developed type I and III endoleaks from a fractured right renal stent with downward migration of a fenestrated endograft, 6 years after endovascular repair of a juxtarenal aneurysm. Endovascular treatment attempts were unsuccessful. He underwent aortic debranching and antegrade visceral artery revascularization via a left thoracolaparotomy incision and an extraperitoneal approach to the visceral aorta. An antegrade aortic stent covered the endoleak, with technical and clinical success at 9 months. Failure of complex endografts presents particular problems, potentially not amenable to totally endovascular repair. Continued surveillance is mandated as late, asymptomatic sac expansion can occur

Producción, caracterización y actividad anticancerígena de soforolípidos producidos mediante fermentación en estado sólido con Candida bombicola de tortas de girasol y aceite de soja

The production of sophorolipids by Candida bombicola NRRL Y- 17069 grown in a mixture of sunflower oil cake and crude soybean oil as economic substrates with different fermentation techniques was studied. The highest yield (49.5 g·100 g−1 substrates) was obtained from solid state fermentation after employing a new concept for extraction by methanol (E I) followed by ethyl acetate (E II), then partially purified with hexane (E III). The course of time of fermentation was also studied, and E I extracted of the 12th day showed the minimum surface tension (45 mN·m−1) at a critical micelle dilution (CMD) of 10% concentration. The produced sophorolipids were characterized and confirmed by FTIR and 1H NMR spectroscopy. The anticancer activity of the produced compounds was assessed against MCF-7, HepG2, A549, HCT116 cancer cell lines and the results revealed that E III and E IV (a mixture of E I & E III) act as promising anticancer agents in HepG2 and A549 by inhibiting urokinase and histone deacetylase activities.Se estudió la producción de soforolípidos por Candida bombicola NRRL Y- 17069 cultiva con diferentes técnicas de fermentación en una mezcla de torta de girasol y aceite de soja crudo, como sustratos económicos. El rendimiento más alto (49,5 g·100 g−1 de sustrato) se obtuvo por fermentación en estado sólido después de extraer con metanol (IE) seguido de acetato de etilo (EII), y de purificación parcial con hexano (EIII). También se estudió el tiempo de fermentación, considerando que el extracto IE de 12 días mostró una tensión superficial mínima (45 mN·m−1) a una dilución micelar crítica (CMD) de concentración 10 %. Los soforolípidos producidos se caracterizaron y se confirmaron mediante espectroscopia FTIR y RMN de 1H. La actividad anticancerígena de los compuestos producidos se evaluó en células MCF-7, HepG2, A549, líneas celulares de cáncer de HCT116 y los resultados revelaron que EIII y EIV (una mezcla de EI y EIII) actúan como prometedores agentes anticancerígenos en HepG2 y A549 inhibiendo las actividades de uroquinasa e histona desacetilasa

Diethyl 2-[(4-nitro­phen­yl)(4-phenyl-1,2,3-selenadiazol-5-yl)meth­yl]malonate

In the title compound, C22H21N3O6Se, the heterocyclic ring makes dihedral angles of 50.03 (11) and 67.75 (11)°, respectively, with the benzene and phenyl rings. The terminal C atoms of the ester groups are disordered over two positions: the site occupancies for the C atoms are 0.62 (3)/0.38 (3) and 0.48 (3)/0.52 (3). In the crystal structure, weak intra- and inter­molecular C—H⋯O inter­actions are observed

Ethyl 2-phenyl-3-(4-phenyl-1,2,3-selenadiazol-5-yl)-3-p-tolyl­propano­ate

In the title compound, C26H24N2O2Se, the selenadiazole ring is essentially planar [maximum deviation = 0.004 (3) Å]. The dihedral angle between the selenadiazole ring and the attached benzene ring is 50.17 (1)°. The crystal packing is stabilized by inter­molecular C—H⋯N inter­actions

4-(4-Chloro­phen­yl)-5-[1-(4-chloro­phenyl)-2-methyl-2-nitro­prop­yl]-1,2,3-selenadiazole

In the title compound, C18H15Cl2N3O2Se, the selenadiazole ring makes dihedral angles of 49.87 (3) and 55.70 (3)° with the two benzene rings. The dihedral angle between the two benzene rings is 11.90 (5)°. In the crystal structure, intra­molecular C—H⋯O and C—H⋯Se inter­actions and inter­molecular C—H⋯O, C—H⋯Cl and C—H⋯N inter­actions are observed

Safety culture assessment and its relationship with the personality traits of sports facility managers

Background and aims: Great investments are made in many countries to provide the grounds for every member of the society to be benefited. However, the results of several studies show that many people suffer from multiple injuries and sometimes die as they are doing sports activities. Therefore, sport is one of the high-risk activities with many professional damages that apart from economic costs on the health, include very serious psychological costs on athletes, families in specific and the whole society, in general. Today, it is believed that most of the accidents (about 85 percent) are due to the errors and carelessness of the employees. Therefore, it seems that Improving the safety culture is a basic solution to reduce these accidents in sports events and fields. Safety culture refers to a set of beliefs, motifs, norms, roles and performances that reduce the encounter of employees and managers to dangerous situations. If the governing safety culture in an organization is positive and desirable, this culture, as an effective factor, can commit all elements of the organization to have a major contribution to the safety of themselves and their colleagues. Management is the key element in the safety culture. Management is the key element in safety culture. Managers play a key and essential role in improving the safety culture, preventing accidents and improving job performance and culturalization, and accelerating the process. Among factors affecting occupational performance is the individuals' personality because the individual personality determines his/ her motivation and attitude toward job and the way the individual responds to job requirements. The value of the personality has been accepted as one of the predictors of occupational and behavioral performance. According to the researchers, unsafe behaviors are highly influenced by individuals' personal traits because the individuals' personality traits determine their motifs and attitudes towards their job and how they meet job requirements. Therefore, individuals related to sensitive and safety-related conditions should be highly sensitive to observe safety principles proportionate to their characteristics and consider creating a positive safety culture as an essential issue in sports activities to reduce accidents effectively. Therefore, by identifying and investigating the personality dimensions of sports places managers, it can be used as a predictor of unsafe behaviors. In summary, paying attention to numerous risks in sports activities is essential and taking safety culture into consideration as a major priority is natural is sports. Considering the role and responsibility of sport field managers in safety and health of athletes, spectators and other visitors, the present study aims at evaluating the safety culture among sport field managers based on IAEA Model and its relationship with their Demographic characteristics and personality. This study aims at answering the following questions: first, how is safety culture among sport field managers? Second, what is the relationship between the positive safety culture and Demographic characteristics and personality of sport field managers (gender, being extroverted or introverted, and experience and education level)? Methods: This is an applied study in terms of purpose, a descriptive survey in terms of data collection methodology, and a correlation study in terms of data analysis. The research population includes all the sport field managers in Iran that consists of 22167 participants according to the statistics of the Development and Maintenance of Sports Facilities of Iran. The sample size included 379 participants based on the table of Krejcie and Morgan. Considering the level of errors due to not receiving complete questionnaires (the questionnaires being lost, not answering them, incomplete and invalid questionnaires), a number of 416 questionnaires were distributed and finally, 400 appropriate and flawless questionnaires were collected and analyzed. Multistage sampling was conducted on different provinces and cities and finally, the sample was selected using simple random sampling. The research tools included Eysenck Personality Questionnaire (EPQ) (1968) and demographic variables including 25 questions and the Safety Culture Survey including 35 questions related to the field of learning and teaching, responsibility, safety priorities, leadership and safety integrity. To insure the face and content validity of the questionnaire, its first edition was investigated by the experts in the field and the required corrections were applied on the items according to experts' comments. The questionnaires were used after the experts confirmed them. The questionnaires' reliability was calculated to be 0.76 for the Eysenck Personality Questionnaire and 0.82 for the Safety Culture Survey in a preliminary study by internal consistency through Chronbach's alpha. Descriptive statistics (frequency tables, frequency percentage, average and standard deviation) and inferential statistics (variance analysis, independent T-test, Pearson's correlation coefficient and logistic regression) were used for data analysis using SPSS 19 at the significance level of p > 0.05. Results: Demographic findings of the research showed that the majority of the statistical male sample (68.5) holds bachelor degree (44.5) and master degree (29.5). Results showed that the mean safety culture of sport field managers was 130.12 And its standard deviation was 21.5. The score above 105 is regarded as the positive safety culture. The independent T-test showed that the average score of safety culture is higher in women than men and the difference is significant according to the value of t + -2.970 at the significance level of P = 0.00. Results of ANOVA showed that although by the increase in the work experience, the level of safety culture increases, while no significant relationship was observed between the two variables (P = 0.657). Results of ANOVA showed that by an increase in education level, the positive safety culture increases, while the relationship was not significant statistically (P = 0.391). Eta correlation coefficient showed that there is a significant (P = 0.01) negative (r = - 0.19) relationship between being extroverted and the safety culture. Moreover, there is a significant (P 0.00) and direct (r = 0.29) relationship between being introverted and the safety culture. Considering the type of variables and using eta correlation coefficient to investigate the correlation between the variables, logistic regression was used to determine which variables are strong predictors of safety culture. For overall estimation of the model, omnibus test analysis was used. Omnibus test showed that the logistic regression model was significant. That is, it can predict the variables efficiently. The log-likelihood of logistic regression showed that the variables are 69 percent able to determine the dependent variable. The results of Hosmer-Lemeshow test (HL test) for regression fitting showed that the model is appropriate and fit well. This means that a series of variables have predicted the criterion variable. Therefore, the predictors of safety culture should be identified from among the variables. Results of odds ratio showed that the odd ratio of being introverted and extroverted is relatively good. The odds ratio equals beta (β) in linear regression. The ratio was significant with 0.39 for being extroverted and 0.48 for being introverted. In general, the more extroverted the person is, the safety culture increases and it is vice versa regarding being introverted. In this regard, classification of the average values of safety culture aspects showed that safety priority with an average value of 31.5 and responsibility with an average value of 24.2 had the greatest and smallest average values. Conclusion: Conclusion: The safety culture is an essential element to prevent accidents from occurring in sports places and events. In the view of researchers, the incidence of unsafe behaviors is greatly under the influence of personality traits of individuals, especially managers. Therefore, the current research aims to investigate the relationship between personality traits of sports places' managers and their safety culture. Results showed that the safety culture has a significant relationship with gender, extroversion, and introversion of managers, but has no significant relationship with work experience and education level. It seems that the more positive attitude of women towards occupational issues, psychological and personality traits, higher sensitivity to job safety issues and avoiding risks that makes them attempt to do the assigned tasks in the best way and the least risks, direct more attention to safety culture in women. In addition, unlike the extroverted people who are risk-taking and in search of excitement do not shoulder their responsibilities and believe that accidents are inevitable, the introverted are indecisive, thoughtful and cautious. The introverted believe that events and accidents are results of their actions and are more satisfied with their actions. Since the introverted are conditioned more and quicker, they adapt to the crowd and obey the rules. They pay more attention to the current rules of safety and follow the rules to develop positive safety culture and reduce unsafe actions. Accordingly, the safety culture is higher in the introverted than in the extroverted. Regarding the lack of effect of education level on mangers' safety culture, it can be stated that courses related to safety in PE is not taught in higher education in the field of physical education. Furthermore, during in-service courses, the training courses are held similarly for all the people at different education levels and this leads to the irrelevance of the awareness of managers and employees about safety and education level. Therefore, investigating different aspects of personality and safety culture, the efficiency in sports organizations can be improved and the accidents in sport events and fields can be reduced besides identifying and assigning people that pay less attention to safety culture to low-risk jobs. © 2020 Iran University of Medical Sciences. All rights reserved

Derivation and Validation of an Inâ Hospital Mortality Prediction Model Suitable for Profiling Hospital Performance in Heart Failure

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142499/1/jah32925_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142499/2/jah32925.pd

4-{(4-Chloro­phen­yl)[4-(4-methyl­phen­yl)-1,2,3-selenadiazol-5-yl]meth­yl}-4,5,6,7-tetra­hydro-1,2,3-benzoselenadiazole

In the title compound, C22H19ClN4Se2, the mean plane of the non-fused selenadiazole ring forms dihedral angles of 54.20 (16)° and 70.48 (11)°, respectively, with the essentially planar [maximum deviations of 0.025 (5) and 0.009 (2) Å, respectively] methyl­phenyl and chloro­phenyl substituents. The tetra­hydro-1,2,3-benzoselenadiazole group is disordered over two sets of sites with a refined occupancy ratio of 0.802 (5):0.198 (5). In the crystal, weak inter­molecular C—H⋯N inter­actions are observed