Morphometric characteristics of basal cell carcinoma peritumoral stroma varies among basal cell carcinoma subtypes

<p>Abstract</p> <p>Background</p> <p>The role that the peritumoral stroma plays in the growth of tumours is currently poorly understood. In this manuscript the morphometric characteristics of basal cell carcinoma subtypes and their associated peritumoral stromas are presented.</p> <p>Methods</p> <p>Ninety eight digitized basal cell carcinoma histology slides were categorized as infiltrative, nodular, or superficial subtypes, and were analysed using a combination of manual and computer-assisted approaches. The morphometric characteristics of the tumour nests and their associated peritumoral stroma were quantified, and the presence of a marked immune reaction or elastosis was noted.</p> <p>Results</p> <p>The tumour to stroma ratio was different among each tumour subtype. Elastosis was identified in a greater proportion of the infiltrative tumours.</p> <p>Conclusions</p> <p>Quantitative differences exist between the peritumoral stroma of basal cell carcinoma subtypes. Future work exploring the relation between these morphometric differences and biochemical variations in peritumoral stroma may further our understanding of the biology of carcinoma development.</p> <p>Trial Registration</p> <p>Not applicable.</p

Plasma spraying of boron carbide using ternary gas mixtures

International audienceMaterials which exhibit high specific heat and melting enthalpy combined with a low density, like boron carbide B4C, are difficult to melt by plasma spraying under standard spray conditions. Moreover, the injection of this low-density powder in the plasma jet is critical, especially when fine particles are used. The optimization of the plasma-forming gas composition may make the penetration of the particles in the gas flow easier, and improve their melting state. This paper presents an investigation of the effect of the composition of ternary gas mixtures of argon, helium and hydrogen on B4C particles heating and acceleration. The particle injection and the resulting spray pattern in the jet were controlled by using a 1D imaging technique. The particle velocity distribution was measured with a laser Doppler anemometer and the particle overall temperature with a high-speed pyrometer