Complete genome sequence of Torque teno indri virus 1, a novel anellovirus in blood from a free-living lemur

ABSTRACT We identified Torque teno indri virus 1 (TTIV1), the first anellovirus in a free-living lemur ( Indri indri ). The complete circular 2,572-nucleotide (nt) TTIV1 genome is distantly related to torque teno sus virus. Phylogenetic and sequence analyses support TTIV1 as a putative member of a new genus within the Anelloviridae family. </jats:p

Structure and Response in the World Trade Network

We examine how the structure of the world trade network has been shaped by globalization and recessions over the last 40 years. We show that by treating the world trade network as an evolving system, theory predicts the trade network is more sensitive to evolutionary shocks and recovers more slowly from them now than it did 40 years ago, due to structural changes in the world trade network induced by globalization. We also show that recession-induced change to the world trade network leads to an \emph{increased} hierarchical structure of the global trade network for a few years after the recession.Comment: 4 pages, 4 figures, to appear in Phys. Rev. Let

Renormalization of Drift and Diffusivity in Random Gradient Flows

We investigate the relationship between the effective diffusivity and effective drift of a particle moving in a random medium. The velocity of the particle combines a white noise diffusion process with a local drift term that depends linearly on the gradient of a gaussian random field with homogeneous statistics. The theoretical analysis is confirmed by numerical simulation. For the purely isotropic case the simulation, which measures the effective drift directly in a constant gradient background field, confirms the result previously obtained theoretically, that the effective diffusivity and effective drift are renormalized by the same factor from their local values. For this isotropic case we provide an intuitive explanation, based on a {\it spatial} average of local drift, for the renormalization of the effective drift parameter relative to its local value. We also investigate situations in which the isotropy is broken by the tensorial relationship of the local drift to the gradient of the random field. We find that the numerical simulation confirms a relatively simple renormalization group calculation for the effective diffusivity and drift tensors.Comment: Latex 16 pages, 5 figures ep

Disclination Asymmetry in Two-Dimensional Nematic Liquid Crystals with Unequal Frank Constants

The behavior of a thin film of nematic liquid crystal with unequal Frank constants is discussed. Distinct Frank constants are found to imply unequal core energies for $+1/2$ and $-1/2$ disclinations. Even so, a topological constraint is shown to ensure that the bulk densities of the two types of disclinations are the same. For a system with free boundary conditions, such as a liquid membrane, unequal core energies simply renormalize the Gaussian rigidity and line tension.Comment: RevTex forma

Species-specific transmission of novel picornaviruses in lemurs

The roles of host genetics versus exposure and contact frequency in driving cross-species transmission remain the subject of debate. Here, we used a multitaxon lemur collection at the Saint Louis Zoo in the United States as a model to gain insight into viral transmission in a setting of high interspecies contact. Lemurs are a diverse and understudied group of primates that are highly endangered. The speciation of lemurs, which are endemic to the island of Madagascar, occurred in geographic isolation apart from that of continental African primates. Although evidence of endogenized viruses in lemur genomes exists, no exogenous viruses of lemurs have been described to date. Here we identified two novel picornaviruses in fecal specimens of ring-tailed lemurs (Lemur catta) and black-and-white ruffed lemurs (Varecia variegata). We found that the viruses were transmitted in a species-specific manner (lesavirus 1 was detected only in ring-tailed lemurs, while lesavirus 2 was detected only in black-and-white ruffed lemurs). Longitudinal sampling over a 1-year interval demonstrated ongoing infection in the collection. This was supported by evidence of viral clearance in some animals and new infections in previously uninfected animals, including a set of newly born triplets that acquired the infection. While the two virus strains were found to be cocirculating in a mixed-species exhibit of ring-tailed lemurs, black-and-white ruffed lemurs, and black lemurs, there was no evidence of cross-species transmission. This suggests that despite high-intensity contact, host species barriers can prevent cross-species transmissions of these viruses. IMPORTANCE Up to 75% of emerging infectious diseases in humans today are the result of zoonotic transmission. However, a challenge in understanding transmission dynamics has been the limited models of cross-species transmission. Zoos provide a unique opportunity to explore parameters defining viral transmission. We demonstrated that ongoing virus transmission in a mixed lemur species exhibit was species specific. This suggests that despite high contact intensity, host species barriers contribute to protection from cross-species transmission of these viruses. While the combinations of species might differ, most zoological parks worldwide commonly feature mixed-species exhibits. Collectively, this report demonstrates a widely applicable approach toward understanding infectious disease transmission

Whole of degree curriculum design: Transitioning students in, through and out of higher education

Panel Discussio

Reactive Turbulent Flow in Low-Dimensional, Disordered Media

We analyze the reactions $A+A \to \emptyset$ and $A + B \to \emptyset$ occurring in a model of turbulent flow in two dimensions. We find the reactant concentrations at long times, using a field-theoretic renormalization group analysis. We find a variety of interesting behavior, including, in the presence of potential disorder, decay rates faster than that for well-mixed reactions.Comment: 6 pages, 4 figures. To appear in Phys. Rev.