A systematic review on animal models of maternal high fat feeding and offspring glycaemic control

The mechanistic link between obese parents and obese offspring and the relative role of genes, and a shared environment is not completely understood. Animal models help us to differentiate between genetic and environmental factors, and the interaction between the two. However, the willingness of researchers to blend results from multiple models makes it difficult for clear mechanisms to be identified for specific hypothesis-driven research. As such we conducted a systematic review of animal models of maternal high fat feeding in an effort to identify the affect on the offspring glycaemic control. Maternal and offspring outcomes are reported in an effort to identify possible relationships to facilitate and focus on future research. We present here data from 11 studies investigating glycaemic control in offspring exposed to a high fat diet (HFD) during maternal gestation only or gestation and lactation. Studies in this review identify a real risk of type 2 diabetes and obesity in male offspring exposed to a maternal HFD. Poor glycaemic control in the offspring appears to be independent of maternal obesity, birth weight or post-weaning macronutrient intake. Inconsistencies between studies however, limit our capacity to identify mechanisms for the developmental origin of these diseases in animal models of overnutrition.H Ainge, C Thompson, SE Ozanne and KB Roone

Determinants of serum organochlorine pesticide and polychlorinated biphenyl levels in middle-aged Korean adults

The serum levels of organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) were measured in a middle-aged Korean population and investigated associations with age, gender, body mass index (BMI), metabolic syndrome (MS), type 2 diabetes mellitus (T2DM), and dietary habits. The median concentrations of 22 OCPs and 34 PCBs in the serum samples were 483 and 216 ng g(-1) lipid, respectively. The most abundant compound was p,p'-DDE, followed by PCB 153, beta-HCH, PCB 118, and PCB 180. The results of multiple linear regression and other statistical analyses revealed that serum OCP and PCB levels were higher in women and were positively correlated with age. BMI was positively associated with serum OCP and PCB levels, reflecting the influence of food intake and the preserving effect of body fat. MS and T2DM were significantly associated with serum OCP and PCB levels. The intake of animal foods had positive associations with serum OCP and PCB levels, whereas the intake of phytogenic foods showed negative associations, presumably because of contamination levels in food items and food matrices that governs absorption and excretion of OCPs and PCBs in the body. The relationship between dietary habits and serum OCP and PCB levels were different in participants with MS compared to healthy participants, suggesting MS may alter the influence of food intake on serum OCP and PCB levels