The Lysosome and Intracellular Signalling.

In addition to being the terminal degradative compartment of the cell's endocytic and autophagic pathways, the lysosome is a multifunctional signalling hub integrating the cell's response to nutrient status and growth factor/hormone signalling. The cytosolic surface of the limiting membrane of the lysosome is the site of activation of the multiprotein complex mammalian target of rapamycin complex 1 (mTORC1), which phosphorylates numerous cell growth-related substrates, including transcription factor EB (TFEB). Under conditions in which mTORC1 is inhibited including starvation, TFEB becomes dephosphorylated and translocates to the nucleus where it functions as a master regulator of lysosome biogenesis. The signalling role of lysosomes is not limited to this pathway. They act as an intracellular Ca2+ store, which can release Ca2+ into the cytosol for both local effects on membrane fusion and pleiotropic effects within the cell. The relationship and crosstalk between the lysosomal and endoplasmic reticulum (ER) Ca2+ stores play a role in shaping intracellular Ca2+ signalling. Lysosomes also perform other signalling functions, which are discussed. Current views of the lysosomal compartment recognize its dynamic nature. It includes endolysosomes, autolysosome and storage lysosomes that are constantly engaged in fusion/fission events and lysosome regeneration. How signalling is affected by individual lysosomal organelles being at different stages of these processes and/or at different sites within the cell is poorly understood, but is discussed

An Shigao

This second volume of Brilland#39;s Encyclopedia of Buddhism, devoted to Lives, offers a wide array of entries devoted both to the Buddhist pantheon and to historical Buddhists from throughout Asia in the pre-modern period

Religious pluralism and processes of individualisation in Hinduism

The paper explores the interconnection between religious pluralisation and processes of individualisation in India by focusing on the emergence of religious alternatives to Vedic ritualism in the centuries around the beginning of the Common Era. Criticism of established religious goals and practices voiced by individuals was accompanied by an increasing interest in the structures of individual existence. The conceptualisation of the individual in the philosophical and religious literature of the period is an important aspect of establishing new religious pathways with ideas of self, agency and personal relatedness being of central concern. On the basis of different doctrines religious options gained acceptance which allow individuals to pursue their religious aspirations either apart from or parallel to the ritual-social obligations in the context of caste-hierarchy. The new religious options gravitate towards institutionalisation in the form of religious communities (sampradāya). These are not only important elements in organising Hindu religious pluralism, but also allow for recurrent processes of religious individualisation