3,111 research outputs found

    On the growth rates of human malignant tumors: Implications for medical decision making

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    Extinction correction and on-sky calibration of SCUBA-2

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    Commissioning of SCUBA-2 included a program of skydips and observations of calibration sources intended to be folded into regular observing as standard methods of source flux calibration and to monitor the atmospheric opacity and stability. During commissioning, it was found that these methods could also be utilised to characterise the fundamental instrument response to sky noise and astronomical signals. Novel techniques for analysing on-sky performance and atmospheric conditions are presented, along with results from the calibration observations and skydips.Comment: 10 pages, 7 figure

    Phase transitions and the internal noise structure of nonlinear Schr\"odi nger equation solitons

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    We predict phase-transitions in the quantum noise characteristics of systems described by the quantum nonlinear Schr\"odinger equation, showing them to be related to the solitonic field transition at half the fundamental soliton amplitude. These phase-transitions are robust with respect to Raman noise and scattering losses. We also describe the rich internal quantum noise structure of the solitonic fields in the vicinity of the phase-transition. For optical coherent quantum solitons, this leads to the prediction that eliminating the peak side-band noise due to the electronic nonlinearity of silica fiber by spectral filtering leads to the optimal photon-number noise reduction of a fundamental soliton.Comment: 10 pages, 5 figure

    Transcriptome-wide analysis reveals different categories of response to a standardised immune challenge in a wild rodent

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    Individuals vary in their immune response and, as a result, some are more susceptible to infectious disease than others. Little is known about the nature of this individual variation in natural populations, or which components of immune pathways are most responsible, but defining this underlying landscape of variation is an essential first step to understanding the drivers of this variation and, ultimately, predicting the outcome of infection. We describe transcriptome-wide variation in response to a standardised immune challenge in wild field voles. We find that markers can be categorised into a limited number of types. For the majority of markers, the response of an individual is dependent on its baseline expression level, with significant enrichment in this category for conventional immune pathways. Another, moderately sized, category contains markers for which the responses of different individuals are also variable but independent of their baseline expression levels. This category lacks any enrichment for conventional immune pathways. We further identify markers which display particularly high individual variability in response, and could be used as markers of immune response in larger studies. Our work shows how a standardised challenge performed on a natural population can reveal the patterns of natural variation in immune response

    Effect of backscattering in phase conjugation with weak scatterers

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    An extension is presented of a recently developed theory (based on the first Born approximation) of cancellation of distortions by phase conjugation. The influence of backscattering of both the incident and the conjugate waves is considered. It is shown that, when backscattering is taken into account, distortions are not eliminated by phase conjugation, except when the conjugate wave is generated without a loss or a gain

    Scattering theory of distortion correction by phase conjugation

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    The correction of wave distortions by the technique of optical phase conjugation is examined first on the basis of a newly derived integral equation for scattering of monochromatic scalar waves in the presence of a phase-conjugate mirror. The solution is developed in an iterative series, and the first- and second-order terms are analyzed and illustrated diagrammatically. A generalization of the integral equation is then presented, which takes into account the electromagnetic nature of light. It is also shown that, if the conjugate wave is generated without losses or gains and with a complete reversal of polarization, a total elimination of distortions may be achieved by this technique under circumstances that frequently occur in practice
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