Pharmaco-therapy optimization of osteoporosis and osteopenic syndrome in patients with vibratory disease of common and local impact

Vibratory disease is one of the leading pathologies in the field of professional diseases, Polymorphism of manifestation is its peculiarity, including disorders of bone remodelling process. The goal of this study was to define peculiarity of bone interchange in patients with vibratory disease of common and local impact. Material and methods. 272 patients took part in the research; they were subjected to determination of mineral density level of bone tissue, markers of osteosis and bone resorption and cytokine profile. Three variants of treatment were used in the period of 12 months. Results. Positive dynamics of ultrasonic densitometry indices, osteogenesis markers (ionized calcium, alkaline phos-phatase), osteoprotogerine in sub-groups with vibrating disease treated with calcium medication and vitamin D was revealed. Conclusion. Research of mineral density of bone tissue and markers of bone remodelling is necessary for prescription a pathogenetic therapy at osteoporosis and osteopenic syndrome in patients with vibrating disease from general to local impact

The importance of pharmacogenetic research for optimization of antihypertensive treatment

As time goes by, significant individuality of antihypertensive drugs effectiveness may be clarified by pharmacogenetic research methods. Pronounced variability of pharmacological response may be caused by mononucleotide substitutions in genes, coding biotransformation enzymes. The present work is dedicated to investigation of allelic variants of functionally defective genes CYP2D6 and CYP2C9 in patients with arterial hypertension. Possible relation of distinct associations of polymorphous gene variants with difference in individual sensitivity to beta-blockers and angiotensin receptor blockers was shown