11,737 research outputs found
Higher Loop Spin Field Correlators in D=4 Superstring Theory
We develop calculational tools to determine higher loop superstring
correlators involving massless fermionic and spin fields in four space time
dimensions. These correlation functions are basic ingredients for the
calculation of loop amplitudes involving both bosons and fermions in D=4
heterotic and superstring theories. To obtain the full amplitudes in Lorentz
covariant form the loop correlators of fermionic and spin fields have to be
expressed in terms of SO(1,3) tensors. This is one of the main achievements in
this work.Comment: 59 pages, 1 figure; v2: final version published in JHE
Optimistic distributionally robust optimization for nonparametric likelihood approximation
The likelihood function is a fundamental component in Bayesian statistics. However, evaluating the likelihood of an observation is computationally intractable in many applications. In this paper, we propose a non-parametric approximation of the likelihood that identifies a probability measure which lies in the neighborhood of the nominal measure and that maximizes the probability of observing the given sample point. We show that when the neighborhood is constructed by the Kullback-Leibler divergence, by moment conditions or by the Wasserstein distance, then our optimistic likelihood can be determined through the solution of a convex optimization problem, and it admits an analytical expression in particular cases. We also show that the posterior inference problem with our optimistic likelihood approximation enjoys strong theoretical performance guarantees, and it performs competitively in a probabilistic classification task
Restrictions and extensions of semibounded operators
We study restriction and extension theory for semibounded Hermitian operators
in the Hardy space of analytic functions on the disk D. Starting with the
operator zd/dz, we show that, for every choice of a closed subset F in T=bd(D)
of measure zero, there is a densely defined Hermitian restriction of zd/dz
corresponding to boundary functions vanishing on F. For every such restriction
operator, we classify all its selfadjoint extension, and for each we present a
complete spectral picture.
We prove that different sets F with the same cardinality can lead to quite
different boundary-value problems, inequivalent selfadjoint extension
operators, and quite different spectral configurations. As a tool in our
analysis, we prove that the von Neumann deficiency spaces, for a fixed set F,
have a natural presentation as reproducing kernel Hilbert spaces, with a
Hurwitz zeta-function, restricted to FxF, as reproducing kernel.Comment: 63 pages, 11 figure
A national survey of services for the prevention and management of falls in the UK
Background: The National Health Service (NHS) was tasked in 2001 with developing service provision to prevent falls in older people. We carried out a national survey to provide a description of health and social care funded UK fallers services, and to benchmark progress against current
practice guidelines.
Methods: Cascade approach to sampling, followed by telephone survey with senior member of the fall service. Characteristics of the service were assessed using an internationally agreed taxonomy. Reported service provision was compared against benchmarks set by the National
Institute for Health and Clinical Excellence (NICE).
Results: We identified 303 clinics across the UK. 231 (76%) were willing to participate. The majority of services were based in acute or community hospitals, with only a few in primary care or emergency departments. Access to services was, in the majority of cases, by health professional
referral. Most services undertook a multi-factorial assessment. The content and quality of these assessments varied substantially. Services varied extensively in the way that interventions were delivered, and particular concern is raised about interventions for vision, home hazard modification, medication review and bone health.
Conclusion: The most common type of service provision was a multi-factorial assessment and intervention. There were a wide range of service models, but for a substantial number of services, delivery appears to fall below recommended NICE guidance
Delivering reform in English healthcare: an ideational perspective
A variety of perspectives has been put forward to understand reform across healthcare systems. Recently, some have called for these perspectives to give greater recognition to the role of ideational processes. The purpose of this article is to present an ideational approach to understanding the delivery of healthcare reform. It draws on a case of English healthcare reform â the Next Stage Review led by Lord Darzi â to show how the delivery of its reform proposals was associated with four ideational frames. These frames built on the idea of âprogressâ in responding to existing problems; the idea of âprevailing policyâ in forming part of a bricolage of ideas within institutional contexts; the idea of âprescriptionâ as top-down structural change at odds with local contexts; and the idea of âprofessional disputesâ in challenging the notion of clinical engagement across professional groups. The article discusses the implications of these ideas in furthering our understanding of policy change, conflict and continuity across healthcare settings
A fourth generation, anomalous like-sign dimuon charge asymmetry and the LHC
A fourth chiral generation, with in the range GeV and a moderate value of the CP-violating phase can explain the
anomalous like-sign dimuon charge asymmetry observed recently by the D0
collaboration. The required parameters are found to be consistent with
constraints from other and decays. The presence of such quarks, apart
from being detectable in the early stages of the LHC, would also have important
consequences in the electroweak symmetry breaking sector.Comment: 18 pages, 9 figures, Figure 1 is modified, more discussions are added
in section 2. new references adde
Curves on Heisenberg invariant quartic surfaces in projective 3-space
This paper is about the family of smooth quartic surfaces that are invariant under the Heisenberg group . For a
very general such surface , we show that the Picard number of is 16 and
determine its Picard group. It turns out that the general Heisenberg invariant
quartic contains 320 smooth conics and that in the very general case, this
collection of conics generates the Picard group.Comment: Updated references, corrected typo
Combination of electroweak and QCD corrections to single W production at the Fermilab Tevatron and the CERN LHC
Precision studies of the production of a high-transverse momentum lepton in
association with missing energy at hadron colliders require that electroweak
and QCD higher-order contributions are simultaneously taken into account in
theoretical predictions and data analysis. Here we present a detailed
phenomenological study of the impact of electroweak and strong contributions,
as well as of their combination, to all the observables relevant for the
various facets of the p\smartpap \to {\rm lepton} + X physics programme at
hadron colliders, including luminosity monitoring and Parton Distribution
Functions constraint, precision physics and search for new physics signals.
We provide a theoretical recipe to carefully combine electroweak and strong
corrections, that are mandatory in view of the challenging experimental
accuracy already reached at the Fermilab Tevatron and aimed at the CERN LHC,
and discuss the uncertainty inherent the combination. We conclude that the
theoretical accuracy of our calculation can be conservatively estimated to be
about 2% for standard event selections at the Tevatron and the LHC, and about
5% in the very high transverse mass/lepton transverse momentum tails. We
also provide arguments for a more aggressive error estimate (about 1% and 3%,
respectively) and conclude that in order to attain a one per cent accuracy: 1)
exact mixed corrections should be computed in
addition to the already available NNLO QCD contributions and two-loop
electroweak Sudakov logarithms; 2) QCD and electroweak corrections should be
coherently included into a single event generator.Comment: One reference added. Final version to appear in JHE
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A phase II study of temozolomide vs. procarbazine in patients with glioblastoma multiforme at first relapse.
A randomized, multicentre, open-label, phase II study compared temozolomide (TMZ), an oral second-generation alkylating agent, and procarbazine (PCB) in 225 patients with glioblastoma multiforme at first relapse. Primary objectives were to determine progression-free survival (PFS) at 6 months and safety for TMZ and PCB in adult patients who failed conventional treatment. Secondary objectives were to assess overall survival and health-related quality of life (HRQL). TMZ was given orally at 200 mg/m(2)/day or 150 mg/m(2)/day (prior chemotherapy) for 5 days, repeated every 28 days. PCB was given orally at 150 mg/m(2)/day or 125 mg/m(2)/day (prior chemotherapy) for 28 days, repeated every 56 days. HRQL was assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30 [+3]) and the Brain Cancer Module 20 (BCM20). The 6-month PFS rate for patients who received TMZ was 21%, which met the protocol objective. The 6-month PFS rate for those who received PCB was 8% (P = 0.008, for the comparison). Overall PFS significantly improved with TMZ, with a median PFS of 12.4 weeks in the TMZ group and 8.32 weeks in the PCB group (P = 0.0063). The 6-month overall survival rate for TMZ patients was 60% vs. 44% for PCB patients (P = 0.019). Freedom from disease progression was associated with maintenance of HRQL, regardless of treatment received. TMZ had an acceptable safety profile; most adverse events were mild or moderate in severity
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